Adipose Tissue-Liver Cross Talk in the Control of Whole-Body Metabolism: Implications in Nonalcoholic Fatty Liver Disease

Azzu, Vian; Vacca, Michèle; Virtue, Samuel; Allison, Michael; Vidal-Puig, António

doi:10.1053/j.gastro.2019.12.054

Cited by 174 publications

(147 citation statements)

References 171 publications

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“…The independent aspect of metabolic liver disease that can be present alongside other liver diseases-including social alcohol use-is currently at the center of an ongoing academic debate [9]. From a pathophysiological point of view, the most obvious independent contribution of NAFLD is with regards to cardiovascular diseases [10][11][12]. Those findings are in parts explained by an increase in systemic inflammation caused by inflammatory processes in the liver.…”

Section: Introductionmentioning

confidence: 99%

Incident Dementia in Elderly Patients with Nonalcoholic Fatty Liver Disease in Germany

Labenz

Kostev²,

Kaps

et al. 2020

Dig Dis Sci

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Dementia and NAFLD are two frequent conditions that share underlying risk factors mainly in the realm of metabolic disease. Additionally, an association between NAFLD and brain aging has been proposed. Therefore, we investigated the hypothesis if NAFLD is an independent risk factor for emerging dementia. In this population-based cohort study, elderly patients (≥ 65 years) with NAFLD diagnosed between 2000 and 2015 were matched 1:1 to a cohort without NAFLD based on ICD-10 coding in the Disease Analyzer database. Matching criteria were age, sex, physician, index year, and co-diagnoses associated with dementia. The primary outcomes of this study were all-cause dementia diagnoses, the incidence of vascular dementia, and antidementive drug prescription. A total of 22,317 patients with NAFLD were matched to 22,317 patients without NAFLD. Within 10 years of the index date, 16.0% of patients with NAFLD and 15.6% of the patients without NAFLD were diagnosed with dementia. On Cox regression analysis, there is no association between NAFLD and the incidence of all-cause dementia (HR 0.97, 95% CI 0.92-1.04), vascular dementia (HR 0.89, 95% CI 0.78-1.02), or the new prescription of antidementive therapy (HR 0.87, 95% CI 0.76-1.01). In sensitivity analyses, there was no association between NAFLD and dementia in different age-groups as well as men or women. In conclusion, in this database study of elderly patients coded with NAFLD no independent association with incident dementia was detected. Risk assessment regarding dementia in patients with NAFLD should be carried out in the same way as for metabolic burdened patients.

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Section: Introductionmentioning

confidence: 99%

Incident Dementia in Elderly Patients with Nonalcoholic Fatty Liver Disease in Germany

Labenz

Kostev²,

Kaps

et al. 2020

Dig Dis Sci

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“…A recent review suggests that adipose tissue function is a critical driver of NAFLD and NASH. Cytokines and hormones secreted by adipose tissue could affect the liver by regulating the lipid ux and affecting hepatocyte function via exosomal signaling [27]. Skeletal muscle is also regarded as an endocrine organ [28] that regulates myokine secretion.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Companion-Intensive Multi-aspect Weight Management in Chinese Adults with Obesity: A Six-Month Multicenter Randomized Clinical Trial

