Adipose lipid turnover and long-term changes in body weight

Arner, Peter; Bernard, Samuel; Appelsved, Lena; Fu, Keng‐Yeh; Andersson, Daniel P.; Salehpour, Mehran; Thorell, Anders; Spalding, Kirsty L.

doi:10.1038/s41591-019-0565-5

Cited by 104 publications

(109 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results suggested that GQD intervention is through a novel, non-TZD PPARg and PPARa dual signals to cause antihyperglycemic and TG-lowering effects, which jointly optimized the expression of target gene profiles to promote fatty acid oxidation and accelerate glucose uptake and utilization for more balanced glucose and lipid metabolism than PPARg full agonist rosiglitazone without stimulating PPARa activity ( Figure 10). PPARg and PPARa are opposite regulators of TG decomposition and synthesis, thus largely affect adipose lipid turnover (Arner et al, 2019). Thus, the metabolic effects on dynamic balance of lipid profiles in GQD treatment should be further investigated to establish clinic usage of GQD including diabetes, dyslipidemia, and obesity.…”

Section: A B Cmentioning

confidence: 99%

Gegen Qinlian Decoction Coordinately Regulates PPARγ and PPARα to Improve Glucose and Lipid Homeostasis in Diabetic Rats and Insulin Resistance 3T3-L1 Adipocytes

Zhu

et al. 2020

Front. Pharmacol.

View full text Add to dashboard Cite

transduction cascades, which jointly optimized the expression of target gene profiles to promote fatty acid oxidation and accelerate glucose uptake and utilization than PPARg full agonist rosiglitazone without stimulating PPARa activity. Thus, GQD showed antidiabetic/or antihyperglycemic effects, partially through regulating adipocytic PPARa and PPARg signaling systems to maintaining balanced glucose and lipid metabolisms. This study provides a new insight into the anti-diabetic effect of GQD as a PPARa/g dual agonist to accelerate the clinical use.

show abstract

Section: A B Cmentioning

confidence: 99%

Gegen Qinlian Decoction Coordinately Regulates PPARγ and PPARα to Improve Glucose and Lipid Homeostasis in Diabetic Rats and Insulin Resistance 3T3-L1 Adipocytes

Zhu

et al. 2020

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Weight gain occur across the adult lifespan, at reported rates of around 0.2-1 kg/year [1,2] in a non-linear manner [3] which, in addition to the physiological effects of ageing (e.g. reduced resting metabolic rate [4] and adipose lipid turnover [5]), may be a response to short periods of increased energy intake (EI) and/or decreased energy expenditure (EE) which are not subsequently compensated for [6]. These periods are often influenced by temporal factors (e.g.…”

Section: Introductionmentioning

confidence: 99%

Weekly, seasonal and holiday body weight fluctuation patterns among individuals engaged in a European multi-centre behavioural weight loss maintenance intervention

et al. 2020

View full text Add to dashboard Cite

Background Technological advances in remote monitoring offer new opportunities to quantify body weight patterns in free-living populations. This paper describes body weight fluctuation patterns in response to weekly, holiday (Christmas) and seasonal time periods in a large group of individuals engaged in a weight loss maintenance intervention. Methods Data was collected as part The NoHoW Project which was a pan-European weight loss maintenance trial. Three eligible groups were defined for weekly, holiday and seasonal analyses, resulting in inclusion of 1,421, 1,062 and 1,242 participants, respectively. Relative weight patterns were modelled on a time series following removal of trends and grouped by gender, country, BMI and age. Results Within-week fluctuations of 0.35% were observed, characterised by weekend weight gain and weekday reduction which differed between all groups. Over the Christmas period, weight increased by a mean 1.35% and was not fully compensated for in following months, with some differences between countries observed. Seasonal patterns were primarily characterised by the effect of Christmas weight gain and generally not different between groups.

show abstract

“…Adrb3 was observed in aged vs young rats. The possible relationship between the reduced expression of β3-adrenoceptor and NT3 in AT, and the previously described age-related changes in lipid metabolism [45] needs further investigation.…”

Section: Discussionmentioning

confidence: 94%

NT3/TrkC pathway modulates the expression of UCP-1 and adipocyte size in human and murine adipose tissue

Bové

Montó

Guillem-Llobat

et al. 2020

Preprint

View full text Add to dashboard Cite

NT3, through activation of its tropomyosin-related kinase receptor C (TrkC), modulates neuronal survival and neural stem cell differentiation. It is widely distributed in peripheral tissues (specially vessels and pancreas) and this ubiquitous pattern suggests a role for NT3, outside the nervous system and related to metabolic functions. The presence of the NT3/TrkC pathway in the adipose tissue (AT) has never been investigated. Present work studies in human and murine adipose tissue (AT) the presence of elements of the NT3/TrkC pathway and its role on lipolysis and adipocyte differentiation. qRT-PCR and immunoblot indicate that NT3 was present in human retroperitoneal AT and decreases with age. NT3 was also present in rat isolated adipocytes and retroperitoneal, interscapular, perivascular and perirenal AT. Histological analysis evidences that NT3 was mainly present in vessels irrigating AT close associated to sympathetic fibers. Similar mRNA levels of TrkC and β-adrenoceptors were found in all ATs assayed and in isolated adipocytes. NT3, through TrkC activation, exert a mild effect in lipolysis. Addition of NT3 during the differentiation process of human pre-adipocytes resulted in smaller adipocytes and increased uncoupling protein-1 (UCP-1) without changes in β-adrenoceptors. Similarly, transgenic mice with reduced expression of NT3 (Ntf3 knock-in lacZ reporter mice) or lacking endothelial NT3 expression (Ntf3flox1/flox2;Tie2-Cre+/0) displayed enlarged white and brown adipocytes and lower UCP-1 expression.ConclusionsNT3, mainly released by blood vessels, activates TrkC and regulates adipocyte differentiation and browning. Disruption of NT3/TrkC signaling conducts to hypertrophied white and brown adipocytes with reduced expression of the thermogenesis marker UCP-1

show abstract

Adipose lipid turnover and long-term changes in body weight

Cited by 104 publications

References 42 publications

Gegen Qinlian Decoction Coordinately Regulates PPARγ and PPARα to Improve Glucose and Lipid Homeostasis in Diabetic Rats and Insulin Resistance 3T3-L1 Adipocytes

Gegen Qinlian Decoction Coordinately Regulates PPARγ and PPARα to Improve Glucose and Lipid Homeostasis in Diabetic Rats and Insulin Resistance 3T3-L1 Adipocytes

Weekly, seasonal and holiday body weight fluctuation patterns among individuals engaged in a European multi-centre behavioural weight loss maintenance intervention

NT3/TrkC pathway modulates the expression of UCP-1 and adipocyte size in human and murine adipose tissue

Contact Info

Product

Resources

About