Adjunctive herbal medicine with carbamazepine for bipolar disorders: A double-blind, randomized, placebo-controlled study

Zhang, Zhang-Jin; Kang, Wan-Hu; Tan, Qingrong; Lu, Qiang; Gao, Chengge; Zhang, Feng-Gang; Wang, Huaihai; Ma, Xiancang; Chen, Ce; Wang, Wei; Guo, Li; Zhang, Yahong; Yang, Xiao; Yang, Guangde

doi:10.1016/j.jpsychires.2005.06.002

Cited by 78 publications

(44 citation statements)

References 24 publications

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“…Three large clinical trials using modern methodology have been published since 2000, all of that have confirmed the efficacy of carbamazepine (Weisler et al, 2004, 2005; Zhang et al, 2007). …”

Section: Efficacy Datamentioning

confidence: 99%

“…Adding the herbal agent Free and Easy Wanderer Plus (FEWP) on carbamazepine was not better than carbamazepine alone, but it was in comparison with placebo while carbamazepine monotherapy was not. Technically it does not support the use of FEWP in acute mania, but a number of other interpretations also exist, for example that adding FEWP compensates for the drop in carbamazepine levels (Zhang et al, 2007). However, that study did not define an a-priori primary outcome and therefore its quality is low.…”

Section: Efficacy Datamentioning

confidence: 99%

“…A more recent 12-week double-blind, randomized, placebo-controlled study from China had equivocal results (Zhang et al, 2007). …”

Section: Efficacy Datamentioning

confidence: 99%

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The International College of Neuro-Psychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 2: Review, Grading of the Evidence, and a Precise Algorithm

Fountoulakis

Yatham

Grunze

et al. 2016

IJNPPY

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Background:The current paper includes a systematic search of the literature, a detailed presentation of the results, and a grading of treatment options in terms of efficacy and tolerability/safety.Material and Methods:The PRISMA method was used in the literature search with the combination of the words ‘bipolar,’ ‘manic,’ ‘mania,’ ‘manic depression,’ and ‘manic depressive’ with ‘randomized,’ and ‘algorithms’ with ‘mania,’ ‘manic,’ ‘bipolar,’ ‘manic-depressive,’ or ‘manic depression.’ Relevant web pages and review articles were also reviewed.Results:The current report is based on the analysis of 57 guideline papers and 531 published papers related to RCTs, reviews, posthoc, or meta-analysis papers to March 25, 2016. The specific treatment options for acute mania, mixed episodes, acute bipolar depression, maintenance phase, psychotic and mixed features, anxiety, and rapid cycling were evaluated with regards to efficacy. Existing treatment guidelines were also reviewed. Finally, Tables reflecting efficacy and recommendation levels were created that led to the development of a precise algorithm that still has to prove its feasibility in everyday clinical practice.Conclusions:A systematic literature search was conducted on the pharmacological treatment of bipolar disorder to identify all relevant random controlled trials pertaining to all aspects of bipolar disorder and graded the data according to a predetermined method to develop a precise treatment algorithm for management of various phases of bipolar disorder. It is important to note that the some of the recommendations in the treatment algorithm were based on the secondary outcome data from posthoc analyses.

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Section: Efficacy Datamentioning

confidence: 99%

Section: Efficacy Datamentioning

confidence: 99%

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The International College of Neuro-Psychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 2: Review, Grading of the Evidence, and a Precise Algorithm

Fountoulakis

Yatham

Grunze

et al. 2016

IJNPPY

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“…It also is possible that an additional mood stabilizer, such as lithium, carbamazepine, lamotrigine, or valproate, may have greater utility in those at high risk for switching into mania in light of the recent evidence of acute antidepressant efficacy of valproate [28] and carbamazepine [29], as well as the US Food and Drug Administration (FDA) approval of lamotrigine for the prevention of bipolar depressive recurrences.…”

Section: Aripiprazole In Bipolar Depressionmentioning

confidence: 99%

New findings from the bipolar collaborative network: Clinical implications for therapeutics

Post

Altshuler²,

Frye³

et al. 2006

Curr Psychiatry Rep

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In this article, we highlight recent Bipolar Collaborative Network data. We found that childhood-onset bipolar illness is common, often goes untreated for more than a decade, and carries a poor prognosis. During randomized studies of adjunctive medications in depression: 1) Venlafaxine showed higher switch rates than bupropion or sertraline; 2) Tranylcypromine was as well tolerated as lamotrigine; and 3) Modafinil was more effective than placebo. Finally, in treatment of overweight and obesity, topiramate and sibutramine showed equal efficacy but poor tolerability, and zonisamide data showed that it may be useful for mood and weight loss.

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“…The shelf life of DHYZ is 1 year. The placebo and DHYZ were prepared by Jinan Pharmaceutical (Jinan, Shandong, China) as described by Zhang et al 20 The water extract of the crude herbal materials was processed as described in the Pharmacopoeia of the People's Republic of China, 2000 edition. 19 The resulting powder was formed into tablets, each tablet containing 3 g of the crude herbal mixture.…”

Section: Preparation Of Dhyz and Placebomentioning

confidence: 99%

The beneficial effects of the herbal medicine Di-huang-yin-zi (DHYZ) on patients with ischemic stroke: A Randomized, Placebo controlled clinical study

Yu¹,

Zhi²,

Li³

et al. 2015

Complementary Therapies in Medicine

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Adjunctive herbal medicine with carbamazepine for bipolar disorders: A double-blind, randomized, placebo-controlled study

Cited by 78 publications

References 24 publications

The International College of Neuro-Psychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 2: Review, Grading of the Evidence, and a Precise Algorithm

The International College of Neuro-Psychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 2: Review, Grading of the Evidence, and a Precise Algorithm

New findings from the bipolar collaborative network: Clinical implications for therapeutics

The beneficial effects of the herbal medicine Di-huang-yin-zi (DHYZ) on patients with ischemic stroke: A Randomized, Placebo controlled clinical study

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