2021
DOI: 10.3389/fendo.2021.681649
|View full text |Cite
|
Sign up to set email alerts
|

Adipose Tissue Epigenetic Profile in Obesity-Related Dysglycemia - A Systematic Review

Abstract: BackgroundObesity is a major risk factor for dysglycemic disorders, including type 2 diabetes (T2D). However, there is wide phenotypic variation in metabolic profiles. Tissue-specific epigenetic modifications could be partially accountable for the observed phenotypic variability.ScopeThe aim of this systematic review was to summarize the available data on epigenetic signatures in human adipose tissue (AT) that characterize overweight or obesity-related insulin resistance (IR) and dysglycemia states and to iden… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
5

Citation Types

4
11
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 14 publications
(15 citation statements)
references
References 178 publications
(266 reference statements)
4
11
0
Order By: Relevance
“…7 Recently, our group identified in a prospective study two differentially methylated positions located in the ZFPM2 and CYP2E1 genes, closely associated with the transition from MHO to MUO state. 8 A recent metaanalysis conducted by Andrade et al (2021) found more than 2000 DMRs in the adipose tissue of individuals with MUO compared to individuals with MHO, as our study reported. 14 There are several genes that overlapped our DMRs, such as FLRT, FRMPD4 PSMD5, NKX or LRRC, suggesting a similar effect in obesity.…”
Section: Discussionsupporting
confidence: 78%
See 1 more Smart Citation
“…7 Recently, our group identified in a prospective study two differentially methylated positions located in the ZFPM2 and CYP2E1 genes, closely associated with the transition from MHO to MUO state. 8 A recent metaanalysis conducted by Andrade et al (2021) found more than 2000 DMRs in the adipose tissue of individuals with MUO compared to individuals with MHO, as our study reported. 14 There are several genes that overlapped our DMRs, such as FLRT, FRMPD4 PSMD5, NKX or LRRC, suggesting a similar effect in obesity.…”
Section: Discussionsupporting
confidence: 78%
“…8 A recent metaanalysis conducted by Andrade et al (2021) found more than 2000 DMRs in the adipose tissue of individuals with MUO compared to individuals with MHO, as our study reported. 14 There are several genes that overlapped our DMRs, such as FLRT, FRMPD4 PSMD5, NKX or LRRC, suggesting a similar effect in obesity. 14,15 However, all of these studies did not provide potential candidates to better predict the pathways implicated in the transition from MHO to MUO.…”
Section: Discussionsupporting
confidence: 78%
“…The protein encoded by DPEP2 has been shown to modulate macrophage inflammation ( 88 ), and is upregulated in subcutaneous white adipose tissue in obese women with type 2 diabetes ( 89 ). The most highly ranked MESA eQTM was cg19103704, which is associated with expression of the proteasome 26S subunit, ATPase 4 ( PSMC4 ), a subunit of perilipin-2 which regulates intracellular lipid metabolism in macrophages, and the fc fragment of IgG binding protein ( FCGBP ), both of which have been associated with obesity ( 90 , 91 ).…”
Section: Discussionmentioning
confidence: 99%
“… 52 More than 2000 differentially methylated regions in adipose tissue of individuals with unhealthy overweight/obesity versus normal‐weight individuals or individuals with metabolically healthy overweight/obesity have been identified. 53 However, the epigenetic evidence for long‐term change of obesity from age 10 to postmenopause is lacking. Future studies can integrate genetic and epigenetic data to elucidate the underlying mechanisms driving early life adiposity.…”
Section: Discussionmentioning
confidence: 99%
“…Epigenetic dysregulation during early development may increase the risk of obesity 52 . More than 2000 differentially methylated regions in adipose tissue of individuals with unhealthy overweight/obesity versus normal‐weight individuals or individuals with metabolically healthy overweight/obesity have been identified 53 . However, the epigenetic evidence for long‐term change of obesity from age 10 to postmenopause is lacking.…”
Section: Discussionmentioning
confidence: 99%