Adipose tissue lipid metabolism: lipolysis

Cho, Chung Hwan; Patel, Sanil; Rajbhandari, Prashant

doi:10.1016/j.gde.2023.102114

Cited by 4 publications

(1 citation statement)

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“…Lipolysis accompanied by activation of arachidonic acid metabolism is an essential process of fat breakdown in the regulation of insulin sensitivity and systemic energy metabolism. 29 Activation of the FGF21 axis in animals regulates lipolysis in WAT, therefore directly implicating eosinophils in this process. 30 , 31 Moreover, human eosinophils are known to constitutively and abundantly express eoxins, such as 15 lipoxygenase 1 (15LO1) (ALOX15), which could be one way adipose eosinophils participate in lipolytic process.…”

Section: Part 1: Impact Of Eosinophils On Adipocytesmentioning

confidence: 99%

Eosinophil biology from the standpoint of metabolism: implications for metabolic disorders and asthma

Haruna,

Berdnikovs,

Nie

2024

Journal of Leukocyte Biology

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Eosinophils, recognized for their immune and remodeling functions and participation in allergic inflammation, have recently garnered attention due to their impact on host metabolism, especially in the regulation of adipose tissue. Eosinophils are now known for their role in adipocyte beiging, adipokine secretion, and adipose tissue inflammation. This intricate interaction involves complex immune and metabolic processes, carrying significant implications for systemic metabolic health. Importantly, the interplay between eosinophils and adipocytes is bidirectional, revealing the dynamic nature of the immune-metabolic axis in adipose tissue. While the homeostatic regulatory role of eosinophils in the adipose tissue is appreciated, this relationship in the context of obesity or allergic inflammation is much less understood. Mechanistic details of eosinophil-adipose interactions, especially the direct regulation of adipocytes by eosinophils, are also lacking. Another poorly understood aspect is the metabolism of the eosinophils themselves, encompassing metabolic shifts during eosinophil subset transitions in different tissue microenvironments, along with potential effects of host metabolism on the programming of eosinophil hematopoiesis and the resulting plasticity. This review consolidates recent research in this emerging and fascinating frontier of eosinophil investigation, identifying unexplored areas and presenting innovative perspectives on eosinophil biology in the context of metabolic disorders and associated health conditions, including asthma.

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Section: Part 1: Impact Of Eosinophils On Adipocytesmentioning

confidence: 99%