Adipose tissue is influenced by hypoxia of obstructive sleep apnea syndrome independent of obesity

Thorn, Clare; Knight, Bridget; Pastel, Emilie; McCulloch, Laura; Patel, Bimal; Shore, Angela C.; Kos, Katarina

doi:10.1016/j.diabet.2016.12.002

Cited by 25 publications

(22 citation statements)

References 44 publications

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“…As shown in Table 1 , of the 63 studies retained for analysis, 14 were conducted in China ( 27 , 39 , 46 , 50 , 51 , 54 , 55 , 58 , 65 , 73 , 77 , 81 , 82 , 86 ), eight in the USA ( 26 , 28 , 34 , 38 , 56 , 76 , 78 , 83 ), six in Greece ( 37 , 43 , 47 , 49 , 58 , 64 ), six in Japan ( 29 – 31 , 41 , 42 , 44 ), six in Turkey ( 12 , 57 , 62 , 67 , 68 , 70 ), three in Italy ( 59 , 63 , 87 ), 3 in Brazil ( 45 , 53 , 72 ), three in Spain ( 36 , 60 , 71 ), two in Sweden ( 66 , 84 ), two in India ( 79 , 85 ), one in Ireland ( 32 ), one in Germany ( 35 ), one in Thailand ( 40 ), one in Finland ( 48 ), one in Canada ( 52 ), one in the UK ( 74 ), one in Croatia ( 80 ), one in Australia ( 33 ), one in Taiwan ( 69 ), and one in Belgium ( 75 ). With regard to ethnicity, 28 studies were performed with Caucasians ( 12 ,…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Serum and Plasma Interleukin-6 Levels in Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

et al. 2020

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Obstructive sleep apnea syndrome (OSAS) is considered a low-grade chronic inflammatory disease. Interleukin-6 (IL-6) is one of the most significant inflammatory markers and an excellent proxy for the inflammatory/immune system. The present meta-analysis and meta-regression aimed at comparing plasma and serum levels of IL-6 between individuals (children and adults) with OSAS and healthy controls. Four databases, PubMed/Medline, Scopus, Cochrane Library, and Web of Science, were comprehensively searched to retrieve articles published up to December, 2019, with no further restrictions. RevMan 5.3 software was used to calculate the crude mean difference (MD) and 95% confidence interval (CI). The results of funnel plots and meta-regression were analyzed by the CMA 2.0 software. Sixty-three studies (57 with adults; six with children) were included in the present meta-analysis. For adults, 37 studies reported significantly higher serum IL-6 levels and 20 reported significantly higher plasma IL-6 levels for those with OSAS than for healthy controls [pooled MD of 2.89 pg/ml ( P < 0.00001) and pooled MD of 2.89 pg/ml ( P < 0.00001), respectively]. The pooled analysis of serum and plasma IL-6 levels in children with OSAS compared with controls revealed that only the MD of plasma IL-6 levels was significant (MD = 0.84 pg/ml, P = 0.004). Results of the meta-regression showed that greater age was associated with higher serum IL-6 levels. Egger's test revealed a publication bias across the studies for serum and plasma IL-6 levels ( P = 0.00044 and P = 0.01445, respectively). In summary, the meta-analysis and meta-regression confirmed that, compared to healthy controls, individuals with OSAS (children and adults) had higher serum/plasma IL-6 levels.

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Section: Resultsmentioning

confidence: 99%

Evaluation of Serum and Plasma Interleukin-6 Levels in Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

