ADIPOQ-rs2241766 polymorphism is associated with changes in cholesterol levels of Mexican adolescents

León-Cachón, Rafael B. R.; Salinas-Santander, Mauricio; Aguilar-Tamez, Daniela Alejandra; MarianaValdez-Ortiz, Paola; Ríos-Ibarra, Clara Patricia; Cepeda‐Nieto, Ana Cecilia; Suárez-Valencia, Víctor de Jesús; Morlett-Chávez, Jesús Antonio

doi:10.32725/jab.2022.017

Cited by 2 publications

(1 citation statement)

References 33 publications

(37 reference statements)

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“…According to the literature, homozygous carriers of the rs2241766 variant showed a higher risk of developing Type 2 diabetes and insulin resistance in the Japanese population; in addition, the GG genotype has been associated with T2DM in Chinese, Finnish, and Iraqi populations [33,46]. In the Mexican population, homozygotes for this variant had significantly higher cholesterol levels [35]. These variants also showed an association with higher BMI values in a study conducted among residents of Moscow, Russia [34].…”

Section: Variants In Adipoqmentioning

confidence: 99%

Rare Variants of Obesity-Associated Genes in Young Adults with Abdominal Obesity

Bairqdar,

Shakhtshneider,

Ivanoshchuk

et al. 2023

JPM

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The increase in the prevalence of overweight, obesity and associated diseases is a serious problem. The aim of the study was to identify rare variants in obesity-associated genes in young adults with abdominal obesity in our population and to analyze information about these variants in other populations. Targeted high-throughput sequencing of obesity-associated genes was performed (203 young adults with an abdominal obesity phenotype). In our study, all of the 203 young adults with abdominal obesity had some rare variant in the genes associated with obesity. The widest range of rare and common variants was presented in ADIPOQ, FTO, GLP1R, GHRL, and INS genes. The use of targeted sequencing and clinical criteria makes it possible to identify carriers of rare clinically significant variants in a wide range of obesity-associated genes and to investigate their influence on phenotypic manifestations of abdominal obesity.

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Section: Variants In Adipoqmentioning

confidence: 99%

Rare Variants of Obesity-Associated Genes in Young Adults with Abdominal Obesity

Bairqdar,

Shakhtshneider,

Ivanoshchuk

et al. 2023

JPM

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The Association between ADIPOQ Gene Polymorphisms and Diabetic Retinopathy Risk: A Systematic Review and Meta-Analysis

Flindris,

Markozannes,

Moschos

et al. 2024

Medicina

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Background and Objectives: Recent studies have focused on the association between the risk of diabetic retinopathy (DR) and the rs1501299 and rs2241766 polymorphisms of the ADIPOQ gene; however, their results remain inconclusive. Thus, a systematic review and meta-analysis were carried out to clarify the role of these polymorphisms in the development of DR. Materials and Methods: A systematic search of electronic databases (PubMed, Scopus, and Cochrane Library) was conducted until 25 June 2024, and a reference list of relevant articles was collected, which explored the association between the rs1501299 and rs2241766 polymorphisms of the ADIPOQ gene and the risk of DR. The pooled odds ratios (OR) and 95% confidence intervals (CI) were estimated via random-effects model, and the meta-analysis was implemented by using Review Manager 5.4. Results: In total, 6 out of 182 studies, with 1888 cases (DR) and 2285 controls (without DR), were included in the meta-analysis. A statistically significant association between the rs1501299 polymorphism and the DR risk was recorded in G vs. T in the overall analysis (OR = 0.84, 95% CI = 0.72–0.99, p = <0.05, I2 = 23%, n = 5 studies). Additionally, the summary results in the subgroup analysis according to the control type were as follows: the DR versus diabetes mellitus (DM) control type revealed a statistically significant association in G vs. T: OR = 0.81, 95% CI = 0.67–0.97, p = <0.05, I2 = 27%, n = 4 studies; GG vs. GT: OR = 0.72, 95% CI = 0.53–0.98, p = <0.05, I2 = 49%, n = 4 studies; GG vs. (GT + TT): OR = 0.73, 95% CI = 0.55–0.96, p = <0.05, I2 = 44%, n = 4 studies. No significant association was observed between the rs2241766 polymorphism and the DR risk. Conclusions: The current meta-analysis supports the association between the rs1501299 polymorphism of the ADIPOQ gene and the DR risk in patients with DM.

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ADIPOQ-rs2241766 polymorphism is associated with changes in cholesterol levels of Mexican adolescents

Cited by 2 publications

References 33 publications

Rare Variants of Obesity-Associated Genes in Young Adults with Abdominal Obesity

Rare Variants of Obesity-Associated Genes in Young Adults with Abdominal Obesity

The Association between ADIPOQ Gene Polymorphisms and Diabetic Retinopathy Risk: A Systematic Review and Meta-Analysis

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