Adipose mesenchymal stem cell–derived exosomal microRNAs ameliorate polycystic ovary syndrome by protecting against metabolic disturbances

Cao, Maosheng; Zhao, Yun; Chen, Tong; Zhao, Zijiao; Zhang, Boqi; Yuan, Chengfeng; Wang, Xin; Chen, Lu; Wang, Nan; Li, Chunjin; Zhou, Xu

doi:10.1016/j.biomaterials.2022.121739

Cited by 25 publications

(11 citation statements)

References 56 publications

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“…Subsequently, different exosomal miRNAs have been demonstrated to be effective in preventing and treating PCOS. Adipose mesenchymal stem cellderived exosomal miRNA-21-5p increased the number of corpus luteum and reduced the number of abnormal cystic follicles by targeting Btg2 and activating the IRS1 and AKT signaling pathways in PCOS rats (Cao et al, 2022). In addition, demonstrated that the overexpression of miR-18b-5p derived from follicular fluid reduced the apoptosis of granulosa cells and attenuated the pathological effects in ovaries by targeting PTEN and activating the PI3K/Akt/mTOR signaling pathway in PCOS rats.…”

Section: Exosomes In the Treatment Of Pregnancy-related Diseasesmentioning

confidence: 84%

Exosomes: The role in mammalian reproductive regulation and pregnancy-related diseases

Guo

et al. 2023

Front. Physiol.

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Exosomes are a kind of extracellular vesicles that are produced and secreted by different mammalian cells. They serve as cargo proteins and can transfer different kinds of biomolecules, including proteins, lipids, and nucleic acids, which consequently act on target cells to exert different biological effects. Recent years have witnessed a significant increase in the number of studies on exosomes due to the potential effects of exosomes in the diagnosis and treatment of cancers, neurodegenerative diseases, and immune disorders. Previous studies have demonstrated that exosomal contents, especially miRNAs, are implicated in numerous physiological processes such as reproduction, and are crucial regulators of mammalian reproduction and pregnancy-related diseases. Here, we describe the origin, composition, and intercellular communication of exosomes, and discuss their functions in follicular development, early embryonic development, embryonic implantation, male reproduction and development of pregnancy-related diseases in humans and animals. We believe this study will provide a foundation for revealing the mechanism of exosomes in regulating mammalian reproduction, and providing new approaches and ideas for the diagnosis and treatment of pregnancy-related diseases.

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Section: Exosomes In the Treatment Of Pregnancy-related Diseasesmentioning

confidence: 84%

Exosomes: The role in mammalian reproductive regulation and pregnancy-related diseases

Guo

et al. 2023

Front. Physiol.

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“…We have identi ed micro-RNA species has-miR-21-5p, has-miR-335-5p, has-miR-146a-5p and has-miR-143-5p shared by the hub genes. These micro-RNAs have been linked to the development of PCOS [49][50][51] .…”

Section: Discussionmentioning

confidence: 99%

Discovering common pathogenetic processes between SARS-CoV-2 infection and polycystic ovary syndrome based on an integrated bioinformatics approach and experiment validation

Bai,

Zhang,

et al. 2024

Preprint

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The prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among polycystic ovary syndrome (PCOS) is significantly higher than in the general population. However, the mechanisms underlying this remain obscure. This study aimed to explore the mechanisms by identifying genetic signature of SARS-CoV-2 infection in PCOS. In the present study, a total of 27 common differentially expressed genes (DEGs) were selected for subsequent analyses. Functional analyses showed that immunity and hormone related pathways collectively participated in the development and progression of PCOS and SARS Cov-2 infection. Under these, 7 significant hub genes were identified, including S100A9, MMP9, TLR2, THBD, ITGB2, ICAM1, CD86 by using the algorithm in Cytoscape. Furthermore, hub genes expression was confirmed in validation set, PCOS clinical samples and mouse model. Immune microenvironment analysis with CIBERSORTx database demonstrated that the hub genes were significantly correlated with T cells, dendritic cells, mast cells, B cells, NK cells, eosinophils and positively correlated with immune scores. Among the hub genes, S100A9, MMP9, THBD, ITGB2, CD86 and ICAM1 exhibited preferable values as diagnostic makers for COVID-19 and PCOS. In addition, we established the interaction networks of ovary-specific genes, transcription factors, miRNAs, drugs, and chemical compounds with hub genes with NetworkAnalyst. This work uncovered the common pathogenesis and genetic signature of PCOS and SARS-CoV-2 infection, which might provide a theoretical basis and innovative ideas for further mechanistic research and drug discovery of the comorbidity of two diseases.

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“…SC-exos have demonstrated a wide range of capabilities in managing polycystic ovary syndrome (PCOS) and its complications. Specifically, ADSC-exos were able to enhance fertility and protect against the metabolic complications in rat models, particularly through the miR-21-5p-loaded exosomes which were found to enhance the hepatic metabolism by activating the insulin receptor substrate 1 (IRS1)/Akt pathway [ 131 ]. This alteration of hepatic metabolism is ultimately due to reduced btg2 transcription activity, thus promoting glucose uptake and reducing the degree of steatosis and fatty vacuoles [ 132 ].…”

Section: Potential Therapeutic Applications In Disease and Regenerati...mentioning

confidence: 99%

“…Subsequently, improved metabolic outcomes and fertility were displayed. Moreover, ADSC-exos also pose a structural benefit in PCOS, where there was a reduction in the number of cystic follicles and an increase in the number of corpora lutea and oocytes [ 131 ].…”

Section: Potential Therapeutic Applications In Disease and Regenerati...mentioning

confidence: 99%

Therapeutic Applications of Stem Cell-Derived Exosomes

Abdulmalek,

Husain,

AlKhalifa

et al. 2024

IJMS

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Exosomes are extracellular vesicles of endosomal origin, ranging from 30 to 150 nm in diameter, that mediate intercellular transfer of various biomolecules, such as proteins, lipids, nucleic acids, and metabolites. They modulate the functions of recipient cells and participate in diverse physiological and pathological processes, such as immune responses, cell–cell communication, carcinogenesis, and viral infection. Stem cells (SCs) are pluripotent or multipotent cells that can differentiate into various cell types. SCs can also secrete exosomes, which exhibit remarkable therapeutic potential for various diseases, especially in the field of regenerative medicine. For example, exosomes derived from mesenchymal stem cells (MSCs) contain proteins, lipids, and miRNAs that can ameliorate endocrine disorders, such as diabetes and cancer. Exosomes from SCs (sc-exos) may offer similar advantages as SCs, but with reduced risks and challenges. Sc-exos have lower tumorigenicity, immunogenicity, and infectivity. They can also deliver drugs more efficiently and penetrate deeper into tissues. In this review, we provide an overview of the recent advances in sc-exos and their therapeutic applications in various diseases, such as diabetes and cancer. We also elucidate how the biological effects of sc-exos depend on their molecular composition. We also address the current challenges and future directions of using sc-exos.

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Adipose mesenchymal stem cell–derived exosomal microRNAs ameliorate polycystic ovary syndrome by protecting against metabolic disturbances

Cited by 25 publications

References 56 publications

Exosomes: The role in mammalian reproductive regulation and pregnancy-related diseases

Exosomes: The role in mammalian reproductive regulation and pregnancy-related diseases

Discovering common pathogenetic processes between SARS-CoV-2 infection and polycystic ovary syndrome based on an integrated bioinformatics approach and experiment validation

Therapeutic Applications of Stem Cell-Derived Exosomes

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