et al. 2020

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“…As a hypoxic disease, it is necessary to consider the hypoxic marker gene Hif‐1α to examine tissue hypoxia (Choi, Merceron, & Mangiavini, 2016). There was also a significant expression of the Hif‐1α gene in the skeletal tissue and condyles of rats with intermittent nasal obstruction, in contrast to the intermittent hypoxia rats (Thorn et al., 2017). This might be ascribed to the fact that the expression of Hif‐1α is a transient effect, so that intermittent hypoxia may only lead to an increase in the expression of the Hif‐1α gene in the hypoxia with a decrease in its expression during the normoxic stage (Nelis, D’Herde, & Goossens, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…This study endeavors to explore the effects of hypoxia and mouth breathing on the condyle of the TMJ at an early stage in rats which might offer a preliminarily answer to the existing uncertainty at the animal level. In previous studies, two animal models have been used in researching (Thorn, Knight, & Pastel, 2017; Wang, Sun, & Zhu, 2019). Therefore, to advance our understanding of this issue, it seems prudent to use these two models for analysis and research.…”

Section: Introductionmentioning

confidence: 99%

Mouth breathing impairs the development of temporomandibular joint at a very early stage

Sun

et al. 2020

Oral Diseases

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Objectives The study aimed to explore the effects of mouth breathing and hypoxia on the condyle of temporomandibular joint (TMJ) via two animal models. Methods 24 four‐week‐old rats were randomly separated into three groups, consisting of eight control rats, eight intermittent hypoxia (IH) rats, and eight intermittent nasal obstruction (INO) rats. We use the IH model and the INO model to simulate children suffering from hypoxia and mouth breathing. After 16 days, the condyle of TMJ and surrounding white adipose tissue (WAT) and skeletal muscle tissue were obtained for further staining and qRT‐PCR. Finally, RNA‐seq was used to verify the results. Results The intermittent hypoxia cannot significantly change the overall structure in the cause of short‐term hypoxia stimulation, but the intermittent nasal obstruction can alter the condyle, WAT, and muscle, while also introducing noticeable structural changes in tissue hypoxia and macrophage infiltration. Sequencing data verified these findings and also suggested that this process might involve the Hif‐1α/Vegf axis. Conclusions Our findings reveal the very early structural impact of mouth breathing on condyle reconstruction in rat models, and hypoxia does not induce evident alteration on condyle. However, since these results are mainly focused on rats, further studies are needed to understand its effects on humans.

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“…Other reasons also contribute to PRF after surgery in MG patients with high BMI. Hypoxia is a main driver of adipose tissue dysfunction in obesity [ 24 , 25 ], and oxygen tension activates hypoxia inducible factor-1 (HIF-1), a key factor in the response to low oxygenation, which in turn generates a series of inflammatory responses [ 6 , 26 ]. There is no doubt that both hypoxia and systemic inflammation have adverse effects on MG.…”

Section: Discussionmentioning

confidence: 99%

Influence of body mass index on postoperative complications after thymectomy in myasthenia gravis patients

et al. 2017

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ObjectivesIt is not clear whether being overweight or obese influences postoperative complications in myasthenia gravis (MG) patients. We retrospectively investigated an association between body mass index (BMI) and postoperative complications in MG.Materials and MethodsFifty-nine MG patients who had undergone transsternal thymectomy were classified as low or high BMI based on the criteria for Asian-Pacific populations. An association between BMI and complications was analyzed.ResultsMG patients with high BMI had significantly higher rates of major adverse complications (P = 0.033), postoperative respiratory failure (P = 0.045), and longer postoperative hospitalization (P = 0.005). The optimal cutoff value of BMI for postoperative respiratory failure was 23.3 kg/m2, with a sensitivity of 75.0% and a specificity of 64.7% (P = 0.046).ConclusionsMG patients with a BMI indicating overweight or obesity have a higher risk of postoperative complications after thymectomy. Thus, close monitoring must be performed when surgery is necessary.

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Adipose tissue is influenced by hypoxia of obstructive sleep apnea syndrome independent of obesity

Cited by 25 publications

References 44 publications

Evaluation of Serum and Plasma Interleukin-6 Levels in Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

Evaluation of Serum and Plasma Interleukin-6 Levels in Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

Mouth breathing impairs the development of temporomandibular joint at a very early stage

Influence of body mass index on postoperative complications after thymectomy in myasthenia gravis patients

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