Adipose tissue aging: mechanisms and therapeutic implications

Ou, Min-Yi; Zhang, Hao; Tan, Poh-Ching; Zhou, Shuang-Bai; Li, Qing-Feng

doi:10.1038/s41419-022-04752-6

Cited by 105 publications

(103 citation statements)

References 152 publications

(164 reference statements)

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“…Age-related muscle mass loss results in a decrease in basal metabolic rate, which may increase fat mass. Fat tissue is an active endocrine organ, producing hormones and cytokines involved in systemic inflammation, oxidative stress, mitochondrial dysfunction, and insulin resistance [ 2 , 8 , 9 ]. An ectopic fatty infiltration of skeletal muscles, known as miosteatosis, reduces the effectiveness of muscular contraction and impairs muscle strength [ 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Sarcopenia, Obesity, Sarcopenic Obesity and Risk of Poor Nutritional Status in Polish Community-Dwelling Older People Aged 60 Years and Over

Murawiak

Krzymińska‐Siemaszko

Kaluźniak-Szymanowska

et al. 2022

Nutrients

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Poor nutritional status (PNS) is a modifiable factor determining abnormalities in body composition-sarcopenia, obesity, and sarcopenic obesity (SO). We aimed to assess the prevalence of these conditions and their association with PNS in 211 community-dwelling older adults. Sarcopenia was diagnosed based on the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) recommendations. Obesity was diagnosed with the Percent Body Fat (>42% in women and >30% in men). Subjects fulfilling the criteria for obesity and concomitantly with reduced lower and/or upper limbs muscle strength and muscle mass (ALM/BMI < 0.512 in women and <0.789 in men) were classified as SO phenotype. Participants without obesity and sarcopenia were categorized as ‘normal’ phenotype. Nutritional status was estimated with the Mini Nutritional Assessment, and a score of <24 indicated PNS. In total, 49.8% participants had abnormal body composition (60.7% men and 42.5% women; p = 0.001). Sarcopenia, obesity, and SO were diagnosed in 10%, 32.7%, and 7.1% of subjects. PNS was found in 31.3% of the study sample. Its prevalence differed between phenotypes: 81% in sarcopenia, 60% in SO, 14.5% in obesity, and 28.3% in the ‘normal’ phenotype group (p = 0.000). Based on the results, abnormal body composition is prevalent in elderly subjects. Sarcopenia and SO are often associated with PNS.

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Section: Introductionmentioning

confidence: 99%

Sarcopenia, Obesity, Sarcopenic Obesity and Risk of Poor Nutritional Status in Polish Community-Dwelling Older People Aged 60 Years and Over

Murawiak

Krzymińska‐Siemaszko

Kaluźniak-Szymanowska

et al. 2022

Nutrients

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“…The latter features are viewed as an age-related ‘whitening’ of thermogenic adipose tissue and are consistent with the reduction in nonshivering thermogenesis ( McDonald et al, 1988 ; Scarpace et al, 1992 ; Florez-Duquet and McDonald, 1998 ; McDonald and Horwitz, 1999 ; Saito et al, 2009 ) and increased risk of cold-induced hypothermia with aging ( Florez-Duquet and McDonald, 1998 ). The age-associated changes in thermogenic adipose tissue may also be mechanistically linked to the increase in the age-associated risk of metabolic diseases ( Ou et al, 2022 ).…”

Section: Thermogenic Adipose Tissue Changes In Agingmentioning

confidence: 99%

“…Inflammation and adipose tissue dysfunction are closely linked in a vicious cycle and negatively affect the risk of metabolic diseases ( Kawai et al, 2021 ). Both processes are observed during aging, and the effect of many immune cells and products involved in adipose tissue inflammation with aging has been characterized ( Ou et al, 2022 ). Emerging evidence indicates that this relation also affects thermogenic adipocytes and can play a role in diminished age-related nonshivering thermogenesis.…”

