Adipose tissue concentrations of persistent organic pollutants and prevalence of type 2 diabetes in adults from Southern Spain

Arrebola, Juan Pedro; Pumarega, José; Gasull, Magda; Fernández, Mariana F.; Martín‐Olmedo, Piedad; Molina-Molina, José-Manuel; Fernández-Rodríguez, María; Porta, Miquel; Olea, Nicolás

doi:10.1016/j.envres.2012.12.001

Cited by 88 publications

(60 citation statements)

References 37 publications

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“…The relationship between the human exposure to other environmental pollutants and total cancer has been assessed in previous epidemiological studies (Blair and Freeman, 2009;Mink et al, 2012). We highlight the positive Spearman correlations observed between all POPs in our study; therefore, the associations found with single chemicals may be surrogates of exposure to other more toxic agents or even to mixtures of POPs with similar physicochemical characteristics (Arrebola et al, 2013b;Brauner et al, 2012b). These correlations were expected because, although some of the studied chemicals have different origins (e.g., agriculture or industry), their similar physicochemical properties mean that they accumulate in the lipophilic fractions of food (Duarte-Davidson and Jones, 1994;Herrera et al, 1996), which is acknowledged to be the main source of exposure in non-occupationally exposed populations (Bosch de Basea et.…”

Section: Discussionsupporting

confidence: 64%

“…Although the multivariable models were adjusted for BMI, it should be taken into account that the majority of the study population (66.3%) was obese/overweight (BMI>25 kg/m 2 ), and that most cancers in our cohort were diagnosed among these individuals (cumulative incidence of 8.3% versus 1.6% in subjects with BMI<25 kg/m 2 ). On the other hand, the BMI was positively correlated with POP levels in the present cohort (Arrebola et al, 2013a;Arrebola et al, 2010;Arrebola et al, 2009) and has even been shown to be an important effect modifier of the association between POPs and diabetes (Arrebola et al, 2013b). Therefore, the potential interaction between POPs and obesity in the promotion of cancer deserves to be studied in depth.…”

Section: Discussionmentioning

confidence: 55%

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Adipose tissue concentrations of persistent organic pollutants and total cancer risk in an adult cohort from Southern Spain: Preliminary data from year 9 of the follow-up

Arrebola

Fernández

Martín‐Olmedo

et al. 2014

Science of The Total Environment

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There is an increasing trend in the incidence of cancer worldwide, and it has been accepted that environmental factors account for an important proportion of the global burden. The present paper reports preliminary findings on the influence of the historical exposure to a group of persistent organic pollutants on total cancer risk, at year 9 in the follow-up of a cohort from Southern Spain.A cohort of 368 participants (median age 51 yrs) was recruited in 2003. Their historical exposure was estimated by analyzing residues of persistent organic pollutants in adipose tissue. Estimation of cancer incidence was based on data from a population-based cancer registry. Statistical analyses were performed using multivariable Cox-regression models.In males, PCB 153 concentrations were positively associated with total cancer risk, with an adjusted hazard ratio (95% confidence interval) of 1.20 (1.01-1.41) for an increment of 100 ng/g lipid.Our preliminary findings suggest a potential relationship between the historical exposure to persistent organic pollutants and the risk of cancer in men. However, these results should be interpreted with caution and require verification during the future follow-up of this cohort.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 55%

Adipose tissue concentrations of persistent organic pollutants and total cancer risk in an adult cohort from Southern Spain: Preliminary data from year 9 of the follow-up

Arrebola

Fernández

Martín‐Olmedo

et al. 2014

Science of The Total Environment

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“…18,31 To date, a particularly strong evidence has been accumulated supporting POPs as a risk factor for type 2 diabetes mellitus, insulin resistance, and obesity. [32][33][34][35][36] However, prospective population-based studies linking current exposures to different POPs and hypertension are still lacking. Further evidence on the role of certain POP, such as PCB, exposures on the risk of hypertension and CVD is needed.…”

Section: Donat-vargas Et Al Dietary Intake Of Pcbs and Hypertension 715mentioning

confidence: 99%

Association Between Dietary Intake of Polychlorinated Biphenyls and the Incidence of Hypertension in a Spanish Cohort

