Adipose tissue extracellular matrix: newly organized by adipocytes during differentiation

Nakajima, Ikuyo; Yamaguchi, Takahiro; Ozutsumi, Kyouhei; Aso, Hisashi

doi:10.1111/j.1432-0436.1998.00193.x

Cited by 163 publications

(55 citation statements)

References 28 publications

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“…2h) used in this investigation and in accordance with other studies [26]. DAT is a rich source of collagen type I-VI, laminin, fibronectin, and many other bioactive molecules [27][28][29]. Hence, it is expected that by preparing tissue-printed constructs using a DAT bioink, the advantages of the ECM for tissue regeneration can be gained.…”

Section: Decellularization Of Adipose Tissue and Formulation Of Dat Bsupporting

confidence: 61%

Biomimetic 3D tissue printing for soft tissue regeneration

et al. 2015

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Section: Decellularization Of Adipose Tissue and Formulation Of Dat Bsupporting

confidence: 61%

Biomimetic 3D tissue printing for soft tissue regeneration

et al. 2015

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“…Similar alterations have also been described in adipose tissue (Sun, Tordjman, Clement, & Scherer, 2013). Interestingly, undifferentiated adipogenic progenitor cells are a major source of ECM components in AT (Kubo, Kaidzu, Nakajima, Takenouchi, & Nakamura, 2000; Nakajima, Yamaguchi, Ozutsumi, & Aso, 1998), suggesting that alterations in progenitor cell function with increased age may contribute to homeostatic changes in the tissue matrix (Tchkonia et al, 2010). Periostin is a secreted factor and its binding integrin heterodimers has been shown to activate protein kinase B and the focal adhesion kinase‐mediated intracellular signaling (Idolazzi et al, 2017; Kuhn et al, 2007; Morra & Moch, 2011).…”

Section: Discussionmentioning

confidence: 99%

Loss of periostin occurs in aging adipose tissue of mice and its genetic ablation impairs adipose tissue lipid metabolism

et al. 2018

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Remodeling of the extracellular matrix is a key component of the metabolic adaptations of adipose tissue in response to dietary and physiological challenges. Disruption of its integrity is a well‐known aspect of adipose tissue dysfunction, for instance, during aging and obesity. Adipocyte regeneration from a tissue‐resident pool of mesenchymal stem cells is part of normal tissue homeostasis. Among the pathophysiological consequences of adipogenic stem cell aging, characteristic changes in the secretory phenotype, which includes matrix‐modifying proteins, have been described. Here, we show that the expression of the matricellular protein periostin, a component of the extracellular matrix produced and secreted by adipose tissue‐resident interstitial cells, is markedly decreased in aged brown and white adipose tissue depots. Using a mouse model, we demonstrate that the adaptation of adipose tissue to adrenergic stimulation and high‐fat diet feeding is impaired in animals with systemic ablation of the gene encoding for periostin. Our data suggest that loss of periostin attenuates lipid metabolism in adipose tissue, thus recapitulating one aspect of age‐related metabolic dysfunction. In human white adipose tissue, periostin expression showed an unexpected positive correlation with age of study participants. This correlation, however, was no longer evident after adjusting for BMI or plasma lipid and liver function biomarkers. These findings taken together suggest that age‐related alterations of the adipose tissue extracellular matrix may contribute to the development of metabolic disease by negatively affecting nutrient homeostasis.

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“…Indirect immunofluorescence techniques have identified that the outer sheath contains a mixture of types I, III, V and VI collagen along with laminin, proteoglycans and other glycoproteins (Nakajima et al, 1998).…”

Section: Review Of the Anatomy Of Adipose Tissuementioning

confidence: 99%

A micromechanical model for the Young’s modulus of adipose tissue

Comley

Fleck

2010

International Journal of Solids and Structures

174

120

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a b s t r a c tThe microstructure of porcine adipose tissue is examined, and a micromechanical model is proposed for the dependence of overall effective modulus upon the moduli of the constituent microstructural units. Scanning electron microscopy and confocal microscopy reveal that the woven collagen network surrounding each adipocyte resembles a closed cell foam of relative density q m ¼ 0:1, while the collagen interlobular septa behave as an open cell foam of relative density q s ¼ 3 Â 10 À4 . The measured viscosity of the lipid within the adipocytes is g = 36.8 mPa s at 37°C; this is sufficiently small for the lipid to be idealised as an incompressible inviscid fluid. It is argued that the modulus of adipose tissue is dictated by the collagen network that surrounds the adipocytes. The volume fraction of the interlobular septa is sufficiently low that it provides a negligible contribution to the macroscopic modulus.

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Adipose tissue extracellular matrix: newly organized by adipocytes during differentiation

Cited by 163 publications

References 28 publications

Biomimetic 3D tissue printing for soft tissue regeneration

Biomimetic 3D tissue printing for soft tissue regeneration

Loss of periostin occurs in aging adipose tissue of mice and its genetic ablation impairs adipose tissue lipid metabolism

A micromechanical model for the Young’s modulus of adipose tissue

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