Adjunctive local antibiotic therapy in the treatment of peri‐implantitis II: clinical and radiographic outcomes

Salvi, Giovanni E.; Persson, G. Rutger; Heitz‐Mayfield, Lisa; Frei, Marc; Lang, Niklaus P.

doi:10.1111/j.1600-0501.2007.01377.x

Cited by 108 publications

(123 citation statements)

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“…Available instruments are not proper for implant decontamination and cannot reach infected surfaces and tissues. 36 Implant surface microstructures, designed to enhance osseointegration, protect the bacteria. 37 Furthermore, high affinity of Staphylococcus aureus to titanium surfaces is reported in related studies.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Antimicrobial Photodynamic Therapy as an Adjunctive to Mechanical Debridement in the Treatment of Peri-implant Diseases: A Randomized Controlled Clinical Trial

Karimi¹,

Hasani²,

Khosroshahian

2016

J Lasers Med Sci

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Introduction:The purpose of the present study was to assess the clinical effects of antimicrobial photodynamic therapy (PDT) after closed surface scaling in the treatment of peri-implant diseases. Methods: Ten patients with a total of 15 pairs of dental implants, showing clinical and radiographic signs of peri-implant diseases, were included in this study. In each patient, one implant randomly served as control implant and the other served as test implant. The control implants were treated with closed surface scaling only and the test implants received additionally PDT, using light with a wavelength of 630 nm and intensity of 2000 mw/cm 2 for 120 seconds after application of photosensitizer in peri-implant sulcus. Clinical parameters were evaluated before and 1.5 and 3 months after treatment. Results: Statistical analysis showed significant differences in probing pocket depth (PPD), clinical attachment loss (CAL), bleeding on probing (BOP), and gingival index (GI) at each time point between the two groups. There were no statistically significant changes with respect to any of the parameters in the control group. Complete resolution of BOP at 3 months was achieved in 100% of test implants. At 1.5 and 3 months, there were significant differences in the mean probing depth and CAL gain measurements at implants in the test group. Conclusion: The present study revealed that adjunctive use of PDT following closed surface scaling could lead to clinical improvement of peri-implant diseases. Further studies are necessary to confirm our results. Keywords: clinical trial; dental implant; mechanical debridement; peri-implantitis; photodynamic therapy Please cite this article as follows: Karimi MR, Hasani A, Khosroshahian S. Efficacy of antimicrobial photodynamic therapy as an adjunctive to mechanical debridement in the treatment of peri-implant diseases: a randomized controlled clinical trial.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Antimicrobial Photodynamic Therapy as an Adjunctive to Mechanical Debridement in the Treatment of Peri-implant Diseases: A Randomized Controlled Clinical Trial

Karimi¹,

Hasani²,

Khosroshahian

2016

J Lasers Med Sci

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“…Because bacterial contamination of dental implants plays a central role in the development of peri-implantitis [3][4][5], several methods for decontaminating the implant surface have been developed. In particular, use of air-powered abrasive powder, citric acid, mechanical cleaning with metal and plastic curettes, or ultrasonic devices [6][7][8], in combination with local and systemic antibiotic, have been proposed for the treatment of peri-implantitis [9]. However, none of these methods can completely eliminate bacteria from infected implants [10,11].…”

Section: Introductionmentioning

confidence: 99%

Thermal effects of λ = 808 nm GaAlAs diode laser irradiation on different titanium surfaces

