Adjunctive effect of a polylactide/polyglycolide copolymer in the treatment of deep periodontal intra‐osseous defects: a randomized clinical trial

Abstract

The results indicate that OFD with and without PLA/PGA graft provide clinically and statistically significant improvements in PD and CAL measurements. However, the additional use of PLA/PGA did not provide an additional benefit in terms of CAL gain and PD reduction compared with OFD procedure.

Use of Fisiograft in Intrabony Defects- A Clinical and Radiological Study

“…On comparison, our study results correlate with the Minenna et al, study [14] which showed no significant changes in clinical parameters, CAL gain and PD reduction among the groups at the end of the study period, however gingival margin position showed statistically significant apical shift in controls, whereas Minnena reported no significant differences in recession depth among groups [Table/ Fig-7-9]. The study results are in contrast with studies of Stratul et al, [15] and Bansal et al, [16].…”

“…On radiographic examination the amount of defect fill in controls and tests showed no significant changes at 9 months which is in accordance with Minnena et al, [14] and contrast to Straul et al, [15] and Bansal et al, study [16] [Table/ Fig-10]. …”

“…So far, to the author's knowledge three clinical trials [14][15][16] have been done using various forms of Fisiograft® in intrabony defects showing contradictory results.…”

Preparation and characterization of biodegradable scaffolds of poly(lactide-co-glycolide) 50:50 and hydroxyapatite for dental applications

“…Implantation of PLA has been tried to prevent dry socket with contrasting results. [8] Similarly, PLGA 50:50 has been used as sponge, gel or powder to fill the extraction site. [6] The advantage of using biodegradable devices is that they not only act as scaffold to prevent the bone resorption but can also be used as carriers of drugs or biomolecules.…”

“…[6] The advantage of using biodegradable devices is that they not only act as scaffold to prevent the bone resorption but can also be used as carriers of drugs or biomolecules. [8] They undergo degradation due to the hydrolysis of ester bonds with the resultant formation of acidic monomers. However, several studies have reported biological incompatibility due to their heterogeneous degradation with a sudden release of accumulated acidic degradation products leading to acidic microclimate.…”