Adipose, bone and muscle tissues as new endocrine organs: role of reciprocal regulation for osteoporosis and obesity development

Migliaccio, Silvia; Greco, Emanuela A.; Wannenes, Francesca; Donini, Lorenzo Maria; Lenzi, Andrea

doi:10.1515/hmbci-2013-0070

Cited by 39 publications

(38 citation statements)

References 140 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…LMI and waist-to-height ratio (an index of accumulation of abdominal fat concerning CRT exposure) played, respectively, a positive and a negative effect on cortical bone mass in this sample of ALL subjects, which concurs with previous studies [1][2][3][4]24]. Bone metabolism might be impaired in obesity, reflected by decreased osteoblastogenesis and/or increased osteoclastogenesis, and low bone mass [24].…”

Section: Discussionsupporting

confidence: 90%

“…However, fat accumulation can also affect bone through the direct effect of adipokines or indirectly through the state of chronic inflammation [1][2][3][4][5]. Low bone mass, sarcopenia, and obesity are commonly observed in the process of aging, and recent evidence has suggested a potential interconnection between these findings with common pathophysiology, even though this interaction is still poorly understood [1,2,6].…”

Section: Introductionmentioning

confidence: 99%

“…As regards adipokines (e.g., leptin, adiponectin, resistin, and visfatin), which are factors produced by the adipose tissue and biomarkers of metabolic syndrome (MS), leptin and adiponectin are by far the more studied. However, their role in bone mass acquisition and metabolism is not clear to date [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Visfatin is a positive predictor of bone mineral density in young survivors of acute lymphocytic leukemia

et al. 2015

View full text Add to dashboard Cite

Bone mass acquisition may be compromised in survivors of childhood acute lymphocytic leukemia due to various factors, including adiposity. Fat accumulation can affect bone through the direct effect of adipokines or indirectly through the state of chronic inflammation. The aim of this study was to evaluate the effect of body composition and adipokines on bone mass in survivors of acute lymphocytic leukemia. This was a cross-sectional study of 56 survivors aged between 15 and 24 years, 44.6 % of whom received cranial radiotherapy (18-24 Gy), assessed according to body fat, lean mass, and bone mineral density (dual energy X-ray absorptiometry), computed tomography scan-derived abdominal adipose tissue, and adipokines by a multiple regression analysis. Both lumbar spine L-L (trabecular bone) and total body (cortical bone) bone mineral density were positively correlated with visfatin (p < 0.050). Lean mass index was positively correlated, while waist-to-height ratio was negatively correlated with cortical bone (p < 0.010). Low bone mineral density for chronological age was detected in 5.4 % of patients in total body, and 8.9 % at the lumbar spine. In survivors of acute lymphocytic leukemia, visfatin may play an important role in the complex relationship between body composition and bone. At present, visfatin may represent a model for further study of bone metabolism, and could possibly explain the unknown mechanisms linking bone metabolism and cancer.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Visfatin is a positive predictor of bone mineral density in young survivors of acute lymphocytic leukemia

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Numerous genes and environmental risk factors, each with a small effect on the disorder, determine polygenic disorders. Osteoporosis is a polygenic disease influenced by genetic and environmental factors along with the interaction between these factors . So far, however, the majority of genes associated with osteoporosis pathogenesis remain largely anonymous .…”

Section: Introductionmentioning

confidence: 99%

Novel insights into the complex architecture of osteoporosis molecular genetics

Saad

2019

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

Osteoporosis is a prevalent osteodegenerative disease and silent killer linked to a decrease in bone mass and decline of bone microarchitecture, due to impaired bone matrix mineralization, raising the risk of fracture. Nevertheless, the process of bone matrix mineralization is still an unsolved mystery. Osteoporosis is a polygenic disorder associated with genetic and environmental risk factors; however, the majority of genes associated with osteoporosis remain largely unknown. Several signaling pathways regulate bone mass; therefore, dysregulation of a single signaling pathway leads to metabolic bone disease owing to high or low bone mass. Parathyroid hormone, core‐binding factor α‐1 (Cbfa1), Wnt/β‐catenin, the receptor activator of the nuclear factor kappa‐B (NF‐κB) ligand (RANKL), myostatin, and osteogenic exercise signaling pathways play pivotal roles in the regulation of bone mass. The myostatin signaling pathway increases bone resorption by activating the RANKL signaling pathway, whereas osteogenic exercise inhibits myostatin and sclerostin while inducing irisin that consequentially activates the Cbfa1 and Wnt/β‐catenin bone formation pathways. The aims of this review are to summarize what is known about osteoporosis‐related signaling pathways; define the role of these pathways in osteoporosis drug discovery; focus light on the link between bone, muscle, pancreas, and adipose integrative physiology and osteoporosis; and underline the emerging role of osteogenic exercise in the prevention of, and care for, osteoporosis, obesity, and diabetes.

show abstract

“…W ith the increase in population age and the prevalence of obesity, it is important to understand the relationship between adipose tissue and bone mass, bone quality and fractures (1,2). Greater body weight or body fat mass have been known to have a positive effect on bone mineral density (BMD), but obesity is not protective against fractures.…”

mentioning

confidence: 99%

The Role of Bone Marrow Fat in Skeletal Health: Usefulness and Perspectives for Clinicians

Paccou

Hardouin

Cotten

et al. 2015

The Journal of Clinical Endocrinology &Amp; Metabolism

View full text Add to dashboard Cite

We conclude that most human data demonstrate an inverse relationship between BMF and BMD, but data on the relationship with fractures are inconsistent and need further study. In daily practice, the usefulness for clinicians of assessing BMF using magnetic resonance imaging is still limited. However, the perspectives are exciting, particularly in terms of improving the diagnosis and management of osteoporosis.

show abstract

Adipose, bone and muscle tissues as new endocrine organs: role of reciprocal regulation for osteoporosis and obesity development

Cited by 39 publications

References 140 publications

Visfatin is a positive predictor of bone mineral density in young survivors of acute lymphocytic leukemia

Visfatin is a positive predictor of bone mineral density in young survivors of acute lymphocytic leukemia

Novel insights into the complex architecture of osteoporosis molecular genetics

The Role of Bone Marrow Fat in Skeletal Health: Usefulness and Perspectives for Clinicians

Contact Info

Product

Resources

About