Adipose microenvironment promotes hypersialylation of ovarian cancer cells
Alexandra Fox,
Garry D. Leonard,
Nicholas Adzibolosu
et al.
Abstract:Sialylation, the addition of negatively charged sialic acid sugars to terminal ends of glycans, is upregulated in most cancers. Hypersialylation supports multiple pro-tumor mechanisms such as enhanced migration and invasion, resistance to apoptosis and immune evasion. A current gap in knowledge is the lack of understanding on how the tumor microenvironment regulates cancer cell sialylation. The adipose niche is a main component of most peritoneal cancer microenvironments. This includes ovarian cancer (OC), whi… Show more
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