Adiponectin, Vitamin D and Nutritional Status in Patients With Advanced Colorectal Cancer or During Follow-Up

Cavagnari, Mariana Abe Vicente; Vidigal, Verônica Marques; Silva, Tiago Donizetti; Barão, Katia; Nm, Forones

doi:10.1590/s0004-2803.201900000-34

Cited by 3 publications

(7 citation statements)

References 32 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, higher blood LEP concentration was associated with radical tumor excision and higher TNFalpha with nonsurgical perioperative complications. Our study corroborates the work by Cavagnari et al [8], who show that BMI, FM, vitamin D, and blood ADP concentration are not significant prognostic factors in CRC patients undergoing surgery. However, the other reference data do not provide clear evidence of associations between obesity, adipocytokine level, and CRC surgery outcomes, for either colon or rectal tumors [2].…”

Section: Discussionsupporting

confidence: 93%

“…Obesity is also associated with an increased risk of CRC-related mortality [1], although some authors have shown that the association between cancer treatment outcome and body weight is J-shaped (the "obesity paradox") [5]. Adipocytokines, which are hormonal substances secreted by adipocytes, have been proposed as one of the potential mediating factors in the association between patient nutritional status and the risk of carcinogenesis [6][7][8], CRC surgery outcomes (lymph node retrieval, margins, recurrence, survival, etc.) [2,9,10], perioperative complications [11], infection [12], response to chemotherapy [13], chemotherapy-associated hepatotoxicity due to liver steatosis [2], and the risk of neoplasmatic cachexia and frailty [14].…”

Section: Introductionmentioning

confidence: 99%

“…[2,9,10], perioperative complications [11], infection [12], response to chemotherapy [13], chemotherapy-associated hepatotoxicity due to liver steatosis [2], and the risk of neoplasmatic cachexia and frailty [14]. However, not all the evidence in the literature confirms these potential relationships [8,[15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

“…ADP is secreted through abdominal fat tissue in 2 isoforms: high-molecular weight and non-high-molecular weight; however, it is frequently determined as total ADP [16,33]. ADP exerts anti-diabetic, anti-atherosclerotic, and anti-inflammatory effects [2,8,12,16,21,30,33] and directly modulates several intracellular signaling pathways involved in colorectal carcinogenesis [8,16,[32][33][34][35][36][37]. ADP single-nucleotide polymorphisms (ADIPOQ rs2241766 T>G, rs1501299 G>T, rs266729 C>G) [38,39], low blood ADP concentration [37][38][39][40][41], and reduced ADP receptor (Adipo-R1/-R2) expression are considered risk factors for CRC [42].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Circulating Leptin, Adiponectin, and Tumor Necrosis Factor-Alpha in Patients Undergoing Surgery Due to Colorectal Cancer

et al. 2019

View full text Add to dashboard Cite

Background: Adipocytokines have been proposed as factors mediating associations between obesity and inflammation in patients with colorectal cancer (CRC). Thus, the aim of this study was to determine the clinical relationships between blood concentrations of leptin (LEP), adiponectin (ADP), and tumor necrosis factor alpha (TNF-alpha) and the outcomes measured in patients with CRC undergoing surgery. Patients and Methods: History, body composition, and blood concentrations of LEP, ADP, and TNF-alpha were determined in 107 patients undergoing surgery due to CRC. The patients were followed up for 619.72 ± 371.65 days. Results: Compared to patients with stage II CRC, individuals with clinical stage I CRC had significantly lower ADP and higher TNF-alpha blood concentrations. We found significant correlations between the clinical stage of CRC (early vs. localized vs. metastatic) and the following: crude blood ADP concentration (R = 0.25; p = 0.015), ADP-to-TNF-alpha ratio (R = 0.31; p = 0.002), and ADP when indexed to body surface area (R = 0.25; p = 0.008) and to fat mass (R = 0.25; p = 0.016). The risk of death during the long-term follow-up period was independently related to the clinical stage of CRC, impairment of the patient’s functional status, and higher blood carcinoembryonic antigen concentration. In Kaplan-Meier survival analysis, patients with blood LEP concentrations adjusted to a visceral adipose tissue score of ≥0.47 had a significantly better likelihood of surviving than their counterparts. Conclusions: In patients with CRC undergoing surgery, blood ADP and TNF-alpha concentrations were associated with the clinical stage of the cancer, likelihood of radical tumor excision, occurrence of nonsurgical postoperative complications, and long-term survival, which suggests the role of dysregulation in the endocrine function of adipose tissue in response to the neoplasmatic process.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Circulating Leptin, Adiponectin, and Tumor Necrosis Factor-Alpha in Patients Undergoing Surgery Due to Colorectal Cancer