Jiang

Huang

et al. 2020

Preprint

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Background: Obesity is a globally increasing health epidemic requiring early lifestyle intervention. Our main objective was to examine the effectiveness of companion-intensive multi-aspect weight management (CIMWM) in Chinese adults with obesity.Methods: In this 6-month, prospective, open-label, multicenter, randomized controlled clinical trial, we recruited 272 obese adults aged 18–50 years with a body mass index (BMI) ≥28.0 kg/m2 and capable of using smartphones. CIMWM (n=136) offered both daily online instructions and monthly face-to-face guidance by physicians, dietitians, and health managers along with the provision of meal replacements in the first 3 months. Traditional multi-aspect weight management (TMWM, n=136) provided monthly face-to-face guidance by the same panel of professionals and the same meal replacements as CIMWM group, but required subjects to complete daily self-monitoring instead of offering daily online instructions. Body composition and metabolic parameters were assessed at baseline, 1, 2, 3, and 6 months by physicians. Primary outcomes were the clinically-significant weight loss and changes in BMI and body composition.Results: Participants in both groups showed significantly reduced BMI, body fat mass (BFM), visceral fat area (VFA), and HOMA-IR (P<0.05). CIMWM was shown to be superior to TMWM in the improvement of clinically-significant weight loss, BMI, total cholesterol (TC), the body composition parameters BFM and the skeletal muscle mass-to-visceral fat area ratio (S/V) (P<0.05). The non-alcoholic fatty liver disease score (NFS) was negatively related to S/V at baseline. After weight management, NFS was lowered among individuals with levels in the highest tertile (P<0.05). Metabolic memory in terms of the continuous reduction of BMI, BFM, and TC was retained up to 6 months in spite of participants transferring to self-monitoring assessment in the final 3 months.Conclusions: The CIMWM strategy in obese Chinese adults is proved to be more effective than TMWM in weight loss, and motivates greater adherence to intervention and lifestyle reprogramming.Trial registration: Chinese Clinical Trial Registry, ChiCTR1800017463, Registered July 31, 2018, retrospectively registry. http://www.chictr.org.cn/showproj.aspx?proj=29649

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“…A recent review suggests that adipose tissue function is a critical driver of NAFLD and NASH. Cytokines and hormones secreted by adipose tissue could affect the liver by regulating the lipid ux and affecting hepatocyte function via exosomal signaling [26]. Skeletal muscle is also regarded as an endocrine organ [27] that regulates myokine secretion.…”

Section: Discussionmentioning

confidence: 99%

Companion-Intensive Multi-aspect Weight Management in Chinese Adults with Obesity: A Six-Month Multicenter Randomized Clinical Trial

Jiang

Huang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Obesity is a globally increasing health epidemic requiring early lifestyle intervention. Our main objective was to examine the effectiveness of companion-intensive multi-aspect weight management (CIMWM) for Chinese adults with obesity. Methods In this 6-month, prospective, open-label, multicenter, randomized controlled clinical trial, we included 272 obese adults aged 18–50 years with a body mass index (BMI) ≥ 28.0 kg/m2 and capable of using smartphones. CIMWM (n = 136) offered both daily online instructions and monthly face-to-face guidance by physicians, dietitians, and health managers along with the provision of meal replacements in the first 3 months. Traditional multi-aspect weight management (TMWM, n = 136) provided monthly face-to-face guidance by the above-mentioned professionals and required daily self-monitoring. Measurements of body composition and metabolic parameters were assessed face-to-face at baseline, 1, 2, 3, and 6 months by physicians. Primary outcomes were the changes in BMI and body composition. Results All participants showed significantly reduced BMI, body fat mass (BFM), visceral fat area (VFA), and HOMA-IR (P < 0.05). CIMWM was shown to be superior to TMWM in the improvement of BMI, alanine aminotransferase (ALT), and the body composition parameters BFM and VFA (P < 0.05). The relationship of baseline non-alcoholic fatty liver disease score (NFS) was positively related to the skeletal muscle mass-to-visceral fat area ratio (S/V). Additionally, the weight management program was beneficial in lowering the NFS among subjects with levels in the highest tertile (P < 0.05). Metabolic memory in terms of the continuous reduction of BMI, VFA, and ALT was retained up to 6 months in spite of participants transferring to self-monitored assessment in the final 3 months. Conclusions The CIMWM strategy in obese Chinese adults proved to be more effective than TMWM, and motivates greater adherence to intervention and lifestyle reprogramming. Trial registration: ChiCTR1800017463, Registered 31 July 2018, retrospectively registry. http://www.chictr.org.cn/showproj.aspx?proj=29649

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Adipose Tissue-Liver Cross Talk in the Control of Whole-Body Metabolism: Implications in Nonalcoholic Fatty Liver Disease

Cited by 174 publications

References 171 publications

Incident Dementia in Elderly Patients with Nonalcoholic Fatty Liver Disease in Germany

Incident Dementia in Elderly Patients with Nonalcoholic Fatty Liver Disease in Germany

Effectiveness of Companion-Intensive Multi-aspect Weight Management in Chinese Adults with Obesity: A Six-Month Multicenter Randomized Clinical Trial

Companion-Intensive Multi-aspect Weight Management in Chinese Adults with Obesity: A Six-Month Multicenter Randomized Clinical Trial

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