Adjunctive pharmacotherapy and treatment patterns among initiators of SSRI therapy for major depressive disorder: A cohort study using a primary care database

Classi, Peter; Ball, Susan; Davé, Shreya; Maguire, Andrew; Le, Trong Kim

doi:10.4236/ojpsych.2012.23028

OJPsych

2012

DOI: 10.4236/ojpsych.2012.23028

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Adjunctive pharmacotherapy and treatment patterns among initiators of SSRI therapy for major depressive disorder: A cohort study using a primary care database

Peter Classi¹,

Susan Ball²,

Shreya Davé³

et al.

Abstract: Objective: Adjunctive therapy is often used for treatment of major depressive disorder (MDD) following an inadequate response to an antidepressant. However, there is little information regarding its practice within primary care in the United Kingdom (UK).

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The use of adjunctive antipsychotics to treat depression in UK primary care

Lamy¹,

Saragoussi²,

Johnson

et al. 2017

Current Medical Research and Opinion

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Antipsychotics were rarely used to treat depression between 2005-2013 in UK primary care. The choice of adjunctive antipsychotic therapy changed over this time, with atypical antipsychotics now representing the preferred treatment choice. However, information on patients strictly cared for in other settings, such as by psychiatrists or in hospitals, potentially more severe patients, was unavailable and may differ. Nonetheless, the high off-label use in primary care, even after the authorization of quetiapine, suggests that there is a need for more licensed treatment options for adjunctive antipsychotic therapy in major depressive disorder.

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The use of adjunctive antipsychotics to treat depression in UK primary care

Lamy¹,

Saragoussi²,

Johnson

et al. 2017

Current Medical Research and Opinion

View full text Add to dashboard Cite

show abstract

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Adjunctive pharmacotherapy and treatment patterns among initiators of SSRI therapy for major depressive disorder: A cohort study using a primary care database

Abstract: Objective: Adjunctive therapy is often used for treatment of major depressive disorder (MDD) following an inadequate response to an antidepressant. However, there is little information regarding its practice within primary care in the United Kingdom (UK).

Cited by 1 publication

References 27 publications

The use of adjunctive antipsychotics to treat depression in UK primary care

The use of adjunctive antipsychotics to treat depression in UK primary care

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