ADIPOQ and LEP variants on asthma and atopy: Genetic association modified by overweight

Coelho, Raísa Santos; Melo, Ana Paula Castro; Silva, Hátilla dos Santos; Silva, Rita De Cassia Ribeiro; Matos, Sheila Maria Alvim; Barreto, Maurício Lima; Alcântara-Neves, Neuza Maria; Figueiredo, Camila Alexandrina; Costa, Ryan dos Santos

doi:10.1016/j.gene.2021.145540

Cited by 12 publications

(6 citation statements)

References 49 publications

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“…Finally, it has recently been described that the polymorphism rs13228377 of the leptin gene is associated with higher levels of leptin in serum in asthma and those two variables (polymorphism + elevation in leptin) have a high predictive value for asthma risk (OR = 17.5, predictive accuracy 83.9%), although the authors themselves recognise the limitation of the scant sample [64]. In addition, it has been described that the single nucleotide polymorphisms (SNPs) of the leptin and adiponectin genes have a protective effect for asthma, but that that effect is lost in obese individuals [65].…”

Section: The Role Of Adipokines and Insulin Resistancementioning

confidence: 99%

Nutrition, Obesity and Asthma Inception in Children. The Role of Lung Function

Sánchez-Solís

García‐Marcos

2021

Nutrients

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Obesity is an important public health problem. WHO estimates that about 39 million children younger than 5 years of age are overweighted or obese. On the other hand, asthma is the most prevalent chronic disease in childhood, and thus, many children share those two conditions. In the present paper we review the epidemiology of children with asthma and obesity, as well as the consequences of being obese on the respiratory system. On the one hand obesity produces an underlying T-helper 2 (TH2) low inflammation state in which numerous cytokines, which could have an impact in the respiratory system play, a role. On the other hand, some respiratory changes have been described in obese children and, specially, the development of the so called “dysanapsis” (the disproportionate scaling of airway dimensions to lung volume) which seems to be common during the first stages of life, probably related to the early development of this condition. Finally, this review deals with the role of adipokines and insulin resistance in the inception and worsening of asthma in the obese child.

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Section: The Role Of Adipokines and Insulin Resistancementioning

confidence: 99%

Nutrition, Obesity and Asthma Inception in Children. The Role of Lung Function

Sánchez-Solís

García‐Marcos

2021

Nutrients

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“… 146 In Brazil, protection against asthma and atopy attributed to variants on the genes for leptin (LEP) and adiponectin (ADIPOQ) were lost in overweight individuals. 147 A study among Puerto Rican children exposed to violence showed an association between greater methylation of the anxiety regulating gene, ADCYAP1R1 , and asthma. 148 A significant interaction in Brazilian children was observed between variants on ORMDL3 and seropositivity for the Varicella zoster virus (i.e., the association with asthma was observed only among seropositives).…”

Section: Host Genetics and Ancestralitymentioning

confidence: 99%

“…A genome‐wide interaction study from Puerto Rico showed that dust mite allergen exposure appeared to modify the effect of a variant on chromosome 8q24.13 on FEV 1 in asthmatic children 146 . In Brazil, protection against asthma and atopy attributed to variants on the genes for leptin (LEP) and adiponectin (ADIPOQ) were lost in overweight individuals 147 . A study among Puerto Rican children exposed to violence showed an association between greater methylation of the anxiety regulating gene, ADCYAP1R1 , and asthma 148 .…”

Section: Host Genetics and Ancestralitymentioning

confidence: 99%

Understanding and controlling asthma in Latin America: A review of recent research informed by the SCAALA programme

Cooper

Figueiredo

Rodríguez

et al. 2023

Clinical & Translational All

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Asthma is an important health concern in Latin America (LA) where it is associated with variable prevalence and disease burden between countries. High prevalence and morbidity have been observed in some regions, particularly marginalized urban populations. Research over the past 10 years from LA has shown that childhood disease is primarily non‐atopic. The attenuation of atopy may be explained by enhanced immune regulation induced by intense exposures to environmental factors such as childhood infections and poor environmental conditions of the urban poor. Non‐atopic symptoms are associated with environmental and lifestyle factors including poor living conditions, respiratory infections, psychosocial stress, obesity, and a diet of highly processed foods. Ancestry (particularly African) and genetic factors increase asthma risk, and some of these factors may be specific to LA settings. Asthma in LA tends to be poorly controlled and depends on access to health care and medications. There is a need to improve management and access to medication through primary health care. Future research should consider the heterogeneity of asthma to identify relevant endotypes and underlying causes. The outcome of such research will need to focus on implementable strategies relevant to populations living in resource‐poor settings where the disease burden is greatest.

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“…Polymorphisms of the ADIPOQ gene, in particular the G allele of rs822396 and T allele of rs1063537, were associated with an increased risk for asthma, while variants rs11760956, rs11763517 and rs2167270 were protective [225]. Both polymorphisms were related to low ADPN [226] and asthma [123].…”

Section: Obesity-related Asthmamentioning

confidence: 99%

“…Both polymorphisms were related to low ADPN [226] and asthma [123]. Interestingly, the protection was lost in overweight individuals [225]. We do not know if this corresponds to the reduced expression of AdipoR1 in overweight patients and the "recuperation" of normal expression in severe obese patients [178].…”

Section: Obesity-related Asthmamentioning

confidence: 99%

Adiponectin and Asthma: Knowns, Unknowns and Controversies

Oțelea

Arghir

Zugravu

et al. 2021

IJMS

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Adiponectin is an adipokine associated with the healthy obese phenotype. Adiponectin increases insulin sensitivity and has cardio and vascular protection actions. Studies related to adiponectin, a modulator of the innate and acquired immunity response, have suggested a role of this molecule in asthma. Studies based on various asthma animal models and on the key cells involved in the allergic response have provided important insights about this relation. Some of them indicated protection and others reversed the balance towards negative effects. Many of them described the cellular pathways activated by adiponectin, which are potentially beneficial for asthma prevention or for reduction in the risk of exacerbations. However, conclusive proofs about their efficiency still need to be provided. In this article, we will, briefly, present the general actions of adiponectin and the epidemiological studies supporting the relation with asthma. The main focus of the current review is on the mechanisms of adiponectin and the impact on the pathobiology of asthma. From this perspective, we will provide arguments for and against the positive influence of this molecule in asthma, also indicating the controversies and sketching out the potential directions of research to complete the picture.

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ADIPOQ and LEP variants on asthma and atopy: Genetic association modified by overweight

Cited by 12 publications

References 49 publications

Nutrition, Obesity and Asthma Inception in Children. The Role of Lung Function

Nutrition, Obesity and Asthma Inception in Children. The Role of Lung Function

Understanding and controlling asthma in Latin America: A review of recent research informed by the SCAALA programme

Adiponectin and Asthma: Knowns, Unknowns and Controversies

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