Adipose-Derived Stem Cells Inhibit Epidermal Melanocytes through an Interleukin-6–Mediated Mechanism

Kim, Deok Woo; Jeon, Byung Joon; Hwang, Na Hyun; Kim, Min Sook; Park, Seung Ha; Dhong, Eun Sang; Yoon, Eul Sik; Lee, Byung Il

doi:10.1097/prs.0000000000000431

Cited by 31 publications

(18 citation statements)

References 44 publications

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“…20 To conform the paracrine effect of SVF, an in vitro study in 2014 by Kim et al . revealed that adipose mesenchymal cells-conditioned media down-regulated melanogenic enzymes and therefore inhibited melanocyte proliferation and melanin synthesis, 21 thereby decreasing the pigmentation of skin that contributes to the aging process. However, our direct transplantation of SVF into the nasolabial groove did not show any difference in skin pigmentation (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Rejuvenation of facial skin and improvement in the dermal architecture by transplantation of autologous stromal vascular fraction: a clinical study

Amirkhani¹,

Shoae-Hassani²,

Soleimani³

et al. 2016

Bioimpacts

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Introduction: The rejuvenation characteristics of fat tissue grafting has been established for many years. Recently it has been shown that stromal vascular fraction (SVF) of fat tissue contributes to its rejuvenation properties. As the SVF is a minimal processed cell population (based on FDA guidance), therefore it is a suitable cell therapy for skin rejuvenation. This clinical trial was aimed to evaluate the ultrastructural improvement of aging skin in the facial nasolabial region after transplantation of autologous SVF. Methods: Our study was conducted in 16 patients aged between 38 and 56 years old that were interested in face lifting at first. All of the cases underwent the lipoaspiration procedure from the abdomen for sampling of fat tissue. Quickly, the SVF was harvested from 100 mL of harvested fat tissue and then transplanted at dose of 2.0×107 nucleated cells in each nasolabial fold. The changes in the skin were evaluated using Visioface scanner, skin-scanner DUB, Visioline, and Cutometer with multi probe adopter. Results: By administration of autologous SVF, the elasticity and density of skin were improved significantly. There were no changes in the epidermis density in scanner results, but we noticed a significant increase in the dermis density and also its thickness with enrichment in the vascular bed of the hypodermis. The score of Visioface scanner showed slight changes in wrinkle scores. The endothelial cells and mesenchymal progenitors from the SVF were found to chang the architecture of the skin slightly, but there was not obvious phenotypic changes in the nasolabial grooves. Conclusion: The current clinical trial showed the modification of dermis region and its microvascular bed, but no changes in the density of the epidermis. Our data represent the rejuvenation process of facial skin by improving the dermal architecture.

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Section: Discussionmentioning

confidence: 99%

Rejuvenation of facial skin and improvement in the dermal architecture by transplantation of autologous stromal vascular fraction: a clinical study

Amirkhani¹,

Shoae-Hassani²,

Soleimani³

et al. 2016

Bioimpacts

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“…These factors and their receptors have an essential role in regulation of the inflammatory stage of wound healing and regeneration [ 116 , 117 , 118 ]. In addition, low doses of interleukins are found to have an anti-aging effect (see Table 1 ) and [ 119 , 120 ].…”

Section: Signaling Pathways Of Cellular Interactions Within Skinmentioning

confidence: 99%

Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging

Gaur

Dobke

Lunyak

2017

IJMS

143

114

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Operating at multiple levels of control, mesenchymal stem cells from adipose tissue (ADSCs) communicate with organ systems to adjust immune response, provide signals for differentiation, migration, enzymatic reactions, and to equilibrate the regenerative demands of balanced tissue homeostasis. The identification of the mechanisms by which ADSCs accomplish these functions for dermatological rejuvenation and wound healing has great potential to identify novel targets for the treatment of disorders and combat aging. Herein, we review new insights into the role of adipose-derived stem cells in the maintenance of dermal and epidermal homeostasis, and recent advances in clinical applications of ADSCs related to dermatology.

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“…In addition, TGF-β1 is a well-known dominant paracrine mediator, which determines the hyaluronic acid and collagen expression profiles [44]. Another group recently confirmed this effect and proposed that inhibition of melanin synthesis can be realized via interleukin-6 [45]. From this point of view, the fractional structure of skin hyperpigmentation can be theoretically connected with the local absence of ADSC paracrine activity.…”

Section: Mosaic Skin Structure - Is There a Link To Dwat Clusters Thamentioning

confidence: 99%

Dermal Adipocytes: From Irrelevance to Metabolic Targets?

Kruglikov¹,

Scherer

2016

Trends in Endocrinology & Metabolism

102

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Dermal white adipose tissue (dWAT) has found little appreciation in the past as a distinct entity from the better recognized subcutaneous white adipose tissue (sWAT). However, recent work has established dWAT as an important contributor to a multitude of processes, including immune response, wound healing and scarring, hair follicle growth and thermoregulation. Unique metabolic contributions are attributed to dWAT as well, at least in part due to thermic insulation properties and its response to cold exposure. Dermal adipocytes can also undergo adipocyte-myofibroblast transition (AMT), a process that is suspected to play an important role in a number of pathophysiological processes within the skin. Here, we discuss emerging concepts regarding dWAT physiology and its significance to a variety of cellular processes.

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Adipose-Derived Stem Cells Inhibit Epidermal Melanocytes through an Interleukin-6–Mediated Mechanism

Abstract: Adipose-derived stem cell-conditioned medium inhibited melanocyte proliferation and melanin synthesis by down-regulating melanogenic enzymes. Interleukin-6 plays a pivotal role in inhibition of melanocytes.

Cited by 31 publications

References 44 publications

Rejuvenation of facial skin and improvement in the dermal architecture by transplantation of autologous stromal vascular fraction: a clinical study

Rejuvenation of facial skin and improvement in the dermal architecture by transplantation of autologous stromal vascular fraction: a clinical study

Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging

Dermal Adipocytes: From Irrelevance to Metabolic Targets?

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