Adiposity and Fat Distribution in relation to Inflammation and Oxidative Stress in a Relatively Lean Population of Chinese Women

Wu, Shenghui; Shu, Xiao‐Ou; Chow, Wong‐Ho; Xiang, Yong-Bing; Zhang, Xianglan; Cai, Qiuyin; Li, Honglan; Milne, Ginger L.; Wen, Wanqing; Ji, Bu‐Tian; Rothman, Nathaniel; Gao, Yu‐Tang; Zheng, Wei; Yang, Gong

doi:10.1155/2013/437076

Cited by 10 publications

(20 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…15 In a lean subject population, various markers of OS and inflammation were associated with BMI and central adiposity, measured by waist circumference. 16 Our study supports and extends previous findings of a linear positive correlation between obesity and OS, and highlights the relations between android fat deposition and increased OS. However, the impact of changes in central or android obesity rather than general weight on OS remains unclear.…”

Section: Discussionsupporting

confidence: 91%

Relation of Changes in Body Fat Distribution to Oxidative Stress

Kelli

Corrigan

Heinl

et al. 2017

The American Journal of Cardiology

View full text Add to dashboard Cite

Android fat is a surrogate measure of visceral obesity in the truncal region. Both visceral adiposity and oxidative stress (OS) are linked to cardiometabolic risk factors and clinical cardiovascular disease. However, whether body fat distribution (android vs gynoid) is associated with OS remains unknown. We hypothesized that increased android fat will be associated with greater OS. Body fat distribution and markers of OS, including plasma levels of reduced (cysteine and glutathione) and oxidized (cystine and glutathione disulfide) aminothiols, were estimated in 711 volunteers (67% female, 23% black, mean age 48 ± 11) enrolled in the Emory Georgia Tech Predictive Health study. At 1 year, 498 subjects had repeat testing. At baseline, anthropometric and fat distribution indexes, including body mass index, waist circumference, weight/hip ratio, and android and gynoid fat mass correlated with lower plasma concentrations of glutathione and higher cystine levels indicative of higher OS. At 1 year, the change in android but not gynoid fat mass or body mass index negatively correlated with the change in the plasma glutathione level after adjustment for cardiovascular risk factors. Increased body fat, specifically android fat mass, is an independent determinant of systemic OS, and its change is associated with a simultaneous change in OS, measured as plasma glutathione. In conclusion, our findings suggest that excess android or visceral fat contributes to the development of cardiovascular disease through modulating OS.

show abstract

Section: Discussionsupporting

confidence: 91%

Relation of Changes in Body Fat Distribution to Oxidative Stress

Kelli

Corrigan

Heinl

et al. 2017

The American Journal of Cardiology

View full text Add to dashboard Cite

show abstract

“…To the best of our knowledge, this finding has been reported previously in adults (33) , but not in children.…”

Section: Discussionsupporting

confidence: 68%

Waist-to-height ratio, inflammation and CVD risk in obese children

Olza

Aguilera

Gil-Campos

et al. 2014

Public Health Nutr.

View full text Add to dashboard Cite

Objective: To evaluate the association between waist-to-height ratio (WHtR) and specific biomarkers of inflammation, CVD risk and endothelial dysfunction in prepubertal obese children. Design: Prospective, multicentre case-control study matched by age and sex. Setting: Children were recruited between May 2007 and May 2010 from primarycare centres and schools in three cities in Spain (Cordoba, Santiago de Compostela and Zaragoza). Subjects: Four hundred and forty-six (223 normal weight and 223 obese) Caucasian prepubertal children aged 6-12 years. Results: WHtR was higher in the obese than in the normal-weight children. Blood pressure, waist circumference, weight, height, insulin, plasma lipids, leptin, resistin, abnormal neutrophil and monocyte counts, C-reactive protein, IL-6, IL-8, TNF-a, myeloperoxidase, soluble intercellular adhesion molecule-1, selectin and plasminogen activator inhibitor-1 levels were higher in the obese than in the normal-weight group. Adiponectin and HDL-cholesterol were lower and glucose and metalloproteinase-9 showed no differences. Resistin, TNF-a and active plasminogen activator inhibitor-1 were associated with WHtR, a sensitive indicator of central obesity. Conclusions: Our results lead to the hypothesis that changes in biomarker levels of insulin resistance, inflammation and CVD risk before puberty might induce metabolic consequences of obesity in obese children before reaching adulthood.

show abstract

“…Higher levels of UA have been repeatedly observed in patients with inflammation-related diseases, such as metabolic syndrome, diabetes and CHD (Choi, 2005; Culleton, 1999; Dehghan, 2008). As observed in our study and two other studies (Frohlich, 2000; Ruggiero, 2006), UA levels were positively correlated to levels of inflammatory markers as well as a history of chronic inflammation-related diseases (Dorjgochoo, 2011a; Fang, 2000; Hershfield, 2010; Kodama, 2009; Sundstrom, 2005; Wu, 2013). …”

Section: Discussionsupporting

confidence: 90%

“…Chronic cigarette smoking is associated with higher levels of F 2 -IsoPs but not the metabolite F 2 -IsoP-M in urine (Dorjgochoo, 2011b; Seet, 2011). However, it appears that urinary F 2 -IsoP-M is a more sensitive biomarker for obesity than its parent compound F 2 -IsoPs (Dorjgochoo, 2011b; Wu, 2013). Therefore, it is reasonable to take advantage of multiple rather than single F 2 -IsoP markers when studying diverse health conditions or disease mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Uric acid correlates to oxidation and inflammation in opposite directions in women

Shu

Milne

et al. 2015

Biomarkers

Self Cite

View full text Add to dashboard Cite

Objective To evaluate the association of uric acid (UA) levels with a panel of markers of oxidative stress and inflammation. Methods Plasma UA levels, along with a panel of oxidative stress and inflammatory markers, were measured in 755 Chinese women. Results Plasma UA levels were inversely associated with urinary levels of the oxidative stress marker F2-isoprostanes and positively correlated to levels of inflammatory markers such as C-reactive protein and some proinflammatory cytokines (tumor necrosis factor-α and interleukin-6) in blood as well as prostaglandin E2 metabolites in urine. Conclusions Plasma UA levels correlate to oxidation and inflammation biomarkers in opposite directions in women.

show abstract

Adiposity and Fat Distribution in relation to Inflammation and Oxidative Stress in a Relatively Lean Population of Chinese Women

Cited by 10 publications

References 38 publications

Relation of Changes in Body Fat Distribution to Oxidative Stress

Relation of Changes in Body Fat Distribution to Oxidative Stress

Waist-to-height ratio, inflammation and CVD risk in obese children

Uric acid correlates to oxidation and inflammation in opposite directions in women

Contact Info

Product

Resources

About