Adipose Tissue Exosomal Proteomic Profile Reveals a Role on Placenta Glucose Metabolism in Gestational Diabetes Mellitus

Jayabalan, Nanthini; Lai, Andrew; Ormazábal, Valeska; Adam, Stefanie; Guanzon, Dominic; Palma, Carlos; Scholz-Romero, Katherin; Lim, Ratana; Jansson, Thomas; McIntyre, H. David; Lappas, Martha; Salomón, Carlos

doi:10.1210/jc.2018-01599

Cited by 79 publications

(72 citation statements)

References 74 publications

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“…Recently, Jeyabalan and colleagues demonstrate that treatment with exosomes from adipose tissue (AT) of NGT pregnant women affects the expression of glucose metabolism‐related genes in placental cells. They provide data that the up‐regulated genes in placental cells are associated with glycolysis (HK3 and TPI1), gluconeogenesis (PCK1 and G6PC), glycogen production (UGP2) and degradation (PYGM), suggesting that physiological adaptation by exosomes could satisfy increasing glucose usage in foetus and placenta across pregnancy …”

Section: Evs In Normal Pregnancymentioning

confidence: 99%

“…It is possible that increased placental glycogenolysis in GDM accelerates glucose transferring to foetus, resulting in foetal overgrowth. Furthermore, ingenuity pathway analysis reveals the differential expression of mitochondrial function‐related proteins in AT exosomes of GDM . The work from Nair et al shows that placental exosomes are capable of modulating insulin‐stimulated migration and glucose uptake in primary skeletal muscle cells.…”

Section: Evs In Complicated Pregnancymentioning

confidence: 99%

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Extracellular vesicles in normal pregnancy and pregnancy‐related diseases

Zhang

Fan

et al. 2020

J Cellular Molecular Medi

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Extracellular vesicles (EVs) are nanosized, membranous vesicles released by almost all types of cells. Extracellular vesicles can be classified into distinct subtypes according to their sizes, origins and functions. Extracellular vesicles play important roles in intercellular communication through the transfer of a wide spectrum of bioactive molecules, contributing to the regulation of diverse physiological and pathological processes. Recently, it has been established that EVs mediate foetal-maternal communication across gestation. Abnormal changes in EVs have been reported to be critically involved in pregnancy-related diseases. Moreover, EVs have shown great potential to serve as biomarkers for the diagnosis of pregnancy-related diseases.In this review, we discussed about the roles of EVs in normal pregnancy and how changes in EVs led to complicated pregnancy with an emphasis on their values in predicting and monitoring of pregnancy-related diseases.

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Section: Evs In Normal Pregnancymentioning

confidence: 99%

Section: Evs In Complicated Pregnancymentioning

confidence: 99%

Extracellular vesicles in normal pregnancy and pregnancy‐related diseases

Zhang

Fan

et al. 2020

J Cellular Molecular Medi

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“…In response to various stimuli, EVs could be released by adipocytes as adipokines to modulate endocrine changes in the near or distant cells ( Figure 4). Although it is unclear whether these EVs can genuinely act as specialized cargo or adipokines, previous studies have shown that adipocyte-derived EVs (adipocyte-EVs) did have functional outcomes in regulating metabolic and endocrine organs (Table 1) [34][35][36][37][38]. The first study that identified the role of adipocyte-EVs in insulin resistance was performed in a mice model of obesity [34].…”

Section: Extracellular Vesicles (Evs): Adipocyte-derived Evs In Nafldmentioning

confidence: 99%

“…A study of the obese individuals also confirmed that obese adipocytes-EVs contain various microRNAs, and these microRNAs target genes involved in the inflammatory and fibrotic signaling pathways, including the transforming growth factor-beta (TGF-β) and Wnt/β-catenin signaling [36]. Another example of the adipocyte-EVs that mediate the endocrine effects is the study of women with gestational diabetes mellitus (GDM), in which the adipocyte-EVs isolated from their primary omental adipose tissues were positively correlated with the fetal growth [35]. In these GDM adipocyte-EVs, there was an enrichment of the proteins involved in sirtuin signaling, oxidative phosphorylation, rapamycin signaling pathways, and the upregulation of the genes involved in glycolysis and gluconeogenesis [35].…”

