Adiposity during early adulthood, changes in adiposity during adulthood, attained adiposity, and mammographic density among premenopausal women

Alimujiang, Aliya; Appleton, Catherine M.; Colditz, Graham A.; Toriola, Adetunji T.

doi:10.1007/s10549-017-4384-4

Cited by 11 publications

(16 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, two other studies reported that weight gain since age 18 was positively associated with percent breast density in postmenopausal women (17,18).These two studies, did not, however, adjust their analyses for early-life weight, but adjusted for current weight, which likely accounts for the differences in results. We previously observed that adiposity measures at mammogram were correlated with adult weight gain in premenopausal women, thus, including the adiposity measure at mammogram in the regression models could lead to multicollinearity (41). We adjusted for BMI at age 10 instead of BMI at mammogram to take into consideration an individual's initial body size, which likely explains why our findings are consistent with those of Nurses' Health Study, that also adjusted for BMI at age 18 (16).…”

Section: Resultsmentioning

confidence: 59%

Adiposity Change Over the Life Course and Mammographic Breast Density in Postmenopausal Women

Han

Berkey

Herman

et al. 2020

Cancer Prevention Research

Self Cite

View full text Add to dashboard Cite

◥Mammographic breast density is a strong risk factor for breast cancer. We comprehensively investigated the associations of body mass index (BMI) change from ages 10, 18, and 30 to age at mammogram with mammographic breast density in postmenopausal women. We used multivariable linear regression models, adjusted for confounders, to investigate the associations of BMI change with volumetric percent density, dense volume, and nondense volume, assessed using Volpara in 367 women. At the time of mammogram, the mean age was 57.9 years. Compared with women who had a BMI gain of 0.1-5 kg/m 2 from age 10, women who had a BMI gain of 5.1-10 kg/m 2 had a 24.4% decrease [95% confidence interval (CI), 6.0%-39.2%] in volumetric percent density; women who had a BMI gain of 10.1-15 kg/m 2 had a 46.1% decrease (95% CI, 33.0%-56.7%) in volumetric percent density; and women who had a BMI gain of >15 kg/m 2 had a 56.5% decrease (95% CI, 46.0%-65.0%) in volumetric percent density. Similar, but slightly attenuated associations were observed for BMI gain from ages 18 and 30 to age at mammogram and volumetric percent density. BMI gain over the life course was positively associated with nondense volume, but not dense volume. We observed strong associations between BMI change over the life course and mammographic breast density. The inverse associations between early-life adiposity change and volumetric percent density suggest that childhood adiposity may confer long-term protection against postmenopausal breast cancer via its effect of mammographic breast density.

show abstract

Section: Resultsmentioning

confidence: 59%

Adiposity Change Over the Life Course and Mammographic Breast Density in Postmenopausal Women

Han

Berkey

Herman

et al. 2020

Cancer Prevention Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…The between women associations of attained premenopausal BMI and breast density observed in this study were consistent with previous studies. High BMI is associated with high dense volume [33][34][35], but the correlation between BMI and dense area is less strong, and often close to zero [36][37][38][39]. These differences are likely to be a result of volumetric measures representing breast tissue more accurately than area-based methods by accounting for breast thickness and overlapping tissue.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Body Mass Index and Mammographic Density during a Premenopausal Weight Loss Intervention Study