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Therefore, if uptake of plasma insulin by peripheral tissue elevates, a reduced risk of CRC can be expected (16). Consequently, more studies on hormone adiponectin and its association with cancer are required (17,18). Adiponectin has revers correlation with obesity and hyperinsulinemia and insulin resistance (15,19).…”

Section: Introductionmentioning

confidence: 99%

Effect of Insulin Resistance and Role of Plasma Adiponectin Level in Susceptibility to Colorectal Cancer

2022

ircmj

View full text Add to dashboard Cite

Background: Despite clinical and basic different investigations, the role of plasma adipokines, such as adiponectin as a precise predictor of the risk of colorectal cancer (CRC) is still conflicting. Aim: This study investigated the association between CRC and insulin resistance, obesity, and plasma adiponectin level for the first time in Iran. Method: A total of 80 subjects (including 45 CRC patients and 35 healthy individuals) were enrolled in this case-control study. Demographic, anthropometric, and clinical data were recorded, and serum levels of adiponectin, insulin, and glucose were evaluated using enzyme-linked immunosorbent assay and glucose oxidase technique, respectively. Insulin resistance index (HOMA-IR) was measured as well. Results: The mean±SD plasma adiponectin concentration of the CRC patients (7.98±0.64 ng/ml) was not significantly higher, compared to that in the control group (8.05±1.14 ng/mL). The mean±SD of HOMA-IR and plasma glucose levels (1.81±0.61 and 7.64±1.34 mm/L, respectively) of the CRC group were significantly higher (P<0.05), compared to the control group (1.37±0.3 and 119±1.1 mg/dL, respectively); however, plasma insulin wasn’t significantly different in the two study groups. Following the stratification of CRC patients according to the tumor site, a significantly lower level of adiponectin (7.36 ±1.1 ng/ml) (P<0.05) and a significantly higher level of HOMA-IR (2.08±0.44) were observed in patients with colon cancer (P<0.005), compared to the controls. Regression among the plasma adiponectin and the plasma insulin and HOMA was negative in the control and CRC groups. Conclusion: Insulin resistance has an important role in the development of CRC, especially in genesis colon cancer, regardless of the change that it causes in plasma levels of adiponectin

show abstract

The Potential of Phase Angle as a Nutritional Assessment Tool and Prognostic Factor in Patients with Gastrointestinal Cancers

Mantzorou¹,

Tolia²,

Pavlidou³

et al. 2022

AustinJNutriFoodSci

View full text Add to dashboard Cite

Malnutrition is a common finding in patients with cancer and can significantly affect disease progress and patients’ survival. Gastrointestinal Cancers (GIC) are amongst the most common cancer types. In gastroin-testinal cancer patients, the prevalence of malnutrition has been estimated to be around 39-67%. Body composition reflects the nutritional status. Bio-Impedance Analysis (BIA) is a noninvasive, time- and cost-effective technique to analyse body composition. This review paper aims to critically summarise the currently available clinical data on the efficiency of the easily obtainable BIA measure, Phase Angle (PA), in the evaluation of malnutrition in GIC patients and on disease progression and prognosis. PubMed database was thoroughly searched, in order to identify clinical studies that explore the role of BIA- derived raw data and weight loss on disease prognosis and progress, as well on assessing malnutrition. Phase angle may be used as a nutritional screening tool in patients with gastrointestinal cancers. However, it cannot distinguish between stages of cachexia. Concerning the role of PA as a prognostic factor, current studies show that PA may be used as a prognostic factor of survival, yet further studies are needed for firm conclusions regarding post-operative complications and disease characteristics. Due to the fact that gastrointestinal cancers are a group of various cancers, further studies should be undertaken, in order to evaluate the role of BIA and PA on all gastrointestinal cancer sites and types.

show abstract

Adiponectin, Vitamin D and Nutritional Status in Patients With Advanced Colorectal Cancer or During Follow-Up

Cited by 3 publications

References 32 publications

Circulating Leptin, Adiponectin, and Tumor Necrosis Factor-Alpha in Patients Undergoing Surgery Due to Colorectal Cancer

Circulating Leptin, Adiponectin, and Tumor Necrosis Factor-Alpha in Patients Undergoing Surgery Due to Colorectal Cancer

Effect of Insulin Resistance and Role of Plasma Adiponectin Level in Susceptibility to Colorectal Cancer

The Potential of Phase Angle as a Nutritional Assessment Tool and Prognostic Factor in Patients with Gastrointestinal Cancers

Contact Info

Product

Resources

About