Section: Extracellular Vesicles (Evs): Adipocyte-derived Evs In Nafldmentioning

confidence: 99%

“…Another example of the adipocyte-EVs that mediate the endocrine effects is the study of women with gestational diabetes mellitus (GDM), in which the adipocyte-EVs isolated from their primary omental adipose tissues were positively correlated with the fetal growth [35]. In these GDM adipocyte-EVs, there was an enrichment of the proteins involved in sirtuin signaling, oxidative phosphorylation, rapamycin signaling pathways, and the upregulation of the genes involved in glycolysis and gluconeogenesis [35]. Notably, the co-culture of obesity-derived adipocyte-EVs with the hepatocytes showed that adipocyte-EVs are taken into the hepatocytes and HSCs [37].…”

Section: Extracellular Vesicles (Evs): Adipocyte-derived Evs In Nafldmentioning

confidence: 99%

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Extracellular Vesicles in the Development of the Non-Alcoholic Fatty Liver Disease: An Update

et al. 2020

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Non-alcoholic fatty liver disease (NAFLD) is a broad spectrum of liver damage disease from a simple fatty liver (steatosis) to more severe liver conditions such as non-alcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. Extracellular vesicles (EVs) are a heterogeneous group of small membrane vesicles released by various cells in normal or diseased conditions. The EVs carry bioactive components in their cargos and can mediate the metabolic changes in recipient cells. In the context of NAFLD, EVs derived from adipocytes are implicated in the development of whole-body insulin resistance (IR), the hepatic IR, and fatty liver (steatosis). Excessive fatty acid accumulation is toxic to the hepatocytes, and this lipotoxicity can induce the release of EVs (hepatocyte-EVs), which can mediate the progression of fibrosis via the activation of nearby macrophages and hepatic stellate cells (HSCs). In this review, we summarized the recent findings of adipocyte- and hepatocyte-EVs on NAFLD disease development and progression. We also discussed previous studies on mesenchymal stem cell (MSC) EVs that have garnered attention due to their effects on preventing liver fibrosis and increasing liver regeneration and proliferation.

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Tissue‐derived extracellular vesicles in cancers and non‐cancer diseases: Present and future

Man

Gao

et al. 2021

J of Extracellular Vesicle

109

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Extracellular vesicles (EVs) are lipid‐bilayer membrane structures secreted by most cell types. EVs act as messengers via the horizontal transfer of lipids, proteins, and nucleic acids, and influence various pathophysiological processes in both parent and recipient cells. Compared to EVs obtained from body fluids or cell culture supernatants, EVs isolated directly from tissues possess a number of advantages, including tissue specificity, accurate reflection of tissue microenvironment, etc., thus, attention should be paid to tissue‐derived EVs (Ti‐EVs). Ti‐EVs are present in the interstitium of tissues and play pivotal roles in intercellular communication. Moreover, Ti‐EVs provide an excellent snapshot of interactions among various cell types with a common histological background. Thus, Ti‐EVs may be used to gain insights into the development and progression of diseases. To date, extensive investigations have focused on the role of body fluid‐derived EVs or cell culture‐derived EVs; however, the number of studies on Ti‐EVs remains insufficient. Herein, we summarize the latest advances in Ti‐EVs for cancers and non‐cancer diseases. We propose the future application of Ti‐EVs in basic research and clinical practice. Workflows for Ti‐EV isolation and characterization between cancers and non‐cancer diseases are reviewed and compared. Moreover, we discuss current issues associated with Ti‐EVs and provide potential directions.

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Adipose Tissue Exosomal Proteomic Profile Reveals a Role on Placenta Glucose Metabolism in Gestational Diabetes Mellitus

Cited by 79 publications

References 74 publications

Extracellular vesicles in normal pregnancy and pregnancy‐related diseases

Extracellular vesicles in normal pregnancy and pregnancy‐related diseases

Extracellular Vesicles in the Development of the Non-Alcoholic Fatty Liver Disease: An Update

Tissue‐derived extracellular vesicles in cancers and non‐cancer diseases: Present and future

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