Adiposity and insulin resistance moderate the links between neuroelectrophysiology and working and episodic memory functions in young adult males but not females

Larsen, Brittany; Klinedinst, Brandon S.; Wolf, Tovah; McLimans, Kelsey E.; Wang, Qian; Pollpeter, Amy; Li, Tianqi; Mohammadiarvejeh, Parvin; Fili, Mohammad; Grundy, John G.; Willette, Auriel A.

doi:10.1016/j.physbeh.2023.114321

Cited by 2 publications

(1 citation statement)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We did not find significant network CMR GLC associations with episodic and working memory (PC4 and PC5). However, we did find higher HOMA-IR to be associated with worse working memory, an effect also found in previous research (32, 33), suggesting that insulin resistance is a risk factor for working memory impairment. Unexpectedly, we did not find age group differences for episodic and working memory.…”

Section: Discussionsupporting

confidence: 89%

Peripheral insulin resistance attenuates cerebral glucose metabolism and impairs working memory in healthy adults

Deery,

Liang,

Di Paolo

et al. 2023

Preprint

View full text Add to dashboard Cite

Research suggests that cerebral metabolic rates of glucose (CMRGLC) decline with age. However, only a small body of research has taken into account partial volume effects in PET imaging and age-related reductions in cortical thickness. Separate research suggests that levels of peripheral insulin resistance may be a biomarker for functional brain changes. Thirty-six younger (mean 27.8 years) and 43 older (mean 75.5) participants completed a blood and cognitive tests battery and a simultaneous 90-minute MR/PET scan. Cortical thickness and CMRGLCwere derived using the Schaefer 100 atlas, and major subcortical structures. Insulin resistance was measured with the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). Older adults had lower CMRGLCthan younger adults across most regions, an effect that was mediated in part but not in full by age-related lower cortical thickness. Age x HOMA-IR interaction analysis showed that a 10% increase in insulin resistance was associated with 2% to 8% lower CMRGLCin younger adults across regions, with smaller reductions in older adults. Higher CMRGLCin the ventral attention, control and default networks was associated with better executive function, attention and processing seed. These results suggest that the age-related cerebral metabolism reductions are partly mediated by cortical atrophy, whereas insulin resistance associations with CMRGLCare moderated by age.

show abstract

Section: Discussionsupporting

confidence: 89%

Peripheral insulin resistance attenuates cerebral glucose metabolism and impairs working memory in healthy adults

Deery,

Liang,

Di Paolo

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Peripheral insulin resistance attenuates cerebral glucose metabolism and impairs working memory in healthy adults

Deery,

Liang,

Di Paolo

et al. 2024

npj Metab Health Dis

View full text Add to dashboard Cite

People with insulin resistance are at increased risk for cognitive decline. Insulin resistance has previously been considered primarily a condition of ageing but it is increasingly seen in younger adults. It is possible that impaired insulin function in early adulthood has both proximal effects and moderates or even accelerates changes in cerebral metabolism in ageing. Thirty-six younger (mean 27.8 years) and 43 older (mean 75.5) participants completed a battery of tests, including blood sampling, cognitive assessment and a simultaneous PET/MR scan. Cortical thickness and cerebral metabolic rates of glucose were derived for 100 regions and 17 functional networks. Older adults had lower rates of regional cerebral glucose metabolism than younger adults across the brain even after adjusting for lower cortical thickness in older adults. Higher fasting blood glucose was also associated with lower regional cerebral glucose metabolism in older adults. In younger adults, higher insulin resistance was associated with lower rates of regional cerebral glucose metabolism but this was not seen in older adults. The largest effects of insulin resistance in younger adults were in prefrontal, parietal and temporal regions; and in the control, salience ventral attention, default and somatomotor networks. Higher rates of network glucose metabolism were associated with lower reaction time and psychomotor speed. Higher levels of insulin resistance were associated with lower working memory. Our results underscore the importance of insulin sensitivity and glycaemic control to brain health and cognitive function across the adult lifespan, even in early adulthood.

show abstract

Adiposity and insulin resistance moderate the links between neuroelectrophysiology and working and episodic memory functions in young adult males but not females

Cited by 2 publications

References 70 publications

Peripheral insulin resistance attenuates cerebral glucose metabolism and impairs working memory in healthy adults

Peripheral insulin resistance attenuates cerebral glucose metabolism and impairs working memory in healthy adults

Peripheral insulin resistance attenuates cerebral glucose metabolism and impairs working memory in healthy adults

Contact Info

Product

Resources

About