Adipose‐related microRNAs as modulators of the cardiovascular system: the role of epicardial adipose tissue

Santos, Diana; Carvalho, Eugénia

doi:10.1113/jp280917

Cited by 13 publications

(10 citation statements)

References 93 publications

(215 reference statements)

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“…Vitro studies in rat cardiomyocytes have found that increased expression of miR-208a secreted by EAT could damage mitochondrial β-oxidation, thereby changing the contractile function of the myocardium [ 37 ] through the renin-angiotensin-aldosterone system. Tran et al discovered that the increase of miR-155 and miR-302a-3p in the plasma of patients with atrial fibrillation was positively correlated with the thickness of EAT, which may be related to heart remodeling [ 38 , 39 ]. An increase in the volume of TNF-α secreted by EAT could induce changes in cardiomyocyte apoptosis, cardiac dilatation, and extracellular matrix remodeling [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Correlation analysis of epicardial adipose tissue and ventricular myocardial strain in Chinese amateur marathoners using cardiac magnetic resonance

Wang

Song

et al. 2022

PLoS ONE

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Background The volume of epicardial adipose tissue (EAT) is associated with an increased incidence of cardiovascular disease (CVD); however, only a few studies have examined its effect on the myocardial function of endurance in athletes. The association between the EAT and the variation of myocardial function is still unclear in amateur marathoners. Consequently, by using some sedentary individuals as the control, this study aims to evaluate the correlation between the EAT volume and the myocardial strain in the left and right ventricles of Chinese amateur marathoners by cardiac magnetic resonance (CMR). Methods A total of 30 amateur marathoners were included as the exercise group and 20 sedentary people as a control group. All participants received the cardiac magnetic resonance (CMR) to measure the left and right ventricular end-diastolic volume, end-systolic volume and volume index, stroke volume and index, cardiac output index, ejection fraction and myocardial mass, the EAT volume, global radial, circumferential, and longi-tudinal strains, and the strain rates of left and right ventricular myocardium. Results There was a significant difference in the EAT volume (EATV) index between the exercise group and the control group (26.82±11.76ml/m2 vs 37.82±17.15ml/m2, P = 0.01). Results from the multivariate linear regression analysis showed that BMI (standardized β = 0.458; P < 0.001) had an independent positive correlation with the EATV index. The EATV index was negatively correlated with the left ventricular global radial strain (GRS) (r = -0.505; P = 0.004) in the exercise group, while it is negatively correlated with right ventricular GRS (r = -0.492; P = 0.027) and positively correlated with global longitudinal strain (GLS) (r = 0.601; P = 0.005) in the control group. In the exercise group, the multivariate linear regression analysis showed that the EATV index (standardized β = -0.429; P = 0.021) was an independent determinant of the left ventricular GRS, and being a male (standardized β = 0.396; P = 0.029) was an independent determinant of the right ventricular GLS. Conclusion The EATV index is independently correlated with the left ventricular GRS in the amateur Chinese marathoners, also, the amateur marathon reduces the EATV index and increases the left ventricular myocardial mass, which consequently reduces the adverse effects on myocardial function.

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Section: Discussionmentioning

confidence: 99%

Correlation analysis of epicardial adipose tissue and ventricular myocardial strain in Chinese amateur marathoners using cardiac magnetic resonance

Wang

Song

et al. 2022

PLoS ONE

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“…Again, using novel molecular imaging probes as described above in Sections "Imaging Inflammation" and "Cardiovascular MR in HFpEF", it is now possible not only to assess key leukocyte populations within the myocardium, but also to measure myocardial fibrosis via cardiac extracellular volume. Additionally, the modulation of adipokine function (including a reduction in serum leptin) has been linked with altered epicardial fat deposition profiles [190,191], the changes of which can be straightforwardly assessed using imaging.…”

Section: A Future Role For Advanced Imaging In Hfpef?mentioning

confidence: 99%

Functional and Metabolic Imaging in Heart Failure with Preserved Ejection Fraction: Promises, Challenges, and Clinical Utility

Burrage

Lewis

Miller

2022

Cardiovasc Drugs Ther

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Heart failure with preserved ejection fraction (HFpEF) is recognised as an increasingly prevalent, morbid and burdensome condition with a poor outlook. Recent advances in both the understanding of HFpEF and the technological ability to image cardiac function and metabolism in humans have simultaneously shone a light on the molecular basis of this complex condition of diastolic dysfunction, and the inflammatory and metabolic changes that are associated with it, typically in the context of a complex patient. This review both makes the case for an integrated assessment of the condition, and highlights that metabolic alteration may be a measurable outcome for novel targeted forms of medical therapy. It furthermore highlights how recent technological advancements and advanced medical imaging techniques have enabled the characterisation of the metabolism and function of HFpEF within patients, at rest and during exercise.

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“…UCP-1 uncouples mitochondrial respiration from ATP production, thus facilitating non-shivering thermogenesis, which is involved in thermoregulation. In the absence of aponeurotic or connective tissues between the EAT and the myocardium, EAT provides a rich local source of free fatty acids that support the high energy demands of nearby cardiomyocytes, thus providing cardiac energy storage [8]. EAT also secretes multiple cytokines (such as adiponectin) that limit myocardial inflammation and fibrosis.…”

Section: Eat Histology and Physiologymentioning

confidence: 99%

Role of Epicardial Adipose Tissue in Triggering and Maintaining Atrial Fibrillation

Tian

2022

CVIA

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Atrial fibrillation is the most common arrhythmia leading to cardiogenic stroke. Without membranous sructure betweenepicardial adipose tissue and atrial myocardium, epicardial adipose tissue directly covers the surface of the atrial myocardium.The formation of an epicardial adipose tissue inflammatory microenvironment, fibrosis, infiltration by epicardialadipose tissue, autonomic dysfunction and oxidative stress are important mechanisms that trigger and maintainatrial fibrillation. Those mechanisms are reviewed herein.

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Adipose‐related microRNAs as modulators of the cardiovascular system: the role of epicardial adipose tissue

Abstract: information-section).

Cited by 13 publications

References 93 publications

Correlation analysis of epicardial adipose tissue and ventricular myocardial strain in Chinese amateur marathoners using cardiac magnetic resonance

Correlation analysis of epicardial adipose tissue and ventricular myocardial strain in Chinese amateur marathoners using cardiac magnetic resonance

Functional and Metabolic Imaging in Heart Failure with Preserved Ejection Fraction: Promises, Challenges, and Clinical Utility

Role of Epicardial Adipose Tissue in Triggering and Maintaining Atrial Fibrillation

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