Adiponectin SNP45TG is associated with gestational diabetes mellitus

Abstract

We concluded that SNP45TG in adiponectin gene is associated with the occurrence of GDM.

Identification of Genetic Variants of Gestational Diabetes in South Indians

“…Earlier studies have reported the significant association of the SNPs GCK (rs1799884 and rs4607517), IGF2BP2 (rs4402960), KCNJ11 (rs5219), MTNR1A (rs2119882), MTNR1B (rs1387153 and rs10830963), SRR (rs391300), and TCF7L2 (rs12255372) with GDM in whites and Asians, mainly Koreans, Chinese, and Malayasians. 4,[16][17][18][19][20] The TCF7L2 gene SNP rs12255372 showed only a moderate significant association (P = 0.054) with GDM in the present study, although this SNP has previously shown association with T2DM in Asian Indians. 30 The association of rs12255372 with GDM has been reported in other populations like Mexican Americans, whites, and Koreans.…”

“…Recent studies have shown that the T2DM-associated gene variants were also found to be associated with GDM susceptibility. 4,[16][17][18][19][20] Among the genes that were investigated in the present study, CDKAL1 is the only gene that showed association with GDM in our south Indian population. Both SNPs of the CDKAL1 gene-rs7754840 and rs7756992-showed association with GDM even after Bonferroni's correction with a power of 61% and 82%, respectively.…”

“…9,11 Several studies, including genome-wide association studies (GWASs) and meta-analysis reports, have provided evidence that GDM and T2DM may share similar risk factors and genetic background. [12][13][14][15][16][17] Recently, replication of T2DM-associated genes identified in various GWASs has been carried out in GDM patients in different Asian populations from Korea, China, and Malaysia, 4,[18][19][20] but there are no data for Asian Indians, to the best of our knowledge. Although the genetics of T2DM have been extensively studied in Asian Indians using different approaches such as candidate gene and GWAS, [21][22][23][24][25][26][27][28][29] GDM, which is probably one of the early indicators of future occurrence of T2DM in women, has not been well studied in India.…”

Shared Genomics of Type 2 and Gestational Diabetes Mellitus

“…G allele of rs2241766 is signifi cantly more frequent in women with GDM (32.7%) than those with normal glucose (17.9%, p ϭ .038) in Malaysians (Low et al, 2010). Similar to prior work (Ranheim et al, 2004), Low and colleagues (2010) also reported a significantly lower plasma adiponectin level during early pregnancy in women with GDM than those without ( p Ͻ .05).…”

“…These genes have also been studied in women with GDM of various races, including Americans, Europeans, Mediterraneans, Asians, and Arabians. The number of women with GDM included in these studies ranged greatly from 25 (Low, Mohd Tohit, Chong, & Idris, 2010) to 930 (Shin et al, 2010). Sample size powered at least 80% was reported in only 6 of 24 studies (King, 2007;Lauenborg et al, 2009;Pappa et al, 2011;Shaat et al, 2005;Zhou et al, 2009).…”