Adipose-derived stem cells versus bone marrow-derived stem cells for vocal fold regeneration

Hiwatashi, Nao; Hirano, Shigeru; Mizuta, Masanobu; Tateya, Ichiro; Kanemaru, Shin‐ichi; Nakamura, Tatsuo; Ito, Juichi

doi:10.1002/lary.24816

Cited by 44 publications

(68 citation statements)

References 36 publications

(37 reference statements)

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“…We have conducted a comparative study in which scarred rat vocal folds were treated with a local injection of either BM-MSCs or ASCs. The results showed similar effects on recovery of hyaluronic acid in the vocal fold lamina propria, but ASCs showed greater ability to produce hyaluronic acid synthase and HGF [ 10 ].…”

Section: Autologous Stem Cellssupporting

confidence: 63%

Future Prospective

Hirano¹,

Kanemaru²

2015

Regenerative Medicine in Otolaryngology

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All human beings have the dream to one day completely regenerate damaged tissues and organs. The past three decades have seen the emergence and development of advanced tissue engineering and regenerative medicine and the great potential now exists to make this dream a reality. However, forecasting the future direction of tissue engineering and regenerative medicine is no simple matter. Within a span of less than 10 years, induced pluripotent stem cells (iPSCs) were established and the three-dimensional bioprinter (3D bioprinter) were developed. These innovations that seemed beyond the scope of our imagination have the potential to make remarkable progress and dramatic shifts in the medical fi eld.For simple tissues, such as skin and blood vessels, these innovations have achieved some marked success. However, there are major issues that limit the application of these strategies to complex tissues and organs. It is unreasonable to expect that simple implantation of organs created ex vivo into the living body will result in successful regeneration. Blood supply is an absolute requirement for engraftment into the host and innervation is also necessary for functional regeneration. The key to complete successful regeneration lies in the appropriate combination of cells, scaffolds, and regulatory factors, and critical to this is the creation of a favorable regenerative environment.The otolaryngology, head and neck fi eld, encompasses regions that consist of various organs and tissues that are critical for maintaining important functions such as mastication, articulation, phonation, respiration, and swallowing. These body systems also have several important neurosensory functions including hearing, balance, smell, and taste. Once these functions have deteriorated, quality of life (QOL) is greatly compromised. This fi eld represents one of the best opportunities where tissue engineering and regenerative medicine is expected to work as an innovative

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Section: Autologous Stem Cellssupporting

confidence: 63%

Future Prospective

Hirano¹,

Kanemaru²

2015

Regenerative Medicine in Otolaryngology

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“…Numerous previous studies have identified adipose-derived stem cells (ASCs) as a potential stem cell population with proliferation and differentiation ability similar to bone marrow-derived stem cells (BMSCs) [24–26]. ASCs are more easily isolated and can differentiate toward the osteogenic, chondrogenic, adipogenic, myogenic, neurogenic and angiogenic lineages [27–32].…”

Section: Discussionmentioning

confidence: 99%

Ginsenoside Rg1 and platelet-rich fibrin enhance human breast adipose-derived stem cells function for soft tissue regeneration

Liang

et al. 2016

Oncotarget

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Adipose-derived stem cells (ASCs) can be used to repair soft tissue defects, wounds, burns, and scars and to regenerate various damaged tissues. The cell differentiation capacity of ASCs is crucial for engineered adipose tissue regeneration in reconstructive and plastic surgery. We previously reported that ginsenoside Rg1 (G-Rg1 or Rg1) promotes proliferation and differentiation of ASCs in vitro and in vivio. Here we show that both G-Rg1 and platelet-rich fibrin (PRF) improve the proliferation, differentiation, and soft tissue regeneration capacity of human breast adipose-derived stem cells (HBASCs) on collagen type I sponge scaffolds in vitro and in vivo. Three months after transplantation, tissue wet weight, adipocyte number, intracellular lipid, microvessel density, and gene and protein expression of VEGF, HIF-1α, and PPARγ were higher in both G-Rg1- and PRF-treated HBASCs than in control grafts. More extensive new adipose tissue formation was evident after treatment with G-Rg1 or PRF. In summary, G-Rg1 and/or PRF co-administration improves the function of HBASCs for soft tissue regeneration engineering.

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“…In another study, Hiwatashi et al compared the effects of BM-MSCs and AD-MSCs in combination with atelocollagen for vocal fold scar regeneration. The authors showed that AD-MSCs had more potential in terms of restoration of hyaluronic acid and suppression of excessive collagen deposition (Hiwatashi et al, 2014;Hiwatashi et al, 2016). Both BM-MSCs and AD-MSCs were considered to have similar potential for treating methotrexate-induced pulmonary fibrosis in rat (Fikry et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Adipose derived stem cell transplantation is better than bone marrow mesenchymal stem cell transplantation in treating hindlimb ischemia in mice

Vu¹,

Phi²,

Dao³

et al. 2016

Biomed Res Ther

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Abstract-Introduction:Bone marrow derived MSCs (BM-MSCs) and adipose derived MSCs (AD-MSCs) are among the types of stem cells most commonly studied. Our study aims to compare the therapeutic efficacy of allograft AD-MSCs versus BM-MSCs in a mouse model of hindlimb ischemia. Methods: AD-MSCs were isolated from belly fat and BM-MSCs were isolated from femur bone marrow. They were used to treat mice with acute hindlimb ischemia. Treatment efficacy was compared among 4 groups: injected with BM-MSCs, injected with ADMSCs, non-treated and injected with phosphate buffered saline. Mice in the groups were evaluated for the following: necrosis grade of leg, leg edema, blood flow, muscle cell restructure and new blood vessel formation. Results: Results showed that AD-MSC transplantation significantly recovered acute limb ischemia, with 76.5% of mice fully recovered, while the ratio was only 48.5% in BM-MSC transplanted group, and 0% in the non-treated and PBS groups. Evaluation of leg edema, blood flow, muscle cell restructure and new blood vessel formation also supported the observation that AD-MSC transplantation was superior over BM-MSC transplantation. Conclusion: Therefore, AD-MSCs may serve as the more suitable MSC for hindlimb ischemia treatment and angiogenesis therapy.

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Adipose-derived stem cells versus bone marrow-derived stem cells for vocal fold regeneration

Abstract: N/A.

Cited by 44 publications

References 36 publications

Future Prospective

Future Prospective

Ginsenoside Rg1 and platelet-rich fibrin enhance human breast adipose-derived stem cells function for soft tissue regeneration

Adipose derived stem cell transplantation is better than bone marrow mesenchymal stem cell transplantation in treating hindlimb ischemia in mice

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