Adiposity and weight gain during pregnancy associate independently with behavior of infant rhesus monkeys (<i>Macaca mulatta</i>)

Walker, Cheryl K.; VandeVoort, Catherine A.; Li, Chin Shang; Chaffin, Charles L.; Capitanio, John P.

doi:10.1002/dev.21744

Cited by 8 publications

(13 citation statements)

References 71 publications

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“…A systemic review of animal studies further suggests that maternal obesity is associated with offspring neurobehavioral disruptions as evidenced by elevated locomotor activity and anxiogenic behaviors (Menting et al, 2019). Rhesus macaque offspring of mothers with increased baseline adiposity or gestational weight gain display poor adaptability with exaggerated emotional responses and reduced interest in novel stimuli (Walker, VandeVoort, Li, Chaffin, & Capitanio, 2018). Correspondingly, they have greater suppression of cortisol following dexamethasone administration.…”

Section: Introductionmentioning

confidence: 99%

The placenta‐brain‐axis

Rosenfeld

2020

J of Neuroscience Research

140

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All mammalian species depend on the placenta, a transient organ, for exchange of gases, nutrients, and waste between the mother and conceptus. Besides serving as a conduit for such exchanges, the placenta produces hormones and other factors that influence maternal physiology and fetal development. To meet all of these adaptations, the placenta has evolved to become the most structurally diverse organ within all mammalian taxa. However, commonalities exist as to how placental responses promote survival against in utero threats and can alter the trajectory of fetal development, in particular the brain. Increasing evidence suggests that reactions of the placenta to various in utero stressors may lead to long‐standing health outcomes, otherwise considered developmental origin of health and disease effects. Besides transferring nutrients and gases, the placenta produces neurotransmitters, including serotonin, dopamine, norepinephrine/epinephrine, that may circulate and influence brain development. Neurobehavioral disorders, such as autism spectrum disorders, likely trace their origins back to placental disturbances. This intimate relationship between the placenta and brain has led to coinage of the term, the placenta‐brain‐axis. This axis will be the focus herein, including how conceptus sex might influence it, and technologies employed to parse out the effects of placental‐specific transcript expression changes on later neurobehavioral disorders. Ultimately, the placenta might provide a historical record of in utero threats the fetus confronted and a roadmap to understand how placenta responses to such encounters impacts the placental‐brain‐axis. Improved early diagnostic and preventative approaches may thereby be designed to mitigate such placental disruptions.

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Section: Introductionmentioning

confidence: 99%

The placenta‐brain‐axis

Rosenfeld

2020

J of Neuroscience Research

140

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“…Typically, this approach begins with combining BBA data with other existing data related to the process of interest—that is, the first step is often an archival study to show proof of concept. This was the approach taken in our initial study of airway hyperresponsiveness [ 36 ], maternal body condition and weight gain during pregnancy [ 60 ], social factors relating to autism spectrum disorder, and behavioral inhibition [ 14 ]. As it is evident, sometimes, these archival studies lead to publications, but more importantly, they can serve as preliminary data for grant proposals aimed at investigating underlying mechanisms.…”

Section: Discussionmentioning

confidence: 99%

“…Maternal obesity. There is growing evidence that maternal pre-pregnancy body mass index and gestational weight gain are associated with neurodevelopmental disorders in offspring (see numerous references in [ 60 ]). We identified n = 173 IMR infants that met inclusion criteria and assessed their BBA outcome measures against their dams’ pre-conception body condition score, and dams’ gestational weight gain.…”

Section: How Can Knowledge Of Animals’ Biobehavioral Organization Facilitate Better Science?mentioning

confidence: 99%

Knowledge of Biobehavioral Organization Can Facilitate Better Science: A Review of the BioBehavioral Assessment Program at the California National Primate Research Center

Capitanio

2021

Animals

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Animals vary on intrinsic characteristics such as temperament and stress responsiveness, and this information can be useful to experimentalists for identifying more homogeneous subsets of animals that show consistency in risk for a particular research outcome. Such information can also be useful for balancing experimental groups, ensuring animals within an experiment have similar characteristics. In this review, we describe the BioBehavioral Assessment Program at the California National Primate Research Center, which, since its inception in 2001, has been providing quantitative information on intrinsic characteristics to scientists for subject selection and balancing, and to colony management staff for management purposes. We describe the program and review studies relating to asthma, autism, behavioral inhibition, etc., where the BBA Program was used to select animals. We also review our work, showing that factors such as rearing, ketamine exposure, and prenatal experience can affect biobehavioral organization in ways that some investigators might want to control for in their studies. Attention to intrinsic characteristics of subject populations is consistent with the growing interest in precision medicine and can lead to a reduction in animal numbers, savings in time and money for investigators, and reduced distress for the animals.

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“…The assay was performed following the manufacturer's protocol. The assessment of infant plasma cortisol was conducted as previously described [17,18]. Briefly, the infants were separated from their mothers at 9 a.m. and blood samples were collected at 11 a.m. (Sample 1).…”

Section: Metabolite Extraction and Insulin Cytokine And Cortisol Meas...mentioning

confidence: 99%

Impact of Maternal Obesity on the Gestational Metabolome and Infant Metabolome, Brain, and Behavioral Development in Rhesus Macaques

et al. 2022

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Maternal gestational obesity is associated with elevated risks for neurodevelopmental disorder, including autism spectrum disorder. However, the mechanisms by which maternal adiposity influences fetal developmental programming remain to be elucidated. We aimed to understand the impact of maternal obesity on the metabolism of both pregnant mothers and their offspring, as well as on metabolic, brain, and behavioral development of offspring by utilizing metabolomics, protein, and behavioral assays in a non-human primate model. We found that maternal obesity was associated with elevated inflammation and significant alterations in metabolites of energy metabolism and one-carbon metabolism in maternal plasma and urine, as well as in the placenta. Infants that were born to obese mothers were significantly larger at birth compared to those that were born to lean mothers. Additionally, they exhibited significantly reduced novelty preference and significant alterations in their emotional response to stress situations. These changes coincided with differences in the phosphorylation of enzymes in the brain mTOR signaling pathway between infants that were born to obese and lean mothers and correlated with the concentration of maternal plasma betaine during pregnancy. In summary, gestational obesity significantly impacted the infant systemic and brain metabolome and adaptive behaviors.

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Adiposity and weight gain during pregnancy associate independently with behavior of infant rhesus monkeys (Macaca mulatta)

Cited by 8 publications

References 71 publications

The placenta‐brain‐axis

The placenta‐brain‐axis

Knowledge of Biobehavioral Organization Can Facilitate Better Science: A Review of the BioBehavioral Assessment Program at the California National Primate Research Center

Impact of Maternal Obesity on the Gestational Metabolome and Infant Metabolome, Brain, and Behavioral Development in Rhesus Macaques

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