et al. 2015

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Polychlorinated biphenyls are persistent organic pollutants that are consumed because of their bioaccumulation through the food chain. Evidence from different sources suggests a positive association between polychlorinated biphenyls exposure and the incidence of hypertension. However, no previous prospective study has investigated this potential relationship in adults. We prospectively assessed the association between dietary intake of polychlorinated biphenyls and the incidence of hypertension in a large cohort. The Seguimiento Universidad de Navarra project is a Spanish cohort of university graduates, most of them health professionals. We included 14521 participants, initially free of hypertension, who were followed-up for a median of 8.3 years. Dietary intake of polychlorinated biphenyls was assessed at baseline through a previously validated 136-item semiquantitative food frequency questionnaire. The published concentration levels of polychlorinated biphenyls measured in samples of food consumed in Spain were used to estimate dietary intake. Multivariable Cox regression models were fitted to estimate hazard ratios and 95% confidence interval for incident hypertension. During follow-up, 1497 incident cases of medically diagnosed hypertension were identified. After adjusting for total energy intake and for potential confounders, participants in the fifth quintile of total polychlorinated biphenyls intake were at higher risk of developing hypertension (adjusted hazard ratio, 1.43 [95% confidence interval, 1.09–1.88; P for trend 0.017]) compared with those in the first quintile. In this Mediterranean cohort, dietary intake of polychlorinated biphenyls, estimated using a food frequency questionnaire, was associated with a higher risk of developing hypertension during follow-up. Nevertheless, further longitudinal studies are needed to confirm our results.

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“…Several cross-sectional studies have disclosed the association of POPs with T2D (Lee et al, 2006 ;Taylor et al, 2013 ;Airaksinen, Rantakokko, Eriksson, Blomstedt, & Kajantie, 2011;Mostafalou, 2016). Some limited prospective studies have also shown that POPs increased the risk of T2D (Arrebola, Pumarega, Gasull, Fernandez, & Martin-Olmedo, 2013;Rignell-Hydbom, Lidfeldt, Kiviranta, Rantakokko, & Samsioe, 2009;Turyk, Anderson, Knobeloch, Imm, & Persky, 2009), but the association between p,p'-DDE and T2D has not been specifically studied. In certain studies, p,p'-DDE is related to T2D (Airaksinen et al, 2011;Hectors, Vanparys, Van Der Ven, Martens, & Jorens, 2011) and there is not a significant association in certain studies (Wang, Tsai, Yang, & Guo, 2008).…”

Section: Introductionmentioning

confidence: 99%

Association between Dichlorodiphenyldichloroethylene in the Serum and Adipose Tissue with Type 2 Diabetes: A Systematic Review and Meta-Analysis

Fakhri¹,

Sheikhmohammadi²,

Bay³

et al. 2016

GJHS

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The number of diabetics is growing every day. In addition to the main risk factors of type 2 diabetes (obesity, age and etc.) other environmental risk factors such as persistent organic pollutants are also considered. Dichlorodiphenyldichloroethylene is one of the persistent organic pollutants which are produced by the pesticide DDT metabolized and its effects of type 2 diabetes are taken into consideration of many investigators. Inconsistency in the results caused to try to achieve a detailed assessment of the effect of dichlorodiphenyldichloroethylene on type 2 diabetes by systematic review and meta-analysis. In this review study after a systematic review, finally 6 prospective and 7 cross-sectional studies were obtained. After approving the heterogeneity of the studies based on random effect model, it was calculate the mean of odds ratio. Meta-analysis of the pooled random effects of Dichlorodiphenyldichloroethylene was done with type 2 diabetes in prospective and cross-sectional studies. In prospective studies, the highest and lowest odds ratio was 6.1 (95%CI: 1.36-27.27) and 1.01 (95%CI: 0.59-1.70) and cross-sectional studies was 5.5 (95%CI: 1.2-25.10) and 0.61 (95%CI: 0.32-1.15), respectively. In the all studies (sum of prospective and cross-sectional), in the random effect model odds ratio was 1.52 (95%CI: 1.26-1.84) and heterogeneity was 52.1% (ρ heterogeneity =0.009). Increasing concentration of Dichlorodiphenyldichloroethylene in the serum and adipose tissue increased the risk of type 2 diabetes significantly (P<0.001). The results of this review study support the role of dichlorodiphenyldichloroethylene as an environmental risk factor for type 2 diabetes.

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Adipose tissue concentrations of persistent organic pollutants and prevalence of type 2 diabetes in adults from Southern Spain

Cited by 88 publications

References 37 publications

Adipose tissue concentrations of persistent organic pollutants and total cancer risk in an adult cohort from Southern Spain: Preliminary data from year 9 of the follow-up

Adipose tissue concentrations of persistent organic pollutants and total cancer risk in an adult cohort from Southern Spain: Preliminary data from year 9 of the follow-up

Association Between Dietary Intake of Polychlorinated Biphenyls and the Incidence of Hypertension in a Spanish Cohort

Association between Dichlorodiphenyldichloroethylene in the Serum and Adipose Tissue with Type 2 Diabetes: A Systematic Review and Meta-Analysis

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