Adipose Tissue Abnormalities in Cystic Fibrosis: Noninvasive Determination of Mono- and Polyunsaturated Fatty Acids by Carbon-13 Topical Magnetic Resonance Spectroscopy

Rj, Dimand; Ct, Moonen; Sc, Chu; Em, Bradbury; Kurland, Geoffrey; Kl, Cox

doi:10.1203/00006450-198808000-00021

Cited by 23 publications

(22 citation statements)

References 22 publications

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“…In patients with Crohn's disease, resection length was associated with the composition of fatty acids in the adipose tissue, and increased proportions of unsaturated fatty acids were found; but the authors attribute this to an increased demand for precursors or local prostaglandin synthesis, rather than to disease activity (67). In cystic fibrosis, on the other hand, where there is a malabsorption of fat, an expected reduction in polyunsaturated and monounsaturated fatty acids is seen, as compared to normal volunteers (68). All told, there appears to be little cause for concern that disease states are directly affecting the adipose tissue composition.…”

Section: Raementioning

confidence: 97%

Adipose Tissue as a Medium for Epidemiologic Exposure Assessment

Kohlmeier¹,

Kohlmeier²

1995

Environmental Health Perspectives

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In the United States, adipose tissue is rarely used as a medium for assessment of prior exposures in epidemiologic studies. Adipose tissue aspirations are in general less invasive and carry less risk than phlebotomy. Tissue samples can be analyzed for a wide number of epidemiologically important exposures. Beyond reflecting long-term energy balance, this tissue offers a relatively stable depot of triglyceride and fat-soluble substances, such as fat-soluble vitamins, and pesticides. As a tissue it represents the greatest reservoir of carotenoids in the body. Halogenated hydrocarbons may be measured in concentrations of hundreds-fold greater than those in blood of the same individuals. The composition of adipose tissue also reflects the long-term dietary intakes of a number of essential fatty acids. The turnover times of all of these substances in adipose tissue remain under-researched. Sampling and storage of adipose tissue, homogeneity of sampling sites, turnover times, and the effects of diet, age, gender, race, hormones, and disease on adipose tissue composition are discussed in this review of current knowledge about adipose tissue stability. Experience in the use of adipose tissue sampling in epidemiologic studies in various countries has shown that it is simple to conduct, requires little training, carries little risk, and does not result in excessive participant refusal. -Environ Health Perspect 103(Suppl 3): 99-106 (1995)

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Section: Raementioning

confidence: 97%

Adipose Tissue as a Medium for Epidemiologic Exposure Assessment

Kohlmeier¹,

Kohlmeier²

1995

Environmental Health Perspectives

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“…2 the signals pattern indicates the presence of only two major lipid classes: triacylglycerols (TAG) and wax esters (WE). The assignment of these signals, reported in Table 1, was made on the basis of previous studies on vegetable oils, fish lipids, and intact adipose tissues (Gunstone, 1993;Aursand et al, 1993;Dimand et al, 1973).…”

Section: Nmr Qualitative Analysismentioning

confidence: 99%

A histological and NMR study of the melon of the striped dolphin (Stenella coeruleoalba)

Scano

Maxia

Maggiani

et al. 2005

Chemistry and Physics of Lipids

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“…There have also been several applications of 13 C-MRS to diseases such as cystic fibrosis, where reduced levels of adipose polyunsaturated fatty acids have been reported 7,11 . Interestingly despite GLC of adipose tissue samples revealing significant reductions in omega-3 FAs between malnourished patients prior to liver transplantation, no significant differences were found by 13 C MRS of adipose tissue 12 .…”

Section: <Figure 1 Near Here> <Table 1 Near Here>mentioning

confidence: 99%

Body Fat MRS

Thomas

Bell

2015

eMagRes

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Dr E Louise Thomas obtained her PhD in vivo 13 C MRS from the University of London in 1996. She worked for many years at the Robert Steiner MRI Unit at the Hammersmith Hospital on the development and application of in vivo MR techniques to the study of adipose tissue composition, content and distribution. She has also worked extensively on the non-invasive study of ectopic fat, particularly liver fat and has published over 80 peerreviewed articles in this area. She has recently been appointed as a Senior Lecturer at the University of Westminster.Professor Jimmy D Bell completed his PhD in Biochemistry in 1987 (London). He has worked extensively on the development and application of in vivo MR techniques for the study of disease development, with especial focus on adipose tissue and liver metabolism. He joined the MRC Clinical Sciences Centre (Imperial College London) in the mid-1990s, where he was appointed Group Head. He recently moved to the University of Westminster to establish a new Research Centre for Optimal Health (ReCOH). He has published over 190 peer-reviewed papers and authored over a dozen chapters for scientific books.Keywords: body fat, adipose tissue, magnetic resonance imaging, magnetic resonance spectroscopy; bone marrow; visceral; subcutaneous; 2 AbstractThe increasing levels of obesity, and its associated co-morbidities, have prompted a reassessment of the techniques used for assessing body fat, including content, distribution and composition. Magnetic resonance spectroscopy (MRS) is amongst the many invaluable in vivo tools available today to evaluate the role of body fat in health and disease. However, although MRS has become a powerful technique for assessing ectopic fat in vivo, it has had limited use in other areas of research associated with body fat. MRS has found some success as a fast method to determine whole body adiposity in rodent models of disease, as well as a noninvasive method of obtaining an index of the overall composition of body fat in human subjects. Its more significant use has been in the understanding of bone marrow fat content, where important advances have been made, especially in longitudinal studies. In conclusion, in the area of body fat, MRS continues to be an adjunct technique to more precise and versatile MRI methods.

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Adipose Tissue Abnormalities in Cystic Fibrosis: Noninvasive Determination of Mono- and Polyunsaturated Fatty Acids by Carbon-13 Topical Magnetic Resonance Spectroscopy

Cited by 23 publications

References 22 publications

Adipose Tissue as a Medium for Epidemiologic Exposure Assessment

Adipose Tissue as a Medium for Epidemiologic Exposure Assessment

A histological and NMR study of the melon of the striped dolphin (Stenella coeruleoalba)

Body Fat MRS

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