Adjunctive Effect of Autologous Platelet-Rich Fibrin in the Treatment of Intrabony Defects in Localized Aggressive Periodontitis Patients: A Randomized Controlled Split-Mouth Clinical Trial

Thorat, Manojkumar; Baghele, Om Nemichand; Rakhewar, P.S.

doi:10.11607/prd.2972

Cited by 24 publications

(33 citation statements)

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“…A PRISMA flow diagram that depicts this selection process is displayed in Figure 1 Table 1. All the 18 studies were RCTs, of which 9 [13,[21][22][23][24][25][26][27][28] were split-mouth design and 9 [29][30][31][32][33][34][35][36][37] were parallel arm design. All the subjects were systematically healthy adults who suffered periodontitis with intrabony defects, except for one study [37] in which participants had periodontal-endodontic lesions with intrabony defects.…”

Section: Study Selection a Total Of 391 Related Articles (78 Inmentioning

confidence: 99%

[Retracted] Use of Platelet‐Rich Fibrin in the Treatment of Periodontal Intrabony Defects: A Systematic Review and Meta‐Analysis

Chen

Ding

Cheng

et al. 2021

BioMed Research International

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Background. Platelet-rich fibrin (PRF) is a kind of autologous platelet concentrate which is easy to obtain and cheap. In recent years, it has been studied to improve the effect of periodontal regeneration. However, few studies have systematically evaluated the complementary effect of PRF in the treatment of intrabony defects. The present review is aimed at systematically assessing the effects of PRF on clinical and radiological outcomes of the surgical treatment of periodontal intrabony defects. Methods. The protocol was registered at PROSPERO (International Prospective Register of Systematic Reviews) as CRD42020206056. An electronic search was conducted in MEDLINE, Cochrane, and EMBASE databases. Only randomized clinical trials were selected. Systematically healthy patients with two or three walls of intrabony defects were considered. Intrabony defect (IBD) depth reduction and bone fill (BF) % were set as primary outcomes while probing depth (PD) reduction, clinical attachment level (CAL) gain, and gingival margin level (GML) gain were considered as the secondary outcome. When possible, a meta-analysis was performed. Results. Eighteen articles fulfilled the inclusion criteria, and seventeen studies were quantitatively analyzed. Of 17 studies, four were rated as high risk of bias and thirteen as the moderate risk of bias. Two comparisons were set: (1) open flap debridement (OFD) combined with PRF and OFD alone and (2) bone grafting (BG) combined with PRF and BG alone. Compared to OFD alone, OFD+PRF showed significantly greater in all primary and secondary outcomes. Compared to BG alone, BG+PRF showed significantly greater in IBD depth reduction, PD reduction, CAL gain, and GML gain. Conclusions. The use of PRF was significantly effective in the treatment of periodontal intrabony defects. The benefit of OFD+PRF may be greater than BG+PRF. PRF can promote early wound healing in periodontal surgery. As all included studies were not at low risk of bias, well-designed RCTs having a high methodological quality are needed to clarify the additional effectiveness of PRF in the treatment of intrabony defects in the future.

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Section: Study Selection a Total Of 391 Related Articles (78 Inmentioning

confidence: 99%

[Retracted] Use of Platelet‐Rich Fibrin in the Treatment of Periodontal Intrabony Defects: A Systematic Review and Meta‐Analysis

Chen

Ding

Cheng

et al. 2021

BioMed Research International

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“…Out of 98, 73 articles were further excluded reason being inappropriate control group, use of BGs and other materials etc. Finally a total number of 25 articles[19222324252627282930313233343536373839404142434445] were included for both quantitative and qualitative synthesis and further meta-analysis [Figure 1].…”

Section: Resultsmentioning

confidence: 99%

“…Articles available in electronic form before their publication in printed form were also considered eligible for inclusion in this meta-analysis. One randomized control trial (RCT)[19] was also considered for inclusion which is already accepted for publication in International Journal of Periodontics and Restorative Dentistry (IJPRD), also can be referred at Clinical Trials Registry India No. REF/12/006069.…”

Section: Methodsmentioning

confidence: 99%

Actual quantitative attachment gain secondary to use of autologous platelet concentrates in the treatment of intrabony defects: A meta-analysis

