Adipose Tissue-Derived Stromal Cells for Wound Healing

Abstract

Skin as the outer layer covers the body. Wounds can affect this vital organ negatively and disrupt its functions. Wound healing as a biological process is initiated immediately after an injury. This process consists of three stages: inflammation, proliferation, remodeling. Generally, these three stages occur continuously and timely. However, some factors such as infection, obesity and diabetes mellitus can interfere with these stages and impede the normal healing process which results in chronic wounds. Financial burden on both patients and health care systems, negative biologic effect on the patient's general health status and reduction in quality of life are a number of issues which make chronic wounds as a considerable challenge. During recent years, along with advances in the biomedical sciences, various surgical and non-surgical therapeutic methods have been suggested. All of these suggested treatments have their own advantages and disadvantages. Recently, cell-based therapies and regenerative medicine represent promising approaches to wound healing. Accordingly, several types of mesenchymal stem cells have been used in both preclinical and clinical settings for the treatment of wounds. Adipose-derived stromal cells are a cost-effective source of mesenchymal stem cells in wound management which can be easily harvest from adipose tissues through the less invasive processes with high yield rates. In addition, their ability to secrete multiple cytokines and growth factors, and differentiation into skin cells make them an ideal cell type to use in wound treatment. This is a concise overview on the application of adipose-derived stromal cells in wound healing and their role in the treatment of chronic wounds.

The Role of Hypoxic Mesenchymal Stem Cells Conditioned Medium in Increasing Vascular Endothelial Growth Factors (VEGF) Levels and Collagen Synthesis to Accelerate Wound Healing

“…Furthermore, a previous study has reported that HMSCs-CM also have a ability to induce chemotaxis and angiogenesis regarding accelerated tissue regeneration (Quade, et al, 2020). The VEGF is one of the most important proangiogenic mediators in addition fibroblast proliferation associated with collagen synthesis that is an essential to induce wound healing at any stage of healing process (Goodarzi, et al, 2018;Johnson & Wilgus, 2014).…”

Auxiliary role of mesenchymal stem cells as regenerative medicine soldiers to attenuate inflammatory processes of severe acute respiratory infections caused by COVID-19

“…Herein, the great discoveries have highlighted that MSCs as regenerative medicine soldiers have long been regarding, based on their multi-potential differentiation capacity and self-renewal ability along with immunomodulatory potency. (Fitzsimmons et al 2018;Goodarzi et al 2018a, b). For instance, some investigations were shown that there is a higher survival rate in the subjects with H7N9 influenza who received MSC therapies compared to control group (Singh et al 2020).…”

“…bone marrow (BM), adipose tissue (AT), placenta (PL), umbilical cord (UC), etc.) and have high-efficiency expansion potential can be effective through their limitless selfrenewal and multi-potential differentiation ability along with their paracrine mediators' association (Aghayan et al 2014;Heo et al 2016;Goodarzi et al 2018a, b;Leng et al 2020). Hereupon, this review focuses on the auxiliary role of MSCs to reduce inflammatory processes of severe ARIs in Cases.…”

Intraoperative Strategies for Minimal Manipulation of Autologous Adipose Tissue for Cell- and Tissue-Based Therapies: Concise Review

“…The multipotent feature of cSVF can stimulate the production of, and terminally differentiate into cells of the existing niche; moreover, their secretome is enriched with an array of soluble factors that have the capacity to promote neoangiogenesis, cytoprotection, or activation of reparative mechanisms . Clinically, autologous cSVF has been used for many different clinical indications such as to regenerate and repair bone and cartilage in concert with bone grafting , in the treatment of osteoarthritis , and in the management of peripheral vascular disease sequela such as chronic wounds . Cellular SVF has been very effective in the treatment of perianal and recto vaginal fistulas as well as for Crohn's disease , in the treatment for the sequela of radiation injury such as fibrosis, atrophy, retraction, and soft tissue ulceration and to reduce aberrant scar formation .…”