Atakpa

Brentnall

Astley

et al. 2021

Cancers

View full text Add to dashboard Cite

We evaluated the association between short-term change in body mass index (BMI) and breast density during a 1 year weight-loss intervention (Manchester, UK). We included 65 premenopausal women (35–45 years, ≥7 kg adult weight gain, family history of breast cancer). BMI and breast density (semi-automated area-based, automated volume-based) were measured at baseline, 1 year, and 2 years after study entry (1 year post intervention). Cross-sectional (between-women) and short-term change (within-women) associations between BMI and breast density were measured using repeated-measures correlation coefficients and multivariable linear mixed models. BMI was positively correlated with dense volume between-women (r = 0.41, 95%CI: 0.17, 0.61), but less so within-women (r = 0.08, 95%CI: −0.16, 0.28). There was little association with dense area (between-women r = −0.12, 95%CI: −0.38, 0.16; within-women r = 0.01, 95%CI: −0.24, 0.25). BMI and breast fat were positively correlated (volume: between r = 0.77, 95%CI: 0.69, 0.84, within r = 0.58, 95%CI: 0.36, 0.75; area: between r = 0.74, 95%CI: 0.63, 0.82, within r = 0.45, 95%CI: 0.23, 0.63). Multivariable models reported similar associations. Exploratory analysis suggested associations between BMI gain from 20 years and density measures (standard deviation change per +5 kg/m2 BMI: dense area: +0.61 (95%CI: 0.12, 1.09); fat volume: −0.31 (95%CI: −0.62, 0.00)). Short-term BMI change is likely to be positively associated with breast fat, but we found little association with dense tissue, although power was limited by small sample size.

show abstract

“…5,6 It has been hypothesised to be due to greater differentiation of breast tissue during puberty, 2,32 altered oestrogen metabolism, 33 lower adult mammographic density 34,35 and/or lower circulating IGF-I levels 36 in heavier girls. Additional weight gain is associated with a reduction in mammographic density 37 and substantial weight gain leading to obesity suppresses ovarian function, 38,39 with a consequent reduction in endogenous sex hormone, in particular, progesterone, exposure. 38 Weight gain might affect risk through changes in hormone profile because young women with high BMI have been reported to have lower levels of sex-hormonebinding globulin (SHBG), oestradiol and progesterone, and higher levels of free testosterone than women with lower BMI.…”

Section: Discussionmentioning

confidence: 99%

Adult weight change and premenopausal breast cancer risk: A prospective pooled analysis of data from 628,463 women

Schoemaker

Nichols

Wright

et al. 2020

Intl Journal of Cancer

View full text Add to dashboard Cite

Early‐adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It is unclear whether subsequent changes in weight affect risk. We pooled individual‐level data from 17 prospective studies to investigate the association of weight change with premenopausal breast cancer risk, considering strata of initial weight, timing of weight change, other breast cancer risk factors and breast cancer subtype. Hazard ratios (HR) and 95% confidence intervals (CI) were obtained using Cox regression. Among 628,463 women, 10,886 were diagnosed with breast cancer before menopause. Models adjusted for initial weight at ages 18–24 years and other breast cancer risk factors showed that weight gain from ages 18–24 to 35–44 or to 45–54 years was inversely associated with breast cancer overall (e.g., HR per 5 kg to ages 45–54: 0.96, 95% CI: 0.95–0.98) and with oestrogen‐receptor(ER)‐positive breast cancer (HR per 5 kg to ages 45–54: 0.96, 95% CI: 0.94–0.98). Weight gain from ages 25–34 was inversely associated with ER‐positive breast cancer only and weight gain from ages 35–44 was not associated with risk. None of these weight gains were associated with ER‐negative breast cancer. Weight loss was not consistently associated with overall or ER‐specific risk after adjusting for initial weight. Weight increase from early‐adulthood to ages 45–54 years is associated with a reduced premenopausal breast cancer risk independently of early‐adulthood weight. Biological explanations are needed to account for these two separate factors.

show abstract

Adiposity during early adulthood, changes in adiposity during adulthood, attained adiposity, and mammographic density among premenopausal women

Abstract: There is a need for mechanistic studies focusing on early adulthood to provide a better understanding of how adiposity in early life relates to mammographic density, and possibly breast cancer development in premenopausal women.

Cited by 11 publications

References 19 publications

Adiposity Change Over the Life Course and Mammographic Breast Density in Postmenopausal Women

Adiposity Change Over the Life Course and Mammographic Breast Density in Postmenopausal Women

The Relationship between Body Mass Index and Mammographic Density during a Premenopausal Weight Loss Intervention Study

Adult weight change and premenopausal breast cancer risk: A prospective pooled analysis of data from 628,463 women

Contact Info

Product

Resources

About