Adipositas und Typ 2 Diabetes

Toplak, Hermann; Hoppichler, Friedrich; Wascher, Thomas C.; Schindler, Karin; Ludvik, Bernhard

doi:10.1007/s00508-016-0986-9

Cited by 21 publications

(14 citation statements)

References 34 publications

(16 reference statements)

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“…It has also been reported that hypoglycemic drugs such as metformin regulate the balance of intestinal microbiota and achieve the purpose of treating diabetes [29]. It was discovered that the abundance of Clostridium in the intestine of diabetic rats was signi cantly reduced [10]. At the same time, Denmark's study of 134 pre-diabetes patients reported that the abundance of Clostridium was signi cantly reduced [27].…”

Section: Discussionmentioning

confidence: 99%

“…To quantify the bacterial species of interest in all subjects, qPCR was used to analyze the original DNA samples using bacterial species-speci c primers. The qPCR data were expressed as log 10 copies per mg total microbial DNA as showed in Figure 1. The abundance of Lactobacillus genus and Clostridium genus was lower in newly diagnosed T2DM group than in the NC group (P<0.05).…”

Section: Genotyping Of Ometin-1 Gene Variation (Rs2274907)mentioning

confidence: 99%

“…Gut microbiota closely related to the obesity [9], and obesity is an important risk factor for T2DM [10]. Gut microbiota affects the development of obesity and T2DM mainly through the energy acquisition in the intestine, regulating fat storage and affecting adipocytes, and regulating the in ammation induced by metabolic endotoxemia [11].…”

Section: Introductionmentioning

confidence: 99%

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Correlation study on gut microbiota and omentin-1 gene polymorphism in Uyghur newly diagnosed type 2 diabetes

Nuli

Shan

Zhang

et al. 2020

Preprint

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Background: Type 2 diabetes (T2DM) is a top risk factor for health in China. Gut microbiota, genetic factors and lipids metabolism play important role in development of T2DM. In this study, we investigated the relationship between the gut microbiota and omentin-1 gene polymorphism to explore the interaction between host gene and gut microbiota in Uyghur T2DM. Methods: A total of 98 newly diagnosed Uyghur T2DM patients and 99 healthy normal controls (NC) enrolled into this study according to inclusion criteria. The total DNAs was extracted from the fecal microbiota. Abundance of the Lactobacillus genus, Bacteroides thetaiotaomicron and Clostridium in the gut microbiota was determined with 16S rDNA gene Real-time fluorescence quantitative PCR amplification. PCR-PFLP was applied to determine the genotypes of Val109Asp variant (rs2274907) in the Omentin-1 gene. And the relationship between rs2274907 and gut microbiota was assessed. Results: There were no significant differences of the Val109Asp variant (rs2274907) between T2DM and NC group. The abundance of Lactobacillus genus and Clostridium genus was lower in newly diagnosed T2DM group than in the NC group (P<0.05). Serum insulin, LDL-C, the abundances of Lactobacillus genus and Clostridium genus were the risk factors of T2DM. (OR=1.094 95%CI 1.014-1.180), (OR=3.868 95%CI 1.250-11.971), (OR=0.288 95%CI 0.145-0.571), (OR=0.044 95%CI 0.012-0.154). Conclusions: The abundance of Lactobacillus and Clostridium genus may be related to the pathogenesis of new-onset T2DM in Uyghur population, the mechanism of which needs to be further studied. The interactive relationship between the gut microbiota and omentin-1 gene polymorphism in newly diagnosed T2DM was not observed in this study.

