Adipose-derived exosomes block muscular stem cell proliferation in aged mouse by delivering miRNA Let-7d-3p that targets transcription factor HMGA2

Itokazu, Mansho; Onodera, Yuta; Mori, Tatsufumi; Inoue, Shunsuke; Yamagishi, Kotaro; Moritake, Akihiro; Iwawaki, Natsumi; Shigi, Kanae; Takehara, Toshiyuki; Higashimoto, Yuji; Akagi, Masao; Teramura, Takeshi

doi:10.1016/j.jbc.2022.102098

Cited by 9 publications

(5 citation statements)

References 50 publications

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“…These results imply that circulating senescence-associated EVs may originate from old skeletal muscle and may have direct effects on stem cell populations in tissues like bone through the transfer of their microRNA cargo. Another study has demonstrated that transplantation of exosomes derived from perimuscular adipose tissue (PMAT) to limb muscles results in a reduction in the number of α7/CD29-double positive myogenic progenitor cells ( Itokazu et al, 2022 ). Functional analysis has unveiled that let-7d-3p, present in exosomes from aged PMAT, regulates these cells by targeting HMGA2, a transcription factor crucial for stem cell self-renewal.…”

Section: Regulatory Mechanisms Of Non-coding Rnas In Muscle Agingmentioning

confidence: 99%

The role of non-coding RNAs in muscle aging: regulatory mechanisms and therapeutic potential

Shin,

Kwon,

Suh

et al. 2024

Front. Mol. Biosci.

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Muscle aging is a complex physiological process that leads to the progressive decline in muscle mass and function, contributing to debilitating conditions in the elderly such as sarcopenia. In recent years, non-coding RNAs (ncRNAs) have been increasingly recognized as major regulators of muscle aging and related cellular processes. Here, we comprehensively review the emerging role of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), in the regulation of muscle aging. We also discuss how targeting these ncRNAs can be explored for the development of novel interventions to combat age-related muscle decline. The insights provided in this review offer a promising avenue for future research and therapeutic strategies aimed at improving muscle health during aging.

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Section: Regulatory Mechanisms Of Non-coding Rnas In Muscle Agingmentioning

confidence: 99%

The role of non-coding RNAs in muscle aging: regulatory mechanisms and therapeutic potential

Shin,

Kwon,

Suh

et al. 2024

Front. Mol. Biosci.

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“…Additionally, it was noted that the Let-7d-3p miRNA, which specifically targets HMGA2, a crucial transcription factor involved in the self-renewal of stem cells, showed the ability to suppress cell proliferation in muscle stem/progenitor cells and impede the overall molecular processes occurring in aged adipocytes. The accumulation of Let-7d-3p in aged PMAT EVs is attributed to the diminished expression of Lin28 A/B and nuclear factor-kappa B signaling [ 238 ]. Metabolic abnormalities affecting adipose tissue typically lead to metabolic diseases in skeletal muscle.…”

Section: Targeting Muscle-bone-adipose Crosstalk For Therapeutic Inte...mentioning

confidence: 99%

Targeting Crosstalk of Signaling Pathways among Muscles-Bone-Adipose Tissue: A Promising Therapeutic Approach for Sarcopenia

2023

Aging dis

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The aging process is associated with the development of a wide range of degenerative disorders in mammals. These diseases are characterized by a progressive decline in function at multiple levels, including the molecular, cellular, tissue, and organismal. Furthermore, it is responsible for various healthcare costs in developing and developed countries. Sarcopenia is the deterioration in the quality and functionality of muscles, which is extremely concerning as it manages many functions in the human body. This article reviews the molecular crosstalk involved in sarcopenia and the specific roles of many mediator molecules in establishing cross-talk between muscles, bone, and fatty tissues, eventually leading to sarcopenia. Besides, the involvement of various etiological factors, such as neurology, endocrinology, lifestyle, etc., makes it exceedingly difficult for clinicians to develop a coherent hypothesis that may lead to the well-organized management system required to battle this debilitating disease. The several hallmarks contributing to the progression of the disease is a vital question that needs to be addressed to ensure an efficient treatment for sarcopenia patients. Also, the intricate molecular mechanism involved in developing this disease requires more studies. The direct relationship of cellular senescence with aging is one of the pivotal issues contributing to disease pathophysiology. Some patented treatment strategies have been discussed, including drugs undergoing clinical trials and emerging options like miRNA and protein-enclosed extracellular vesicles. A clear understanding of the secretome, including the signaling pathways involved between muscles, bone, and fatty tissues, is extremely beneficial for developing novel therapeutics for curing sarcopenia.

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“…Recently, the disruption of the relationship between AT and skeletal muscle has been recognized as potential causative factors, and perimuscular AT (PMAT) increases in parallel with muscle atrophy [ 84 ]. Itokazu et al, showed that the exosomes of PMAT of aged mice contained high levels of Let-7d-3p miRNA, which decreased the number of muscular stem/progenitor cells through targeting of HMGA2, an important transcription factor required for stem cell proliferation [ 63 ].…”

Section: Rnasmentioning

confidence: 99%

Adipose-Secreted Exosomes and Their Pathophysiologic Effects on Skeletal Muscle

Yue

Wang

Cai

et al. 2022

IJMS

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Due to its prominent secretory activity, adipose tissue (AT) is now considered a major player in the crosstalk between organs, especially with skeletal muscle. In which, exosomes are effective carriers for the intercellular material transfer of a wide range of molecules that can influence a series of physiological and pathological processes in recipient cells. Considering their underlying roles, the regulatory mechanisms of adipose-secreted exosomes and their cellular crosstalk with skeletal muscle have received great attention in the field. In this review, we describe what is currently known of adipose-secreted exosomes, as well as their applications in skeletal muscle pathophysiology.

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Adipose-derived exosomes block muscular stem cell proliferation in aged mouse by delivering miRNA Let-7d-3p that targets transcription factor HMGA2

Cited by 9 publications

References 50 publications

The role of non-coding RNAs in muscle aging: regulatory mechanisms and therapeutic potential

The role of non-coding RNAs in muscle aging: regulatory mechanisms and therapeutic potential

Targeting Crosstalk of Signaling Pathways among Muscles-Bone-Adipose Tissue: A Promising Therapeutic Approach for Sarcopenia

Adipose-Secreted Exosomes and Their Pathophysiologic Effects on Skeletal Muscle

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