Adipose tissue inflammation in breast cancer survivors: effects of a 16-week combined aerobic and resistance exercise training intervention

Dieli-Conwright, Christina M.; Parmentier, Jean-Hugues; Sami, Nathalie; Lee, Kyuwan; Spicer, Darcy; Mack, Wendy J.; Sattler, Fred R.; Mittelman, Steven D.

doi:10.1007/s10549-017-4576-y

Cited by 84 publications

(129 citation statements)

References 31 publications

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“…On the other hand, exercise inhibits inflammation in adipose tissue and creates unfavorable conditions for cancer, (Dieli‐Conwright et al. ) a reduction in breast cancer incidence and improved survival (McTiernan et al. ; Moore et al.…”

Section: Discussionmentioning

confidence: 99%

Determinants of exercise intolerance in breast cancer patients prior to anthracycline chemotherapy

et al. 2019

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Women with early‐stage breast cancer have reduced peak exercise oxygen uptake (peak VO2). The purpose of this study was to evaluate peak VO2 and right (RV) and left (LV) ventricular function prior to adjuvant chemotherapy. Twenty‐nine early‐stage breast cancer patients (mean age: 48 years) and 10 age‐matched healthy women were studied. Participants performed an upright cycle exercise test with expired gas analysis to measure peak VO2. RV and LV volumes and function were measured at rest, submaximal and peak supine cycle exercise using cardiac magnetic resonance imaging. Peak VO2 was significantly lower in breast cancer patients versus controls (1.7 ± 0.4 vs. 2.3 ± 0.5 L/min, P = 0.0013; 25 ± 6 vs. 35 ± 6 mL/kg/min, P = 0.00009). No significant difference was found between groups for peak upright exercise heart rate (174 ± 13 vs. 169 ± 16 bpm, P = 0.39). Rest, submaximal and peak exercise RV and LV end‐diastolic and end‐systolic volume index, stroke index, and cardiac index were significantly lower in breast cancer patients versus controls (P < 0.05 for all). No significant difference was found between groups for rest and exercise RV and LV ejection fraction. Despite preserved RV and LV ejection fraction, the decreased peak VO2 in early‐stage breast cancer patients prior to adjuvant chemotherapy is due in part to decreased peak cardiac index secondary to reductions in RV and LV end‐diastolic volumes.

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Section: Discussionmentioning

confidence: 99%

Determinants of exercise intolerance in breast cancer patients prior to anthracycline chemotherapy

et al. 2019

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“…Inflammatory biomarkers and adipose tissue were examined at baseline and at end of intervention and also showed significant improvement in markers of inflammation with exercise. 45 …”

Section: Intervention Studies On Body Composition Among Breast Cancermentioning

confidence: 99%

Clinical implications of low skeletal muscle mass in early-stage breast and colorectal cancer

Feliciano

Chen

2018

Proc. Nutr. Soc.

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Although obesity has now been widely accepted to be an important risk factor for cancer survival, the associations between body mass index and cancer mortality have not been consistently linear. Although morbid obesity has clearly been associated with worse survival, some studies have suggested a U-shaped association with no adverse association with overweight or lower levels of obesity. This “obesity paradox” may be due to the fact that body mass index likely incompletely captures key measures of body composition, including distribution of skeletal muscle and adipose tissue. Fat and lean body mass can be measured using clinically acquired CT scans. Many of the earlier studies focused on patients with metastatic cancer. However, skeletal muscle loss in the metastatic setting may reflect end stage disease processes. Therefore, this article focuses on the clinical implication of low skeletal muscle mass in early stage non-metastatic breast and colorectal cancer where measures of body composition have been shown to be strong predictors of disease-free survival and overall survival and also chemotherapy toxicity and operative risk.

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“…Numerous authors agree in the effects of physical exercise on the AT [ 18 , 19 , 20 , 21 ], such as changes in the AT phenotype that lead to a significant decrease of M1 macrophages and an increase of M2 macrophages, as well as the secretion of more anti-inflammatory cytokines, such as IL-6 and TNF-α [ 22 ]. Other researchers have studied the possible changes in the signaling pathways after implementing exercise programs, reporting a decrease of postprandial lipemia, a reduction in NF-kB signaling, and an increase in AMPK signaling (showing anti-inflammatory properties) [ 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Changes in Lipoinflammation Markers in People with Obesity after a Concurrent Training Program: A Comparison between Men and Women

González-Jurado

Suárez-Carmona

López

et al. 2020

IJERPH

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Obesity is related to low-grade systemic inflammation. This state of inflammation is characterized by the alteration in adipokine regulation, which may lead to a situation of cardiometabolic risk. The aim of this study was to evaluate the effects of a concurrent training program on markers of lipoinflammation in adult people with obesity, comparing the response to the training between men and women. A quasi-experimental, quantitative, and longitudinal study with a pre–post intervention was conducted. An 8-week concurrent training program was carried out, in which 26 individuals with obesity participated (mean ± SD; age = 46.38 ± 4.66) (BMI = 36.05 ± 4.99) (12 men and 14 women). Before and after the intervention period, blood samples were taken by percutaneous puncture. The blood levels of adiponectin and leptin were evaluated. Significant differences were obtained in the adiponectin–leptin ratio (A/L ratio) of the entire sample (p = 0.009, ES = 0.53), which indicates a decrease in the risk of cardiovascular diseases and lipoinflammation. There were no significant differences in the improvements observed after the training in A/L ratio between women (A/L change = +63.5%) and men (A/L change= +59.2%). It can be concluded that the combination of aerobic exercise and resistance training induced an improvement in markers of lipoinflammation and cardiometabolic risk in the individuals with obesity evaluated in this study.

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Adipose tissue inflammation in breast cancer survivors: effects of a 16-week combined aerobic and resistance exercise training intervention

Cited by 84 publications

References 31 publications

Determinants of exercise intolerance in breast cancer patients prior to anthracycline chemotherapy

Determinants of exercise intolerance in breast cancer patients prior to anthracycline chemotherapy

Clinical implications of low skeletal muscle mass in early-stage breast and colorectal cancer

Changes in Lipoinflammation Markers in People with Obesity after a Concurrent Training Program: A Comparison between Men and Women

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