Adiponectin-Secretion-Promoting Phenylethylchromones from the Agarwood of Aquilaria malaccensis

Abstract

The therapeutic potential of adiponectin regulation has received interest because of its association with diverse human disease conditions, such as diabetes, obesity, atherosclerosis, and cancer. Phenylethylchromone derivatives from Aquilaria malaccensis-derived agarwood promoted adiponectin secretion during adipogenesis in human bone marrow mesenchymal stem cells, and 5,6-dihydroxy-2-(2-phenylethyl)­chromone (1) was identified as a new chromone derivative. A target identification study with the most potent adiponectin-secretion-promoting phenylethylchromones, 6-methoxy-2-(2-phenylethyl)­chromone (3) and 7-methoxy-2-(2-phenylethyl)­chromone (4), showed that they are PPARγ partial agonists. Therefore, the diverse therapeutic effects of agarwood are associated with a PPARγ-mediated adiponectin-secretion-promoting mechanism.

Sesquiterpenoids and 2-(2-Phenylethyl)chromone Derivatives from the Resinous Heartwood of Aquilaria sinensis

“…S39). Daphnauranol A (6) [7], daphnauranol B (7) [7], 2-(2-phenylethyl)chromone (8) [10], 6-methoxy-2-(2-phenylethyl)chromone (9) [11], 6-methoxy-2-[2-(3-methyoxyphenyl)ethyl]chromone (10) [11], 6,7-dimethoxy-2-(2-phenylethyl)chromone (11) [11], 6,7-dimethoxy-2-[2-(4-methoxyphenyl)ethyl]chromone (13) [12], isoagarotetrol (14) [13], 1-hydroxy-1,5-diphenylpentan-3-one( 16) [14], and 3-hydroxy-1,5-diphenylpentan-1-one (17) [14] were determined by comparing their obtained spectroscopic data with those reported in the literature.…”

Cyclin-Dependent Kinase 5 Inhibitor Butyrolactone I Elicits a Partial Agonist Activity of Peroxisome Proliferator-Activated Receptor γ

“…PV4658). CLARIOstar (BMG LABTECH, Ortenberg, Germany) was used for the TR-FRET assay measurements and the instrument settings were the same as previously described [3].…”

“…A phenotype-based screening approach is advantageous for chronic diseases associated with diverse etiologies, such as atherosclerosis, obesity, and diabetes. The adipogenesis model of human bone marrow mesenchymal stem cells (hBM-MSCs) has been used for phenotypic screening of metabolic diseases by measuring adiponectin [2,3]. Adiponectin is a major adipocyte-secreting cytokine that regulates various metabolic functions, such as glucose homeostasis and fatty acid oxidation [4].…”

Aloeswood In; Hadith, Current Distribution And Trend Of Research Based On PMC

“…Notably, most papers are contributing to conventional medicine represent by a total of 11 (Hwang & Jung, 2018;Yan et al, 2018;Ismail et al, 2017;Nguyen et al, 2017;Chippa & Kaushik, 2017;Arai, Yamaguchi & Ishibashi, 2017;Sen, Dehingia & Talukdar, 2017;Min et al, 2016;Devi, Begum & Ahmaruzzaman, 2016;Korinek et al, 2016& Wong, Chin & Perlmutter, 2015. It is followed by a fraction of alternative medicine which contributes 6 papers (Ahn et al, 2019;Ma et al, 2017;Wagh et al, 2017;Lee et al, 2017;Canli, Yetgin & Akata, 2016& Alam et al, 2017, then a paper concerns on veterinary (Baruah, Malik & Kolte, 2018). Among contributors for the papers on alternative medicine, Wagh et al 2017 On the other hand, there is 1 paper out of the total 19 papers, demonstrates concern to the ailing environmental condition relating to the species Aquilaria malaccensis .…”