Baghele

Kathole

Tuteja

et al. 2019

J Indian Soc Periodontol

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Background: There are no authoritative meta-analyses and no clear quantitative assessments available estimating effects of open flap debridement (OFD) combined with platelet-rich fibrin (PRF) or platelet-rich plasma (PRP) over and above that of OFD. This study evaluated the actual quantitative mean gain for various clinical (clinical attachment level [CAL], probing pocket depth [PPD] and gingival marginal level [GML]) and radiographic (intrabony defect depth [IBD]) parameters of Platelet Concentrates- PCs (PRP/PRF) as sole grafting material along with OFD and OFD alone in the treatment of intrabony defects. Materials and Methods: A detailed electronic search was carried out in PUBMED/MEDLINE, COCHRANE, EBSCOHOST, and Google Scholar databases by unifying related search terms with additional hand searches in select specialty journals up to May 2017. The eligibility criteria included human randomized clinical trials, either of a parallel group or a split-mouth design with follow-up period of at least 6 months. Periodontal intrabony defects with radiographic IBD ≥3 mm with corresponding CAL ≥5 mm were included. For the meta-analysis, the inverse variance method was used in fixed- or random-effect models. Results: Actual quantitative mean gains were calculated for OFD with PRF/PRP (CAL = 1.1 mm, IBD = 1.68 mm, PPD = 0.97 mm and GML = 0.48 mm) over and above that of OFD alone. Conclusion: Because of very high heterogeneity, the results may not be dependable. Apart from gains in radiographic bone fill, all other periodontal clinical parameters showed negligible gains. Using PRF technologies in periodontal intrabony defects may not be of great clinical significance over and above that of OFD alone, the effect sizes are also not large enough.

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“…Third, PRF is easy to prepare and manipulate, and it is inexpensive. [25] Patients receiving dental implants after this sinus floor augmentation surgery with PRF technology showed a 100% survival rate with a mean follow-up of 33 months. [26] In addition, Dohan et al [21] showed that PRF also plays a crucial role in suppressing inflammatory reactions, thus acting as a node of immune regulation; these effects were attributed to the release of anti-inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Platelet-Rich Fibrin as an Adjunctive Material to Bone Graft in Maxillary Sinus Augmentation: A Meta-Analysis of Randomized Controlled Trails

Liu

Yan

Chen

et al. 2019

BioMed Research International

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Purpose. To date, it remains unknown whether the addition of platelet-rich fibrin (PRF) to bone grafts actually improves the effectiveness of maxillary sinus augmentation. This study aimed to perform a meta-analysis to evaluate the efficacy of PRF in sinus lift. Materials and Methods. PubMed, Embase, and the Cochrane Library were searched. Randomized controlled studies were identified. The risk of bias was evaluated using the Cochrane Collaboration tool. Results. Five RCTs were included in our meta-analysis. Clinical, radiographic, and histomorphometric outcomes were considered. No implant failure or graft failure was detected in all included studies within the follow-up period. The percentage of contact length between newly formed bone substitute and bone in the PRF group was lower but lacked statistical significance (3.90%, 95% CI, -2.91% to 10.71%). The percentages of new bone formation (-1.59%, 95% CI, -5.36% to 2.18%) and soft-tissue area (-3.73%, 95% CI, -10.11% to 2.66%) were higher in the PRF group but were not significantly different. The percentage of residual bone graft was not significant in either group (4.57%, 95% CI, 0% to 9.14%). Conclusions. Within the limitations of this review, it was concluded that there were no statistical differences in survival rate, new bone formation, contact between newly formed bone and bone substitute, percentage of residual bone graft (BSV/TV), and soft-tissue area between the non-PRF and PRF groups. Current evidence supporting the necessity of adding PRF to bone graft in sinus augmentation is limited.

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Adjunctive Effect of Autologous Platelet-Rich Fibrin in the Treatment of Intrabony Defects in Localized Aggressive Periodontitis Patients: A Randomized Controlled Split-Mouth Clinical Trial

Cited by 24 publications

References 0 publications

[Retracted] Use of Platelet‐Rich Fibrin in the Treatment of Periodontal Intrabony Defects: A Systematic Review and Meta‐Analysis

[Retracted] Use of Platelet‐Rich Fibrin in the Treatment of Periodontal Intrabony Defects: A Systematic Review and Meta‐Analysis

Actual quantitative attachment gain secondary to use of autologous platelet concentrates in the treatment of intrabony defects: A meta-analysis

Effectiveness of Platelet-Rich Fibrin as an Adjunctive Material to Bone Graft in Maxillary Sinus Augmentation: A Meta-Analysis of Randomized Controlled Trails

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