Adipose-derived stem cells loaded photocurable and bioprintable bioinks composed of GelMA, HAMA and PEGDA crosslinker to differentiate into smooth muscle phenotype

Atturu, Pavanchandh; Mudigonda, Sunaina; Wang, Chau-Zen; Wu, Shun-Cheng; Chen, Jhen-Wei; Forgia, Mary Fornica Francis; Dahms, Hans-Uwe; Wang, Chih-Kuang

doi:10.1016/j.ijbiomac.2024.130710

International Journal of Biological Macromolecules

2024

DOI: 10.1016/j.ijbiomac.2024.130710

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Adipose-derived stem cells loaded photocurable and bioprintable bioinks composed of GelMA, HAMA and PEGDA crosslinker to differentiate into smooth muscle phenotype

Pavanchandh Atturu,

Sunaina Mudigonda,

Chau-Zen Wang

et al.

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2024

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Cited by 3 publications

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A 3D hydrogel scaffold with adjustable interlayer spacing for the formation of compact myocardial tissue

Yang,

Xu,

Jin

et al. 2024

J of Applied Polymer Sci

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The design and optimization of three‐dimensional tissue scaffolds have presented a persistent challenge for myocardial tissue engineering. While current scaffolds have made strides in mimicking in vivo three‐dimensional environments, the presence of interlayer spacing has limited the formation of densely packed tissue, impeding cell‐to‐cell connections. We proposed a novel dynamic three‐dimensional myocardial tissue engineering scaffold with adjustable interlayer spacing, aiming to improve the uniformity of cell distribution and facilitate effective cell communication. The device was composed of hydrogel scaffolds that were fabricated with poly (ethylene glycol) diacrylate (PEGDA) and flexible elastomer actuators that composed of polyurethane acrylate (PUA). Human induced pluripotent stem cell‐derived cardiomyocytes mixed with gelatin methacryloyl (GelMA) were seeded onto the multi‐layered scaffold with initial spacing of 100–500 μm. Experimental results indicated the seeding efficiency was maximized at an initial spacing of 400 μm. By decreasing the interlayer spacing, cell growth morphology and gap junction protein expression was improved. This work demonstrated the effect of interlayer spacing modulation to the tissue density and provided a potential approach for cultivation of compact and multi‐layered myocardial tissue.

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A 3D hydrogel scaffold with adjustable interlayer spacing for the formation of compact myocardial tissue

Yang,

Xu,

Jin

et al. 2024

J of Applied Polymer Sci

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Hyaluronic acid methacrylate/Pluronic F127 hydrogel enhanced with spermidine-modified mesoporous polydopamine nanoparticles for efficient synergistic periodontitis treatment

Liu,

Wei,

Yang

et al. 2024

International Journal of Biological Macromolecules

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Biomimetic fabrication bioprinting strategies based on decellularized extracellular matrix for musculoskeletal tissue regeneration: Current status and future perspectives

Liu,

Xing,

et al. 2024

Materials & Design

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Adipose-derived stem cells loaded photocurable and bioprintable bioinks composed of GelMA, HAMA and PEGDA crosslinker to differentiate into smooth muscle phenotype

Cited by 3 publications

References 62 publications

A 3D hydrogel scaffold with adjustable interlayer spacing for the formation of compact myocardial tissue

A 3D hydrogel scaffold with adjustable interlayer spacing for the formation of compact myocardial tissue

Hyaluronic acid methacrylate/Pluronic F127 hydrogel enhanced with spermidine-modified mesoporous polydopamine nanoparticles for efficient synergistic periodontitis treatment

Biomimetic fabrication bioprinting strategies based on decellularized extracellular matrix for musculoskeletal tissue regeneration: Current status and future perspectives

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