Adipose Tissue Mediates Associations of Birth Weight with Glucose Metabolism Disorders in Children

Wu, Yunpeng; Yu, Xinting; Yu, Li; Ge, Li; Cheng, Hong; Xiao, Xiangyu; Mi, Jie; Gao, Shan; Willi, Steven M.; Li, Ming

doi:10.1002/oby.22421

Cited by 8 publications

(16 citation statements)

References 46 publications

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“…The increase in childhood obesity worldwide is recognized as one of the most severe public health problems. The evidence of the association between childhood obesity and parameters of MetS is increasing (7,16,17). Adipocytokines and genetic background are known to be important in the pathogenesis of MetS (18,19).…”

Section: Discussionmentioning

confidence: 99%

Association of Total and High Molecular Weight Adiponectin with Components of Metabolic Syndrome in Mexican Children

Gomez¹,

Moreno-Mascareño²,

Angulo-Rojo³

et al. 2020

Jcrpe

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Childhood obesity linked to metabolic alterations, tend to appear simultaneously with altered adipocytokines, suggesting a role in pathogenetic development. Low circulating level of total and high molecular weight (HMW) adiponectin have been associated with components of the metabolic syndrome (MetS) and could represent an independent risk factor with potential use as a biomarker. To examine the prevalence of MetS in Mexican school children and to investigate the association of total and HMW adiponectin levels with biochemical parameters related to MetS. Methods: The study included a population of boys and girls, from 8 to 11 years old. Anthropometric and biochemical parameters were evaluated according to weight and MetS status. A correlation analysis was fitted to establish an association between adiponectin concentrations and metabolic indicators. Results: One-hundred and fifty five children participated (59.4% females) from 8-11 years of age. The prevalence of MetS was of 10.3%. Impaired biochemical parameters, including total and HMW adiponectin, were associated with obesity. The adiponectin level was significantly lower in MetS than in non-MetS subjects (4.5 vs. 5.4 μg/mL). Total-but not HMW adiponectin concentration was negatively correlated with blood pressure, fasting insulin, fasting blood sugar and Homeostatic Model Assessment for Insulin Resistance. Conclusion: In young children, the total adiponectin level is associated with impaired biochemical parameters of carbohydrate metabolism and could be an excellent early predictor of metabolic complications.

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Section: Discussionmentioning

confidence: 99%

Association of Total and High Molecular Weight Adiponectin with Components of Metabolic Syndrome in Mexican Children

Gomez¹,

Moreno-Mascareño²,

Angulo-Rojo³

et al. 2020

Jcrpe

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“…Limited prospective studies have investigated the mediating effects of birth weight on incident T2D risk through insulin resistance, sex hormonebinding globulin, E-selectin, systolic blood pressure, and adiponectin. 9,10 Our study is the first, to our knowledge, to assess simultaneously associations of birth weight with multiple lipoproteins, lipids, amino acids, and FA and the role of these metabolites in potentially mediating the association between birth weight and T2D.…”

Section: Discussionmentioning

confidence: 99%

Associations of birth weight, plasma metabolome in adulthood and risk of type 2 diabetes

Wang,

Zhuang,

Zhao

et al. 2024

Diabetes Metabolism Res

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AimsWe aimed to examine the longitudinal associations of birth weight with plasma metabolites in adulthood, and further quantify the proportions of the links between birth weight and incident adult type 2 diabetes (T2D) that were mediated by plasma metabolites.Materials and MethodsA total of 62,033 participants with complete nuclear magnetic resonance metabolomics and birth weight data from the UK Biobank were included in this study. Linear regression was used to assess the associations between birth weight and metabolites. Cox regression was used to estimate hazard ratios for T2D associated with metabolites. We further performed mediation analyses to estimate the extent to which metabolites might mediate the association between birth weight and T2D risk.ResultsLow birth weight was associated with the adverse metabolic responses across multiple metabolic pathways, including lipoprotein subclasses, amino acids, fatty acids (FA), and inflammation. Metabolites associated with higher birth weight tended to be associated with a lower risk of T2D (Pearson correlation coefficient: −0.85). A total of 62 metabolites showed statistically significant mediation effects in the protective association of higher birth weight and T2D risk, including large‐sized very low‐density lipoprotein particles and triglyceride concentrations as well as saturated, and monounsaturated FA and glycoprotein acetyls.ConclusionsWe identified a range of metabolites that reflect the adult metabolic response to birth weight, some of which might lie on the pathway between birth weight and adult T2D risk.

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“…The increase in obesity, especially adolescent obesity, is considered to be a serious public health problem. More and more evidence shows that there is an important relationship between obesity and MetS ( 25 , 26 ). Genetic background and environmental factors such as diet play a crucial role in the effluence of MetS.…”

Section: Discussionmentioning

confidence: 99%

GPHB5 Is a Biomarker in Women With Metabolic Syndrome: Results From Cross-Sectional and Intervention Studies

Xiang

Zhang

et al. 2022

Front. Endocrinol.

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BackgroundAnimal studies have found that GPHB5 has a similar effect on system metabolism as TSH. However, the relationship between GPHB5 and metabolic diseases remains unknown. This study investigates the relationship between GPHB5 and MetS in young women.MethodsBioinformatics analysis was undertaken to explore the relationship between GPHB5 and metabolic-related genes and signaling pathways. EHC and OGTT were performed on all individuals. Lipid-infusion, physical activity, and cold-exposure tests were performed on healthy individuals. Serum GPHB5 concentrations were measured by an ELISA kit.ResultsPPI network showed that 11 genes interacted with GPHB5, in which POMC and KISS1R were involved in glucose and lipid metabolism. GO analysis showed 56 pathways for BP and 16 pathways for MF, in which OPRM1 and MCR families were related to energy metabolism. KEGG analysis found that GPHB5 is associated with lipolysis and neuroactive ligand-receptor interaction pathways. The levels of circulating GPHB5 were significantly increased, while serum adiponectin levels were lower in MetS women compared with healthy women. Obese/overweight individuals had lower adiponectin levels and higher GPHB5 levels. Circulating GPHB5 levels were positively correlated with BMI, WHR, blood pressure, FBG, 2 h-BG, HbA1c, FIns, 2h-Ins, LDL-C, FFA, HOMA-IR, and AUCg, etc. but negatively correlated with HDL-C, adiponectin, and M-values. Serum GPHB5 levels did not change significantly during the OGTT, EHC, and lipid infusion. Physical activity and cold-exposure tests did not lead to changes in GPHB5 levels. GLP-1RA treatment resulted in a significant decrease in serum GPHB5 levels.ConclusionsGPHB5 may be a biomarker for MetS.

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Adipose Tissue Mediates Associations of Birth Weight with Glucose Metabolism Disorders in Children

Cited by 8 publications

References 46 publications

Association of Total and High Molecular Weight Adiponectin with Components of Metabolic Syndrome in Mexican Children

Association of Total and High Molecular Weight Adiponectin with Components of Metabolic Syndrome in Mexican Children

Associations of birth weight, plasma metabolome in adulthood and risk of type 2 diabetes

GPHB5 Is a Biomarker in Women With Metabolic Syndrome: Results From Cross-Sectional and Intervention Studies

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