Adiposity, Chronic Inflammation, and the Prepubertal Decline of Sex Hormone Binding Globulin in Children: Evidence for Associations With the Timing of Puberty (Earlybird 58)

Pinkney, Jonathan; Streeter, Adam; Hosking, Joanne; Mohammod, Mostafir; Jeffery, Alison N.; Wilkin, Terence J.

doi:10.1210/jc.2013-3902

Cited by 51 publications

(67 citation statements)

References 39 publications

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“…Because there is no worldwide unified cutoff for ICPP diagnosis, the cutoff used for ICPP diagnosis in our study was peak LH > 3.3 mIU ml 21 and LH/FSH ratio of over 0.6, combined with clinical manifestations and ultrasound of uterus and ovary according to guidelines for the diagnosis and treatment of precocious puberty (Chinese Ministry of Health, 2010). The basis for using peak LH >3.3 mIU ml 21 in our study is also based on the study by Rosenfield et al (15).…”

Section: Discussionmentioning

confidence: 99%

“…The obese group had a significantly lower LH peak level (median 6.2 mIU ml 21 , interquartile 5.3-11.0) than the overweight group (median 8.5 mIU ml 21 , interquartile 5.3-11.6) (P < 0.05) and the normal-weight group (median 9.1 mIU ml 21 , interquartile 5.2-13.1) (P < 0.001). Although the overweight group had a lower LH peak than the normal-weight group, no statistical significance was found (P 5 0.11).…”

Section: Bmi and Sex Hormonal Parametersmentioning

confidence: 92%

“…The diagnosis of CPP depends upon the combination of clinical manifestations and peak LH response to the GnRH stimulation test. The cutoff level for diagnosis of CPP is peak LH >3.3 mIU ml 21 and LH/FSH ratio >0.6.…”

Section: Diagnosis Clinical and Biochemical Proceduresmentioning

confidence: 99%

“…Blood glucose was determined using a glucose oxidase (hexokinase) method (Roche Diagnostics GmbH, Sandhofer Strasse, Mannheim, Germany; sensitivity 2.0 mg dl 21 ; intraassay CV 1.7%; interassay CV 1.0%). Insulin was determined by chemiluminescence (Abbott Laboratories Diagnostics Division, Abbott Park, IL; sensitivity 1.0 mU ml 21 ; intraassay CV 2.3-4.6%; interassay CV 1.7-4.0%).…”

mentioning

confidence: 99%

“…Insulin was determined by chemiluminescence (Abbott Laboratories Diagnostics Division, Abbott Park, IL; sensitivity 1.0 mU ml 21 ; intraassay CV 2.3-4.6%; interassay CV 1.7-4.0%). Leptin was measured by radioimmunoassay (Beijing North Biotechnology Company, Beijing, China; sensitivities 0.45 ng ml 21 ; intraassay CV <10%; interassay CV <15%). SHBG was measured by electrochemiluminescence (Roche Diagnostics GmbH, Sandhofer Strasse, Mannheim, Germany; sensitivity 0.35 nmol l 21 ; intraassay CV, 2.1-2.7%; interassay CV 2.6-5.6%].The diagnosis of precocious puberty can be excluded if the patient has a history of certain other diseases.…”

mentioning

confidence: 99%

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Impact of BMI on gonadorelin‐stimulated LH peak in premenarcheal girls with idiopathic central precocious puberty

Liang

Zhou

et al. 2015

Obesity

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Objective: To clarify the impact of body mass index (BMI) on luteinizing hormone (LH) secretion in response to gonadorelin (GnRH) stimulation testing in girls diagnosed with idiopathic central precocious puberty (ICPP). Methods: Retrospective single-center cohort study was carried out in 865 confirmed ICPP girls who underwent GnRH stimulation tests. Pubertal development according to Tanner, sex hormone parameters, and LH secretion in response to GnRH-stimulation was compared. Results: Around 609 girls were of normal weight (70.4%), while 168 children (19.4%) were overweight, and 88 (10.2%) were obese. Peak LH levels after GnRH were much higher in the normal-weight group, with a median of 9.1 mIU ml 21 (interquartile 5.2-13.1), compared with the median peak LH in the overweight and obese groups (8.5 mIU ml 21 , interquartile 5.3-11.6, and 6.2 mIU ml 21 , interquartile 5.3-11.0, respectively P < 0.001 for all comparisons). Peak LH/FSH ratio was also lower in the obese group (median 0.6, interquartile 0.68-0.90) compared with the normal-weight (median 0.8, interquartile 0.61-1.11) and overweight (median 0.8, interquartile 0.64-0.92) groups. Conclusions: Higher BMI is associated with lower LH response to GnRH-stimulation testing in girls with ICPP. It is recommended that BMI should be considered when interpreting GnRH-stimulation tests.

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Section: Discussionmentioning

confidence: 99%

Section: Bmi and Sex Hormonal Parametersmentioning

confidence: 92%

Section: Diagnosis Clinical and Biochemical Proceduresmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Impact of BMI on gonadorelin‐stimulated LH peak in premenarcheal girls with idiopathic central precocious puberty

Liang

Zhou

et al. 2015

Obesity

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Causal risk factors for asthma in Mendelian randomization studies: A systematic review and meta‐analysis

Mikkelsen

Landt

Benn

et al. 2022

Clinical & Translational All

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Background Several risk factors for asthma have been proposed; however, the causality of these associations is sometimes unclear. Mendelian randomization is a powerful epidemiological approach that can help elucidate the causality of risk factors. The aim of the present study was to identify causal risk factors for asthma through Mendelian Randomization studies. Methods A systematic search of PubMed and EMBASE was conducted, to identify studies investigating risk factors for asthma or respiratory allergies through Mendelian Randomization. When two or more studies investigated the same risk factor a meta‐analysis was conducted. Of 239 studies initially identified, 41 were included. Results A causal association between adiposity and adult asthma risk was found in 10 out of 12 studies with a summary risk ratio of 1.05 per kg/m2 increase in BMI (95% CI: 1.03–1.07). Puberty timing (n = 3), alcohol (n = 2), and linoleic acid (n = 1) had causal effects on asthma risk, while vitamins/minerals (n = 6) showed no consistent effect on asthma. The effect of smoking on adult asthma conflicted between studies. Several of the significant associations of asthma with immune related proteins (n = 5) and depression (n = 2) investigated through multiple traits analyses could generally benefit from replications in independent datasets. Conclusion This systematic review and meta‐analysis found evidence for causal effects of adiposity, puberty timing, linoleic acid, alcohol, immune related proteins, and depression on risk of asthma.

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Biomarkers of Insulin Resistance

Cox-York

Pereira

2019

Contemporary Endocrinology

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Adiposity, Chronic Inflammation, and the Prepubertal Decline of Sex Hormone Binding Globulin in Children: Evidence for Associations With the Timing of Puberty (Earlybird 58)

Abstract: Adiposity-related endocrine mechanisms and chronic inflammation were associated with the prepubertal decline of SHBG, and lower SHBG levels anticipated earlier puberty. These findings may be relevant to the occurrence of earlier puberty in recent decades.

Cited by 51 publications

References 39 publications

Impact of BMI on gonadorelin‐stimulated LH peak in premenarcheal girls with idiopathic central precocious puberty

Impact of BMI on gonadorelin‐stimulated LH peak in premenarcheal girls with idiopathic central precocious puberty

Causal risk factors for asthma in Mendelian randomization studies: A systematic review and meta‐analysis

Biomarkers of Insulin Resistance

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