Adipose tissue lipolysis and circulating lipids in acute and subacute critical illness: Effects of shock and treatment

Ilias, Ιoannis; Vassiliadi, Dimitra; Θεοδωρακοπούλου, Μαρία; Boutati, Eleni; Maratou, Eirini; Mitrou, Panagiota; Nikitas, Nikolaos F.; Apollonatou, Sofia; Dimitriadis, George; Armaganidis, Apostolos; Dimopoulou, Ioanna

doi:10.1016/j.jcrc.2014.06.003

Cited by 35 publications

(34 citation statements)

References 32 publications

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“…This suggests that the patients are undergoing excessive fatty acid beta-oxidation and oxidative stress. In addition to the liver, adipose tissue plays a strong role in the circulating lipid profile, with an increase in TGs and free fatty acids in particular, and is actively influenced in critical illness (47). Those EVD patients with fatal outcomes had increases (>2 log2 FC) in TGs with longer fatty acid chains (average of 55 carbons) that were more polyunsaturated (average five double bonds) compared with those that decreased (< −2 log2 FC; average of 44 carbons and 1.8 double bonds) vs. healthy controls.…”

Section: Resultsmentioning

confidence: 99%

Plasma lipidome reveals critical illness and recovery from human Ebola virus disease

Kyle

Burnum-Johnson

Wendler

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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Ebola virus disease (EVD) often leads to severe and fatal outcomes in humans with early supportive care increasing the chances of survival. Profiling the human plasma lipidome provides insight into critical illness as well as diseased states, as lipids have essential roles as membrane structural components, signaling molecules, and energy sources. Here we show that the plasma lipidomes of EVD survivors and fatalities from Sierra Leone, infected during the 2014–2016 Ebola virus outbreak, were profoundly altered. Focusing on how lipids are associated in human plasma, while factoring in the state of critical illness, we found that lipidome changes were related to EVD outcome and could identify states of disease and recovery. Specific changes in the lipidome suggested contributions from extracellular vesicles, viremia, liver dysfunction, apoptosis, autophagy, and general critical illness, and we identified possible targets for therapies enhancing EVD survival.

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Section: Resultsmentioning

confidence: 99%

Plasma lipidome reveals critical illness and recovery from human Ebola virus disease

Kyle

Burnum-Johnson

Wendler

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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“…Next to a deregulated glucose metabolism, the pathogenesis of sepsis is also known to influence fatty acid metabolism. Decades ago, it has already been described that lipolysis is upregulated in white adipose tissue (WAT) during the early phase of endotoxemia and sepsis (Forse et al, 1987), a finding that was more recently confirmed by several other studies (Wellhoener et al, 2011;Ilias et al, 2014;Rittig et al, 2016). Consequently, plasma TGs and FFA levels have been found to be increased up to 4-fold in septic patients compared to healthy individuals (Scholl et al, 1984;Lanza-Jacoby & Tabares, 1990;Nogueira et al, 2008).…”

Section: Lipolysismentioning

confidence: 86%

Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?

2018

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Sepsis is a highly lethal and urgent unmet medical need. It is the result of a complex interplay of several pathways, including inflammation, immune activation, hypoxia, and metabolic reprogramming. Specifically, the regulation and the impact of the latter have become better understood in which the highly catabolic status during sepsis and its similarity with starvation responses appear to be essential in the poor prognosis in sepsis. It seems logical that new interventions based on the recognition of new therapeutic targets in the key metabolic pathways should be developed and may have a good chance to penetrate to the bedside. In this review, we concentrate on the pathological changes in metabolism, observed during sepsis, and the presumed underlying mechanisms, with a focus on the level of the organism and the interplay between different organ systems.

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“…The visceral adipose tissue (VAT) was identified as critical source of bioactive proteins—so-called adipokines—during inflammatory diseases [1, 2]. By directly regulating hyperglycemia, glucose intolerance, and insulin resistance, adipokines function as prognostic indicators in several diseases [3, 4].…”

Section: Introductionmentioning

confidence: 99%

Elevated Omentin Serum Levels Predict Long-Term Survival in Critically Ill Patients

et al. 2016

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Introduction. Omentin, a recently described adipokine, was shown to be involved in the pathophysiology of inflammatory and infectious diseases. However, its role in critical illness and sepsis is currently unknown. Materials and Methods. Omentin serum concentrations were measured in 117 ICU-patients (84 with septic and 33 with nonseptic disease etiology) admitted to the medical ICU. Results were compared with 50 healthy controls. Results. Omentin serum levels of critically ill patients at admission to the ICU or after 72 hours of ICU treatment were similar compared to healthy controls. Moreover, circulating omentin levels were independent of sepsis and etiology of critical illness. Notably, serum concentrations of omentin could not be linked to concentrations of inflammatory cytokines or routinely used sepsis markers. While serum levels of omentin were not predictive for short term survival during ICU treatment, low omentin concentrations were an independent predictor of patients' overall survival. Omentin levels strongly correlated with that of other adipokines (e.g., leptin receptor or adiponectin), which have also been identified as prognostic markers in critical illness. Conclusions. Although circulating omentin levels did not differ between ICU-patients and controls, elevated omentin levels were predictive for an impaired patients' long term survival.

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Adipose tissue lipolysis and circulating lipids in acute and subacute critical illness: Effects of shock and treatment

Cited by 35 publications

References 32 publications

Plasma lipidome reveals critical illness and recovery from human Ebola virus disease

Plasma lipidome reveals critical illness and recovery from human Ebola virus disease

Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?

Elevated Omentin Serum Levels Predict Long-Term Survival in Critically Ill Patients

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