Giannelli

Lasagni²,

Bani

2015

Lasers Med Sci

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Diode lasers are widely used in dental laser treatment, but little is known about their thermal effects on different titanium implant surfaces. This is a key issue because already a 10 °C increase over the normal body temperature can induce bone injury and compromise osseo-integration. The present study aimed at evaluating the temperature changes and surface alterations experienced by different titanium surfaces upon irradiation with a λ = 808 nm diode laser with different settings and modalities. Titanium discs with surfaces mimicking different dental implant surfaces including TiUnite and anodized, machined surfaces were laser-irradiated in contact and non-contact mode, and with and without airflow cooling. Settings were 0.5-2.0 W for the continuous wave mode and 10-45 μJ, 20 kHz, 5-20 μs for the pulsed wave mode. The results show that the surface characteristics have a marked influence on temperature changes in response to irradiation. The TiUnite surface, corresponding to the osseous interface of dental implants, was the most susceptible to thermal rise, while the machined surfaces, corresponding to the implant collar, were less affected. In non-contact mode and upon continuous wave emission, the temperature rose above the 50 °C tissue damage threshold. Scanning electron microscopy investigation of surface alterations revealed that laser treatment in contact mode resulted in surface scratches even when no irradiation was performed. These findings indicate that the effects of diode laser irradiation on implant surfaces depend on physical features of the titanium coating and that in order to avoid thermal or physical damage to implant surface the irradiation treatment has to be carefully selected.

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“…Extra-oral antisepsis was performed by rubbing a sterile gauze soaked in 2% chlorhexidine gluconate solution and intra-oral through careful and / or in the initial healing period. Infection is one of the factors responsible for failure of implants in the postoperative period [3][4] . Likewise any other surgical procedure, during the installation of dental implants, contamination of the manipulated sites can occur reinforcing the importance of preventing infection of the surgical site.…”

Section: Conclusãomentioning

confidence: 99%

Evaluation of two amoxicillin protocols for antibiotic prophylaxis in implant placement surgeries

Andrade

Ramacciato

Carvalho

et al. 2017

RGO, Rev. Gaúch. Odontol.

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ObjectiveThe aim of this study was to evaluate the effectiveness of two amoxicillin protocols for antibiotic prophylaxis in implant placement surgeries. (mean 51,9 ± 2,5 Methods A clinical study was performed with 66 volunteers of both genders RESUMOObjetivo Avaliar a eficácia de dois protocolos de amoxicilina em cirurgias para instalação de implantes. MétodosFoi realizado um estudo clinico com 66 voluntários de ambos os gêneros (idade média 51,9±2,5 anos) que atenderam aos critérios de inclusão e que foram distribuídos por sorteio em 2 grupos: Grupo 1 (n=35) -amoxicilina (2g) por via oral 1h antes da cirurgia e Grupo 2 (n=31) -amoxicilina (2g) por via oral 1h antes da cirurgia e 500mg a cada 8 horas durante 7 dias. Os parâmetros avaliados no pós-operatório foram ocorrência de reações adversas, dor e perda de implantes. A dor foi avaliada no dia da cirurgia (antes, imediatamente após e à noite), 24h, 48h, 72h e 1 semana após as cirurgias, e os demais parâmetros foram avaliados em consultas diárias até o terceiro dia pós-cirúrgico, 7 dias e 3 meses após as cirurgias. Os resultados foram submetidos à análise estatística com nível de significância de 5%. ResultadosReações adversas (cefaleia, diarréia, dor estomacal e náusea) e perda de implantes ocorreram apenas em G2 (4 voluntários e 3 implantes, respectivamente), e em relação à dor foram observados valores maiores para G2 nos tempos "à noite (p=0,0043), 24h (p=0,0013), 48h (p=0,0187) e 72h (p=0,0445). ConclusãoOs dados sugerem que a dose única de amoxicilina (2g) foi eficaz na profilaxia antibiótica para cirurgias de implantes, e que a amoxicilina no período pós-operatório não proporcionou benefício adicional.

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Adjunctive local antibiotic therapy in the treatment of peri‐implantitis II: clinical and radiographic outcomes

Abstract: Non-surgical mechanical treatment of peri-implantitis lesions with adjunctive local delivery of microencapsulated minocycline led to positive effects on clinical parameters up to 12 months.

Cited by 108 publications

References 20 publications

Efficacy of Antimicrobial Photodynamic Therapy as an Adjunctive to Mechanical Debridement in the Treatment of Peri-implant Diseases: A Randomized Controlled Clinical Trial

Efficacy of Antimicrobial Photodynamic Therapy as an Adjunctive to Mechanical Debridement in the Treatment of Peri-implant Diseases: A Randomized Controlled Clinical Trial

Thermal effects of λ = 808 nm GaAlAs diode laser irradiation on different titanium surfaces

Evaluation of two amoxicillin protocols for antibiotic prophylaxis in implant placement surgeries

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