Adjunct Methods of the Standard Diabetic Foot Ulceration Therapy

Waniczek, Dariusz; Kozowicz, Andrzej; Muc-Wierzgoń, Małgorzata; Kokot, Teresa; Świętochowska, Elżbieta; Nowakowska-Zajdel, Ewa

doi:10.1155/2013/243568

Cited by 28 publications

(20 citation statements)

References 89 publications

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“…The standard therapy includes management such as debridement of the wound, revascularization procedures, off-loading of the ulcer, antibacterial actions, and supplementation of growth factors and cytokines, leading to stimulation of granulation, epidermization, and angiogenesis [253]. Combining the application of PRP to such wounds and adding hyperbaric oxygen therapy (HBOT) reduce the time required to achieve wound healing, short-term morbidity, and the risk of major amputations [253].…”

Section: Increasing the Influence Of Prpmentioning

confidence: 99%

Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing, and Pain Reduction: Fact or Fiction

Kuffler

2015

Mol Neurobiol

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Platelet-rich plasma (PRP) has been tested in vitro, in animal models, and clinically for its efficacy in enhancing the rate of wound healing, reducing pain associated with injuries, and promoting axon regeneration. Although extensive data indicate that PRP-released factors induce these effects, the claims are often weakened because many studies were not rigorous or controlled, the data were limited, and other studies yielded contrary results. Critical to assessing whether PRP is effective are the large number of variables in these studies, including the method of PRP preparation, which influences the composition of PRP; type of application; type of wounds; target tissues; and diverse animal models and clinical studies. All these variables raise the question of whether one can anticipate consistent influences and raise the possibility that most of the results are correct under the circumstances where PRP was tested. This review examines evidence on the potential influences of PRP and whether PRP-released factors could induce the reported influences and concludes that the preponderance of evidence suggests that PRP has the capacity to induce all the claimed influences, although this position cannot be definitively argued. Well-defined and rigorously controlled studies of the potential influences of PRP are required in which PRP is isolated and applied using consistent techniques, protocols, and models. Finally, it is concluded that, because of the purported benefits of PRP administration and the lack of adverse events, further animal and clinical studies should be performed to explore the potential influences of PRP.

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Section: Increasing the Influence Of Prpmentioning

confidence: 99%

Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing, and Pain Reduction: Fact or Fiction

Kuffler

2015

Mol Neurobiol

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“…By 2030, this number is expected to rise to 552 million (1). Of all diabetic complications, diabetic foot ulcer (DFU) is one of the most devastating and costly syndromes.…”

Section: Introductionmentioning

confidence: 99%

Maggot Debridement Therapy for Diabetic Foot Ulcer: A Case Report

Hajimohammad¹,

Esmaili²,

Rahimi³

2017

Crit Care Nurs J

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Introduction: Diabetic foot problems account for more hospital admissions than any other long term complications of diabetes and are responsible for nearly 50% of all-diabetes-related hospital bed days. Maggot debridement therapy (MDT) offers important advantages for the management of chronic and infected wounds and is used in hundreds of clinics worldwide. This study aimed to evaluate the benefit of maggot debridement therapy (MDT) in the treatment of a patient with a diabetic foot ulcer (DFU). Case Presentation: A 46-year-old male patient with a 6-year-old diabetic foot wound in the right leg. Maggot larvae were placed on the wound. The patient was followed for 6 weeks and luckily had a good response to treatment. Conclusions: This study concluded that MDT is as powerful as traditional debridement in the treatment of diabetic foot ulcers. It would be an achievable different option for diabetic foot ulcer treatment. In conclusion, we observed that MDT could promote wound healing by increasing endothelial proliferation, triggering angiogenesis, and maggot excretion/secretion, which might facilitate this process.

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“…The efficacy of larval debridement therapy against a variety of chronic wounds has been reported in clinical trials and anecdotal observations, particularly in relation to the rate and extent of debridement in comparison with those afforded by standard treatments (Gottrup & Jørgensen, ; Mudge et al ., ), as well as in relation to a reduction in the risk for requirement for major amputation (Sherman, ; Waniczek et al ., ). It is acknowledged that the degradation of non‐viable tissue is enzymatically driven, assisted by antimicrobials for the removal of associated bioburden, and that use of these insect‐derived products leads to the apparent promotion of healing (Sherman, ; Pritchard et al ., ).…”

Section: Introductionmentioning

confidence: 97%

Quality control of a medicinal larval (Lucilia sericata) debridement device based on released gelatinase activity

Pickles

Pritchard

2017

Medical Vet Entomology

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A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription.For more information, please contact eprints@nottingham.ac.uk TitleThe quality control of a medicinal larval (Lucilia sericata) debridement device based on released gelatinase activity. Running HeadRadial-diffusion enzymatic assay for larval activity. AbstractLucilia sericata Meigen (Diptera: Calliphoridae) larvae are manufactured worldwide for the treatment of chronic wounds. Published research has confirmed that the primary clinical effect of the product, debridement (the degradation of non-viable wound tissue), is accomplished by a range of enzymes released by the larvae during feeding. The quality assessment of larval activity is currently achieved during production using meat-based assays, which monitor insect growth and/or the reduction in substrate mass. To support this, we have developed a complementary radial-diffusion enzymatic assay (RDEA) to produce a visual and measureable indication of the activity of larval alimentary products (LAP) collected under standardised conditions, against a gelatin substrate.Using basic laboratory equipment and reagents, the assay is rapid and suited to high-throughput. Assay reproducibility is high (SD 0.06 -0.27, CV 0.75 -4.31%) and the LAP collection procedure does not adversely affect larval survival (mortality < 2%). As a cost-and time-effective method, it is suited to academic or industrial use, supporting good manufacturing (or laboratory) practice (GMP and GLP) as a quality control (QC) assay.

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Adjunct Methods of the Standard Diabetic Foot Ulceration Therapy

Cited by 28 publications

References 89 publications

Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing, and Pain Reduction: Fact or Fiction

Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing, and Pain Reduction: Fact or Fiction

Maggot Debridement Therapy for Diabetic Foot Ulcer: A Case Report

Quality control of a medicinal larval (Lucilia sericata) debridement device based on released gelatinase activity

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