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Section: Discussionmentioning

confidence: 99%

Section: Genotyping Of Ometin-1 Gene Variation (Rs2274907)mentioning

confidence: 99%

See 1 more Smart Citation

Correlation study on gut microbiota and omentin-1 gene polymorphism in Uyghur newly diagnosed type 2 diabetes

Nuli

Shan

Zhang

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 98%

“…Gut microbiota closely related to the obesity [9], and obesity is important risk factor of T2DM [10].…”

mentioning

confidence: 99%

Correlation study on gut microbiota and omentin-1 gene polymorphism in Uyghur newly diagnosed type 2 diabetes

Nuli

Shan

Zhang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Type 2 diabetes (T2DM) is a top risk factor for health in China. Gut microbiota, genetic factors and lipids metabolism play important role in development of T2DM. In this study, we investigated the relationship between the gut microbiota and omentin-1 gene polymorphism to explore host gene and gut microbiota interaction in Uyghur T2DM.Methods: A total of 98 newly diagnosed Uyghur T2DM patients and 99 healthy normal controls (NC) enrolled into this study according to inclusion criteria. The total DNAs were extracted from the fecal microbiota. Abundant of the Lactobacillus genus, Bacteroides thetaiotaomicron and Clostridium in the gut microbiota were determined with 16S rDNA gene Real-time fluorescence quantitative PCR amplification. PCR-PFLP was applied to determine the genotypes of Val109Asp variant (rs2274907) in the Omentin-1 gene. And the relationship between rs2274907 and gut microbiota was assessed.Results : There were no significant differences between the genotypes of Val109Asp variant (rs2274907) of T2DM and control group. The abundances of Lactobacillus genus and Clostridium genus were lower in newly diagnosed T2DM group, compared with NC group ( P <0.05). Serum insulin, LDL-C, the abundances of Lactobacillus genus and Clostridium genus were the risk factor of T2DM. (OR=1.094 95%CI 1.014-1.180), (OR=3.868 95%CI 1.250-11.971), (OR=0.288, 95%CI 0.145-0.571), (OR=0.044, 95%CI 0.012-0.154).Conclusions: The abundance of Lactobacillus and Clostridium genus may be related to the pathogenesis of new-onset T2DM in Uyghur population, the mechanism of which needs to be further studied. The interaction relationship between the gut microbiota and omentin-1 gene polymorphism in newly diagnosed T2DM was not observed in this study.

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Cardiometabolic syndrome among general adult population in Ghana: The role of lipid accumulation product, waist circumference‐triglyceride index, and triglyceride‐glucose index as surrogate indicators

Anto,

Frimpong,

Boadu

et al. 2023

Health Science Reports

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Background: Visceral obesity and insulin resistance contribute to developing cardiometabolic syndrome (MetS). We investigated the predictive abilities of lipid accumulation product (LAP), waist circumference-triglyceride index (WTI), and triglyceride-glucose (TyG) index for MetS screening among the general Ghanaian adults. Methods:The final prospective analysis included 4740 healthy adults aged 30-90 years from three communities comprising Ejisu, Konongo, and Ashanti Akim Agogo in Ghana. Self-structured questionnaire pretested was used to collect sociodemographic, anthropometric, and clinical data. Blood samples were taken after fasting to measure glucose and lipid levels. LAP, WTI, and TyG were calculated from standard equations. MetS was defined by the International Diabetes Federation criteria. Receiver operating characteristic (ROC) curves and multivariable logistic regression were utilized to evaluate the potential of the three indices in identifying MetS.Results: Of the 4740 participants, 39.7% had MetS. MetS was more common in females (50.3%) than in males (22.2%). Overall, LAP ≥ 27.52 yielded as the best index for MetS with the highest area under the ROC curve (AUC) (0.866). At cut-off LAP point of ≥23.87 in males and ≥33.32 in females, an AUC of 0.951 and 0.790 was identified in MetS prediction, respectively. LAP was an independent risk measure of MetS for both males (45.6-fold) and females (3.7-fold) whereas TyG was an independent risk measure for females (3.7-fold) only.

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Adipositas und Typ 2 Diabetes

Cited by 21 publications

References 34 publications

Correlation study on gut microbiota and omentin-1 gene polymorphism in Uyghur newly diagnosed type 2 diabetes

Correlation study on gut microbiota and omentin-1 gene polymorphism in Uyghur newly diagnosed type 2 diabetes

Correlation study on gut microbiota and omentin-1 gene polymorphism in Uyghur newly diagnosed type 2 diabetes

Cardiometabolic syndrome among general adult population in Ghana: The role of lipid accumulation product, waist circumference‐triglyceride index, and triglyceride‐glucose index as surrogate indicators

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