Adipose-derived stromal/stem cells and extracellular vesicles for cancer therapy

Hamilton, Gerhard; Teufelsbauer, Maryana

doi:10.1080/14712598.2021.1954156

Cited by 4 publications

(2 citation statements)

References 131 publications

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“…One week later, the expression of CD73 and STEM121 in the testis tissue of the control group (PBS + hUC-MSCs) and PTX + hUC-MSCs treatment group could still be detected. The results suggested that hUC-MSCs can survive for a long time in mouse testis tissue and exert effective paracrine immunomodulatory function to repair tissue damage [ 22 – 24 ]. After 2 weeks, significant changes in testicular morphology and key proteins related to spermatogenesis were identified in PTX-treated mice testis, and the application of hUC-MSCs (2 × 10 6 cells) significantly improved these changes and elevated antioxidant levels.…”

Section: Discussionmentioning

confidence: 99%

Human umbilical cord mesenchymal stem cells (hUC-MSCs) alleviate paclitaxel-induced spermatogenesis defects and maintain male fertility

et al. 2023

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Chemotherapeutic drugs can cause reproductive damage by affecting sperm quality and other aspects of male fertility. Stem cells are thought to alleviate the damage caused by chemotherapy drugs and to play roles in reproductive protection and treatment. This study aimed to explore the effects of human umbilical cord mesenchymal stem cells (hUC-MSCs) on alleviating paclitaxel (PTX)-induced spermatogenesis and male fertility defects. An in vivo PTX-induced mice model was constructed to evaluate the reproductive toxicity and protective roles of hUC-MSCs in male fertility improvement. A 14 day PTX treatment regimen significantly attenuated mice spermatogenesis and sperm quality, including affecting spermatogenesis, reducing sperm counts, and decreasing sperm motility. hUC-MSCs treatment could significantly improve sperm functional indicators. Mating experiments with normal female mice and examination of embryo development at 7.5 days post-coitum (dpc) showed that hUC-MSCs restored male mouse fertility that was reduced by PTX. In IVF experiments, PTX impaired sperm fertility and blastocyst development, but hUC-MSCs treatment rescued these indicators. hUC-MSCs’ protective role was also displayed through the increased expression of the fertility-related proteins HSPA2 and HSPA4L in testes with decreased expression in the PTX-treated group. These changes might be related to the PTX-induced decreases in expression of the germ cell proliferation protein PCNA and the meiosis proteins SYCP3, MLH1, and STRA8, which were restored after hUC-MSCs treatment. In the PTX-treated group, the expression of testicular antioxidant proteins SIRT1, NRF2, CAT, SOD1, and PRDX6 was significantly decreased, but hUC-MSCs could maintain these expressions and reverse PTX-related increases in BAX/BCL2 ratios. hUC-MSCs may be a promising agent with antioxidant and anti-apoptosis characteristics that can maintain sperm quality following chemotherapy treatment.

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Section: Discussionmentioning

confidence: 99%

Human umbilical cord mesenchymal stem cells (hUC-MSCs) alleviate paclitaxel-induced spermatogenesis defects and maintain male fertility

et al. 2023

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“…Such EVs have been shown to inhibit cancer cell growth, induce apoptosis and suppress epithelialmesenchymal transition in oral squamous cell carcinoma and cervical cancer [83,84]. Other approaches include vesicle loading with specific miRNAs, siRNAs, mRNAs, ncRNAs, proteins and peptides that have previously shown anti-tumour activity [69,85,86]. Some studies have reported the use of MSC-EVs to counteract chemoresistance in glioblastoma multiforme cells by delivering anti-miR-9, with promising results in reversing the chemoresistance of this tumour [87].…”

Section: Msc-derived Extracellular Vesiclesmentioning

confidence: 99%

Bioengineered Mesenchymal Stem/Stromal Cells in Anti-Cancer Therapy: Current Trends and Future Prospects

Gil-Chinchilla,

Zapata,

Moraleda

et al. 2024

Biomolecules

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Mesenchymal stem/stromal cells (MSCs) are one of the most widely used cell types in advanced therapies due to their therapeutic potential in the regulation of tissue repair and homeostasis, and immune modulation. However, their use in cancer therapy is controversial: they can inhibit cancer cell proliferation, but also potentially promote tumour growth by supporting angiogenesis, modulation of the immune milieu and increasing cancer stem cell invasiveness. This opposite behaviour highlights the need for careful and nuanced use of MSCs in cancer treatment. To optimize their anti-cancer effects, diverse strategies have bioengineered MSCs to enhance their tumour targeting and therapeutic properties or to deliver anti-cancer drugs. In this review, we highlight the advanced uses of MSCs in cancer therapy, particularly as carriers of targeted treatments due to their natural tumour-homing capabilities. We also discuss the potential of MSC-derived extracellular vesicles to improve the efficiency of drug or molecule delivery to cancer cells. Ongoing clinical trials are evaluating the therapeutic potential of these cells and setting the stage for future advances in MSC-based cancer treatment. It is critical to identify the broad and potent applications of bioengineered MSCs in solid tumour targeting and anti-cancer agent delivery to position them as effective therapeutics in the evolving field of cancer therapy.

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Regeneration and anti-inflammatory effects of stem cells and their extracellular vesicles in gynecological diseases

Zheng,

Zhao,

Liu

et al. 2023

Biomedicine & Pharmacotherapy

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Adipose-derived stromal/stem cells and extracellular vesicles for cancer therapy

Cited by 4 publications

References 131 publications

Human umbilical cord mesenchymal stem cells (hUC-MSCs) alleviate paclitaxel-induced spermatogenesis defects and maintain male fertility

Human umbilical cord mesenchymal stem cells (hUC-MSCs) alleviate paclitaxel-induced spermatogenesis defects and maintain male fertility

Bioengineered Mesenchymal Stem/Stromal Cells in Anti-Cancer Therapy: Current Trends and Future Prospects

Regeneration and anti-inflammatory effects of stem cells and their extracellular vesicles in gynecological diseases

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