“…Stem cells have a unique capacity for self-renewal and multilineage differentiation as well as the potency to secrete various regulatory molecules, which contributes to forming a specialized niche and directing the development and regeneration of tissues [ 114 ]. ECMs derived from stem cells retain the specific functionality that can reflect in vivo microenvironment characteristics, and contain unique signaling networks to mediate cell behavior [ 115 , 116 ], which brings more opportunities to support peripheral nerve repair following injury. The ECMs derived from MSCs can effectively support stable cell expansion without heterogeneous reaction while maintaining the undifferentiated state of stem cells as well [ 117 ].…”