Adjunctive Intranasal Oxytocin Reduces Symptoms in Schizophrenia Patients

Feifel, David; MacDonald, Kai; Nguyen, Angel; Cobb, Patrice; Warlan, Heather; Galangue, Barbara; Minassian, Arpi; Becker, Olga; Cooper, Jason D.; Perry, William; Lefèbvre, M. C.; Gonzales, James; Hadley, Allison

doi:10.1016/j.biopsych.2010.04.039

Cited by 280 publications

(226 citation statements)

References 16 publications

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“…The current links between OXT and DA and the pronounced effects over tasks in the social domain mean that OXT is of particular interest to clinical groups. 125 Preliminary studies have shown its potential efficacy in patients with schizophrenia [126][127][128] and autism 129 and have shown behavioural effects in patients with schizophrenia, 130,131 depression, 32 generalized anxiety disorder 28,29 and autism. 132 Importantly, the prosocial effects of OXT may offer potential for synergistic pharmacotherapeutic and psychotherapeutic treatments of these severe disorders.…”

Section: Resultsmentioning

confidence: 99%

Neurophysiological effects of acute oxytocin administration: systematic review and meta-analysis of placebo-controlled imaging studies

Wigton

Raduà

Allen

et al. 2015

jpn

164

119

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Section: Resultsmentioning

confidence: 99%

Neurophysiological effects of acute oxytocin administration: systematic review and meta-analysis of placebo-controlled imaging studies

Wigton

Raduà

Allen

et al. 2015

jpn

164

119

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“…As oxytocin and vasopressin systems contribute to different aspects of brain physiology in different species thus having a role in speciestypical social behaviors (Goodson, 2013), it is important to sample from a wide variety of animal systems to get a broad picture of both the potential and limitations of these systems in humans. The ability to translate appropriately across species and developmental time points becomes imperative as the enthusiasm grows for intranasal oxytocin and vasopressin therapies in various developmental disabilities and mental illness (Guastella et al, 2009(Guastella et al, , 2010Andari et al, 2010;Feifel et al, 2010;Goldman et al, 2011;Pedersen et al, 2011;Simeon et al, 2011;Hall et al, 2012). In addition to gathering data from a wide variety of species, it will be important to understand the behavioral context in which oxytocin and vasopressin function.…”

Section: Discussionmentioning

confidence: 99%

Developmental Perspectives on Oxytocin and Vasopressin

Hammock

2014

Neuropsychopharmacol

149

144

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The related neuropeptides oxytocin and vasopressin are involved in species-typical behavior, including social recognition behavior, maternal behavior, social bonding, communication, and aggression. A wealth of evidence from animal models demonstrates significant modulation of adult social behavior by both of these neuropeptides and their receptors. Over the last decade, there has been a flood of studies in humans also implicating a role for these neuropeptides in human social behavior. Despite popular assumptions that oxytocin is a molecule of social bonding in the infant brain, less mechanistic research emphasis has been placed on the potential role of these neuropeptides in the developmental emergence of the neural substrates of behavior. This review summarizes what is known and assumed about the developmental influence of these neuropeptides and outlines the important unanswered questions and testable hypotheses. There is tremendous translational need to understand the functions of these neuropeptides in mammalian experience-dependent development of the social brain. The activity of oxytocin and vasopressin during development should inform our understanding of individual, sex, and species differences in social behavior later in life.

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“…Interestingly, the AVPR1a receptor of the closely related nonapeptide vasopressin has also been associated with ASD [40][41][42]. This provisional role of OT in ASD, is further supported by two linkage studies [43,44], clinical evidence by several groups demonstrating clinical improvement in ASD following OT administration [45][46][47][48][49][50][51] (also see [52,53]) and studies showing that ASD is also associated with alterations in OT plasma levels [54].…”

Section: Oxytocin and Autism Spectrum Disorders (Asd)mentioning

confidence: 91%

Are retinoids potential therapeutic agents in disorders of social cognition including autism?

et al. 2011

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Edited by Sergio Papa, Gianfranco Gilardi and Wilhelm JustKeywords: Autism spectrum disorder (ASD) All-trans retinoic acid (ATRA) CD38 Oxytocin Polymorphism a b s t r a c t Increasing evidence suggests that the nonapeptide, oxytocin (OT), helps shape social and affiliative behaviors not only in lower mammals but also in humans. Recently, an essential mediator of brain OT release has been discovered, ADP-ribosyl cyclase and/or CD38. We have subsequently shown that polymorphisms across the CD38 gene are associated with autism spectrum disorders (ASD). Notably, CD38 expression in lymphoblastoid cells (LBC) is reduced in cell lines derived from ASD subjects compared to parental cell lines. Intriguingly, a correlation was observed between CD38 expression and measures of social function in ASD. Finally, we have shown that all-trans retinoic acid (ATRA), a known inducer of CD38 transcription, can rescue low CD38 expressing LBC lines derived from ASD subjects and restore normal levels of transcription of this ectoenzyme providing 'proof of principle' in a peripheral model that retinoids are potential therapeutic agents in ASD. Ó 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. OxytocinClassically, the nonapeptide oxytocin (OT) has been viewed as a hypothalamic neuropeptide that is released into the general circulation from the neural lobe of the pituitary, inducing uterine contractions during parturition and milk ejection during lactation. OT is derived from a pre-prohormone precursor that is synthesized in the hypothalamus and stored in vesicles at the posterior pituitary for storage and subsequent release into the bloodstream (see [1] for comprehensive review of the oxytocin receptor system). OT and social behaviorBeyond the long-known peripheral effects of OT, a wealth of animal studies have elaborated the role of OT, or their analogues such as isotocin and vasotocin [2], in molding social behavior from fish to mammals [3]. In the past few years the role of OT has also been examined in our own species, and similar to what has been learned from animal studies, it appears that this nonapeptides also influence social behaviors in humans [4,5]. Indeed, OT has been suggested as the 'great facilitator of life' in a recent review [6].In humans, intranasal administration of OT has been shown to increase trust [7], facilitate mind-reading [8], enhance human memory for social identity [9], increase positive communication between couples [10], increase gaze to the eye region [11] and increase generosity [12]. Intriguingly, OT plasma levels have been linked to individual patterns of maternal-fetal attachment [13] and salivary OT levels were associated with bonding to own parents and inversely related to psychological distress, particularly depressive symptoms [14]. Social anxiety symptom severity, adjusted for age and gender in a healthy group of subjects, was associated with higher plasma oxytocin levels [15]. Imaging studies reinforce the role of OT in influencing human social ...

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Adjunctive Intranasal Oxytocin Reduces Symptoms in Schizophrenia Patients

Cited by 280 publications

References 16 publications

Neurophysiological effects of acute oxytocin administration: systematic review and meta-analysis of placebo-controlled imaging studies

Neurophysiological effects of acute oxytocin administration: systematic review and meta-analysis of placebo-controlled imaging studies

Developmental Perspectives on Oxytocin and Vasopressin

Are retinoids potential therapeutic agents in disorders of social cognition including autism?

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