Section: Mechanisms Of Thermogenic Adipose Tissue Decline With Agingmentioning

confidence: 99%

“…Overall changes in adipose tissue mass, distribution, and function with aging have a significant impact on other tissues, given the widespread crosstalk between adipose tissue and other tissues through several pathways, including those involving metabolic fuels, endocrine factors affecting insulin sensitivity, the inflammatory response, and circulating miRNAs ( Ou et al, 2022 ).…”

Section: Implications Of Thermogenic Adipocyte Loss With Agingmentioning

confidence: 99%

“…It is well-acknowledged that brown and beige adipocytes’ diminished mass and activity impairs the response to cold and increases the risk of cold-induced hypothermia in the elderly. Moreover, decreased energy expenditure may contribute to reduced energy consumption in the elderly ( Ou et al, 2022 ).…”

Section: Implications Of Thermogenic Adipocyte Loss With Agingmentioning

confidence: 99%

See 2 more Smart Citations

Thermogenic adipose tissue aging: Mechanisms and implications

Silva

Amato

2022

Front. Cell Dev. Biol.

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Adipose tissue undergoes significant anatomical and functional changes with aging, leading to an increased risk of metabolic diseases. Age-related changes in adipose tissue include overall defective adipogenesis, dysfunctional adipokine secretion, inflammation, and impaired ability to produce heat by nonshivering thermogenesis. Thermogenesis in adipose tissue is accomplished by brown and beige adipocytes, which also play a role in regulating energy homeostasis. Brown adipocytes develop prenatally, are found in dedicated depots, and involute in early infancy in humans. In contrast, beige adipocytes arise postnatally in white adipose tissue and persist throughout life, despite being lost with aging. In recent years, there have been significant advances in the understanding of age-related reduction in thermogenic adipocyte mass and function. Mechanisms underlying such changes are beginning to be delineated. They comprise diminished adipose precursor cell pool size and adipogenic potential, mitochondrial dysfunction, decreased sympathetic signaling, and altered paracrine and endocrine signals. This review presents current evidence from animal models and human studies for the mechanisms underlying thermogenic adipocyte loss and discusses potential strategies targeting brown and beige adipocytes to increase health span and longevity.

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Comprehensive Matrisome Profiling of Human Adipose Tissue for Soft Tissue Reconstruction

Major,

Simcock,

Kumar

et al. 2023

Advanced Biology

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For effective translation of research from tissue engineering and regenerative medicine domains, the cell‐instructive extracellular matrix (ECM) of specific tissues must be accurately realized. As adipose tissue is gaining traction as a biomaterial for soft tissue reconstruction, with highly variable clinical outcomes obtained, a quantitative investigation of the adipose tissue matrisome is overdue. In this study, the human adipose tissue matrisome is profiled using quantitative sequential windowed acquisition of all theoretical fragment ion spectra ‐ mass spectrometry (SWATH‐MS) proteomics across a cohort of 13 fat‐grafting patients, to provide characterization of ECM proteins within the tissue, and to understand human population variation. There are considerable differences in the expression of matrisome proteins across the patient cohort, with age and lipoaspirate collection technique contributing to the greatest variation across the core matrisome. A high abundance of basement membrane proteins (collagen IV and heparan sulfate proteoglycan) is detected, as well as fibrillar collagens I and II, reflecting the hierarchical structure of the tissue. This study provides a comprehensive proteomic evaluation of the adipose tissue matrisome and contributes to an enhanced understanding of the influence of the matrisome in adipose‐related pathologies by providing a healthy reference cohort and details an experimental pipeline that can be further exploited for future biomaterial development.

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Adipose tissue aging: mechanisms and therapeutic implications

Cited by 105 publications

References 152 publications

Sarcopenia, Obesity, Sarcopenic Obesity and Risk of Poor Nutritional Status in Polish Community-Dwelling Older People Aged 60 Years and Over

Sarcopenia, Obesity, Sarcopenic Obesity and Risk of Poor Nutritional Status in Polish Community-Dwelling Older People Aged 60 Years and Over

Thermogenic adipose tissue aging: Mechanisms and implications

Comprehensive Matrisome Profiling of Human Adipose Tissue for Soft Tissue Reconstruction

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