Adipose tissue chromium and vanadium disbalance in high-fat fed Wistar rats

Tinkov, Alexey A.; Popova, Elizaveta V.; Polyakova, Valentina S.; Kwan, Olga V.; Skalny, Anatoly V.; Nikonorov, Alexandr А.

doi:10.1016/j.jtemb.2014.07.006

Cited by 30 publications

(25 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Clinical data are more contradictory indicating an increase [39], decrease [40], or the absence of changes [41] in blood Cu levels in obese individuals. Decreased adipose tissue Cr and V content are in agreement with our previous observation also indicating a significant association between high-fat induced decrease in adipose tissue Cr and V content and metabolic parameters in rats with excessive adiposity [21]. Taking into account the role of chromium [42] and vanadium [43] in insulin signaling, we have also supposed that a decrease in Cr and V levels in adipocytes may at least partially mediate obesity-related insulin resistance [44].…”

Section: Discussionsupporting

confidence: 92%

“…In particular, trace elements like Cr, Zn, V, and Se are considered to be the key elements in glucometabolic disorders due to their insulinmimetic and antioxidant effect [10]. Moreover, numerous studies also demonstrated alteration of iron homeostasis in obesity [11,12] Multiple clinical [13][14][15][16][17] and experimental [18][19][20][21][22] studies demonstrated a tight interplay between trace element balance and obesity-related disorders. At the same time, the majority of experimental data are based on dietary intervention in adult animals, whereas data on the influence of dietary regimen on trace element status in early age are insufficient.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Early High-Fat Feeding Induces Alteration of Trace Element Content in Tissues of Juvenile Male Wistar Rats

Tinkov

Gatiatulina

Popova

et al. 2016

Biol Trace Elem Res

Self Cite

View full text Add to dashboard Cite

The primary objective of the current study was to assess the influence of early high-fat feeding on tissue trace element content in young male Wistar rats. Twenty weanling male Wistar rats were divided into two groups fed standard (STD) or high-fat diet (HFD) containing 10 and 31.6 % of total calories from fat, respectively, for 1 month. Serum lipid spectrum, apolipoproteins, glucose, insulin, adiponectin, and leptin levels were assessed. The level of trace elements was estimated using inductively coupled plasma mass spectrometry. High-fat feeding significantly increased epidydimal (EDAT) and retroperitoneal adipose tissue (RPAT), as well as total adipose tissue mass by 34, 103, and 59 %, respectively. Serum leptin levels in HFD animals were twofold higher than those in the control rats. No significant difference in serum lipid spectrum, apolipoproteins, glucose, adiponectin, and insulin was detected between the groups. HFD significantly altered tissue trace element content. In particular, HFD-fed animals were characterized by significantly lower levels of Cu, I, Mn, Se, and Zn in the liver; Cr, V, Co, Cu, Fe, and I content of EDAT; Co, Cu, I, Cr, V, Fe, and Zn concentration in RPAT samples. At the same time, only serum Cu was significantly depressed in HFD-fed animals as compared to the control ones. Hair Co, Mn, Si, and V levels were significantly increased in comparison to the control values, whereas Se and I content was decreased. HFD feeding induced excessive adiposity and altered tissue trace element content in rats without insulin resistance, adiponectin deficiency, and proatherogenic state. Hypothetically, trace element disbalance may precede obesity-associated metabolic disturbances.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Early High-Fat Feeding Induces Alteration of Trace Element Content in Tissues of Juvenile Male Wistar Rats

Tinkov

Gatiatulina

Popova

et al. 2016

Biol Trace Elem Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…In particular, it has been demonstrated that adipose tissue incorporates vanadium compounds upon supplementation [63]. Chemical analysis revealed that vanadium content in intact adipose tissue and vanadium-enriched adipocytes is 0.21 ± 0.08 [64] and 0.39 ± 0.03 lg/g [65], respectively. It is notable that liver concentration of vanadium varies from undetectable levels in intact animals [66], 0.46-1.45 lg/g in mice treated with various chelating agents [67], to 5.3 ± 0.3 lg/g in KKAy mice treated with bis(allixinato)oxovanadium(IV) complex [68].…”

Section: Testing the Hypothesismentioning

confidence: 99%

Alteration of local adipose tissue trace element homeostasis as a possible mechanism of obesity-related insulin resistance

et al. 2015

Self Cite

View full text Add to dashboard Cite

“…In particular, we have shown that dietary obesity is associated with impaired adipose tissue chromium and vanadium content in laboratory rodents. Moreover, metal concentration in fat pads is tightly associated with metabolic parameters in animals (Tinkov et al, 2015b). Limited data on adipose tissue zinc content in obesity exist.…”

Section: Introductionmentioning

confidence: 99%

Decreased adipose tissue zinc content is associated with metabolic parameters in high fat fed Wistar rats

Tinkov

Popova

Gatiatulina

et al. 2016

Acta Sci Pol Technol Aliment

Self Cite

View full text Add to dashboard Cite

Background. Limited data on adipose tissue zinc content in obesity exist. At the same time, the association between adipose tissue zinc content and metabolic parameters in dietary-induced obesity is poorly studied. Therefore, the primary objective of this study is to assess adipose tissue zinc content and its association with morphometric parameters, adipokine spectrum, proinfl ammatory cytokines, and apolipoprotein profi le in high fat fed Wistar rats. Material and methods. A total of 48 adult female Wistar rats were used in the present study. Rats were fed either control (10% of fat) or high fat diet (31.6% of fat). Adipose tissue zinc content was assessed using inductively coupled plasma mass spectrometry. Rats' serum was examined for adiponectin, leptin, insulin, interleukin-6, and tumor necrosis factor-α using enzyme-linked immunosorbent assay kits. Serum glucose and apolipoprotein spectrum were also evaluated. Results. High fat feeding resulted in a signifi cant 34% decrease in adipose tissue zinc content in comparison to the control values. Fat pad zinc levels were signifi cantly inversely associated with morphometric parameters, circulating leptin, insulin, tumor necrosis factor-α levels and HOMA-IR values. At the same time, a signifi cant correlation with apolipoprotein A1 concentration was observed. Conclusion. Generally, the obtained data indicate that (1) high fat feeding results in decreased adipose tissue zinc content; (2) adipose tissue zinc content is tightly associated with excessive adiposity, infl ammation, insulin resistance and potentially atherogenic changes.

show abstract

Adipose tissue chromium and vanadium disbalance in high-fat fed Wistar rats

Cited by 30 publications

References 52 publications

Early High-Fat Feeding Induces Alteration of Trace Element Content in Tissues of Juvenile Male Wistar Rats

Early High-Fat Feeding Induces Alteration of Trace Element Content in Tissues of Juvenile Male Wistar Rats

Alteration of local adipose tissue trace element homeostasis as a possible mechanism of obesity-related insulin resistance

Decreased adipose tissue zinc content is associated with metabolic parameters in high fat fed Wistar rats

Contact Info

Product

Resources

About