Adipose tissue-derived mesenchymal stem cell transplantation promotes hepatic regeneration after hepatic ischemia-reperfusion and subsequent hepatectomy in rats

Seki, Takashi; Yokoyama, Yukihiro; Nagasaki, Hiroshi; Kokuryo, Toshio; Nagino, Masato

doi:10.1016/j.jss.2012.02.014

Cited by 41 publications

(50 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1 × 10 8 ADSCs can be expanded to 10 g of rat epididymal fat pads or human omental fat pads over five passages [42]. Therefore, in the clinical setting, ADSCs could be considered more profitable than BM-MSCs [17]. …”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration—Systematic Review of the Literature Focused on Experimental Studies in Rodent Models

Papanikolaou

Katselis

Αποστόλου

et al. 2017

Stem Cells International

View full text Add to dashboard Cite

Mesenchymal stem cells (MSCs) are an attractive source for regenerative medicine because they are easily accessible through minimally invasive methods and have the potential to enhance liver regeneration (LG) and improve liver function, following partial hepatectomy (PH) and acute or chronic liver injury. A systematic review of the literature was conducted for articles published up to September 1st, 2016, using the MEDLINE database. The keywords that were used in various combinations were as follows: “Mesenchymal stem cells”, “transplantation”, “stem cells”, “adipose tissue derived stem cells”, “bone marrow-derived stem cells”, “partial hepatectomy”, “acute liver failure”, “chronic liver failure”, “liver fibrosis”, “liver cirrhosis”, “rats”, “mice”, and “liver regeneration”. All introduced keywords were searched for separately in MeSH Database to control relevance and terminological accuracy and validity. A total of 41 articles were identified for potential inclusion and reviewed in detail. After a strict selection process, a total of 28 articles were excluded, leaving 13 articles to form the basis of this systematic review. MSCs transplantation promoted LG and improved liver function. Furthermore, MSCs had the ability to differentiate in hepatocyte-like cells, increase survival, and protect hepatocytes by paracrine mechanisms. MSCs transplantation may provide beneficial effects in the process of LG after PH and acute or chronic liver injury. They may represent a new therapeutic option to treat posthepatectomy acute liver failure.

show abstract

Section: Resultsmentioning

confidence: 99%

“…There is a growing body of published evidence which suggests the role of ADSCs in increasing LG rate, limiting severity of chronic hepatic failure, and increasing survival [17, 23, 24]. ADSCs can differentiate along multiple cell lineage pathways in a reproducible and regulatable manner.…”

Section: Resultsmentioning

confidence: 99%

Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration—Systematic Review of the Literature Focused on Experimental Studies in Rodent Models

Papanikolaou

Katselis

Αποστόλου

et al. 2017

Stem Cells International

View full text Add to dashboard Cite

show abstract

“…The control group had significantly more histology scores (congestion, hepatocellular vacuolation, and necrosis) compared to the HADMSC group (p < 0.001). In rodent models of hepatic IRI, autologous adipose tissue-derived MSCs administration significantly preserved hepatocyte integrity, suppressed inflammatory responses and oxidative stress [3,4,9,10]. However, the effect of xenogeneic administration of HADMSCs on liver regeneration has not been fully studied before.…”

Section: Discussionmentioning

confidence: 99%

Human Adipose-Derived Mesenchymal Stem Cells Promote Liver Regeneration

Saidi

Rajeshkumar²,

Shariftabrizi³

et al. 2015

Journal of Investigative Surgery

View full text Add to dashboard Cite

show abstract

“…To date, many studies have reported improvement in conditions related to ischemic diseases, such as myocardial infarction, ischemic stroke, hepatic ischemia, and ischemic limb, with the transplantation of ADSCs that induce ADSC-initiated local angiogenesis [9][10][11][12]. Furthermore, it has recently been shown that ADSCs have the plasticity to differentiate into both endothelial and smooth muscle cells.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Biotubes with vascular cells component by in vivo incubation using adipose-derived stromal cell-exuding multi-microporous molds

2015

View full text Add to dashboard Cite

Biotubes, prepared using in-body tissue architecture (IBTA) technology, have adequate mechanical properties and excellent biocompatibility for vascular grafts. However, they have thin walls, lack vascular constructing cells, and are composed of subcutaneous connective tissues consisting mainly of collagen and fibroblasts. This study aimed to prepare Biotubes with a vascular-like structure including an endothelial cell lining and a smooth muscle cell by IBTA using adipose-derived vascular stromal cell (ADSCs)-exuding specially designed multiporous tubes (outer diameter 5 mm, length 24 mm, pore size 500 μm, pore number 180, cell number/tube >3.0 × 10(6)). ADSCs were separated from rat subcutaneous fat, suspended in a Matrigel™ solution at 4 °C, and then filled into the tubes. After the tubes were embedded into dorsal subcutaneous pouches of the same rats for 2 weeks, robust Biotubes with a wall thickness of >600 μm were formed surrounding the tubes. The luminal layer of the obtained Biotubes was dominated by the cells positive for an endothelial marker. Almost the entire intima, with a thickness of about 400 μm, was occupied with cells positive for a smooth muscle marker. Both cells were derived from ADSCs. Biotube walls were constructed by fusing ADSC-derived vascular constructing cells exuded from the tubes and fibroblasts and collagen from the surrounding connective tissue. A robust Biotubes with vascular cells component, were formed after only 2 weeks of subcutaneous incubation of ADSCs-exuding multiporous tubes.

show abstract

Adipose tissue-derived mesenchymal stem cell transplantation promotes hepatic regeneration after hepatic ischemia-reperfusion and subsequent hepatectomy in rats

Cited by 41 publications

References 47 publications

Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration—Systematic Review of the Literature Focused on Experimental Studies in Rodent Models

Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration—Systematic Review of the Literature Focused on Experimental Studies in Rodent Models

Human Adipose-Derived Mesenchymal Stem Cells Promote Liver Regeneration

Preparation of Biotubes with vascular cells component by in vivo incubation using adipose-derived stromal cell-exuding multi-microporous molds

Contact Info

Product

Resources

About