Adiponectin Protects Against Hyperoxic Lung Injury and Vascular Leak

Sliman, Sean M.; Patel, Rishi B.; Cruff, Jason; Kotha, Sainath R.; Newland, Christie A.; Schrader, Carrie A.; Sherwani, Shariq I.; Gurney, Travis O.; Magalang, Ulysses J.; Parinandi, Narasimham L.

doi:10.1007/s12013-011-9330-1

Cited by 16 publications

(14 citation statements)

References 68 publications

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“…Further, in an in vivo experiment, adiponectin‐overexpressing transgenic mice had significantly lower levels of lipid peroxidation products (hypoxia‐induced) compared with wild‐type mice. The levels of GSH were also higher in the lungs of the transgenic mice compared with wild‐type ().…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress and inflammatory markers in relation to circulating levels of adiponectin

Gustafsson

Lind

Söderberg

et al. 2013

Obesity

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Objective: Previous epidemiological studies together with animal studies have suggested an association between adiponectin and oxidative stress and inflammation, but community-based studies are lacking. Our objective was to investigate the relative importance of oxidative stress and inflammatory markers, representing different pathways in relation to adiponectin. Design and Methods: In a cross-sectional sample of 929 70-year-old individuals (50% women) of the Prospective Investigation of the Vasculature in Uppsala Seniors study, relations between serum adiponectin and oxidative stress [conjugated dienes (CD), homocysteine, total antioxidant capacity, oxidized low-density lipoprotein (OxLDL), OxLDL antibodies, baseline CD of LDL, glutathione (GSH), total glutathione (TGSH), glutathione disulfide], circulation interleukins (IL-6, IL-8), other cytokines [tumor necrosis factor a, monocyte chemotactic protein-1 (MCP-1), epidermal growth factor (EGF), vascular endothelial growth factor], cell adhesion molecules (vascular cell adhesion molecule-1, intercellular adhesion molecule-1, E-selectin, P-selectin, L-selectin), and systemic inflammatory markers [C-reactive protein (CRP), leukocyte count] in separate models were investigated. Results: In age-and sex-adjusted, as well as multivariable-adjusted models, adiponectin was significantly and positively associated with GSH, log TGSH, whereas an inverse association was observed for CD and log EGF. An inverse association between adiponectin and MCP-1, log E-selectin, and log CRP was significant in age-and sex-adjusted models, but not in multivariable-adjusted models. Conclusions: Our results imply that higher levels of adiponectin are associated with a more beneficial oxidative stress profile, with higher levels of principal anti-oxidative GSH and total GSH together with lower levels of lipid peroxidation, possibly through shared pathways. Further studies are needed to investigate whether changes in the oxidative stress profile may be a mechanism linking adiponectin with type 2 diabetes and/or cardiovascular disease.

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Section: Discussionmentioning

confidence: 99%

Oxidative stress and inflammatory markers in relation to circulating levels of adiponectin

Gustafsson

Lind

Söderberg

et al. 2013

Obesity

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“…Furthermore, adiponectin can be transported from circulation to alveolar through T-cadherin on the endothelium. These support its potential roles in lung injury [62, 63]. Lung injury is a complicated pathogenesis process, including activation of immune system and inflammation, stimulation of endothelium, increased capillary permeability, neutrophil and macrophage infiltration, and leaking of albumin [64, 65].…”

Section: Obesity Inflammation and Lung Injury: The Goodmentioning

confidence: 92%

Obesity, Inflammation, and Lung Injury (OILI): The Good

Wang

2014

Mediators of Inflammation

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Obesity becomes pandemic, predisposing these individuals to great risk for lung injury. In this review, we focused on the anti-inflammatories and addressed the following aspects: adipocytokines and obesity, inflammation and other mechanisms, adipocytokines and lung injury in obesity bridged by inflammation, and potential therapeutic targets. To sum up, the majority of evidence supported that adiponectin, omentin, and secreted frizzled-related protein 5 (SFRP5) were reduced significantly in obesity, which is associated with increased inflammation, indicated by increase of TNFα and IL-6, through activation of toll-like receptor (TLR4) and nuclear factor light chain κB (NF-κB) signaling pathways. Administration of these adipocytokines promotes weight loss and reduces inflammation. Zinc-α2-glycoprotein (ZAG), vaspin, IL-10, interleukin-1 receptor antagonist (IL-1RA), transforming growth factor β (TGF-β1), and growth differentiation factor 15 (GDF15) are also regarded as anti-inflammatories. There were controversial reports. Furthermore, there is a huge lack of studies for obesity related lung injury. The effects of adiponectin on lung transplantation, asthma, chronic obstructive pulmonary diseases (COPD), and pneumonia were anti-inflammatory and protective in lung injury. Administration of IL-10 agonist reduces mortality of acute lung injury in rabbits with acute necrotizing pancreatitis, possibly through inhibiting proinflammation and strengthening host immunity. Very limited information is available for other adipocytokines.

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“…Another potential limitation is that a dose response was not done for LPS and rAPN. Transgenic mice with APN levels three times greater than wild-type mice are protected from hyperoxic lung injury (Sliman et al, 2013). Thus, in preliminary experiments using newborn rats, we determined the dose and time to achieve plasma APN levels two to three times greater than baseline levels after IP injection.…”

Section: Discussionmentioning

confidence: 99%

Recombinant adiponectin protects the newborn rat lung from lipopolysaccharide‐induced inflammatory injury

et al. 2020

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Preterm infants are at high risk for developing bronchopulmonary dysplasia and pulmonary hypertension from inflammatory lung injury. In adult models, adiponectin (APN)—an adipocyte‐derived hormone—protects the lung from inflammatory injury and pulmonary vascular remodeling. Cord blood APN levels in premature infants born < 26 weeks gestation are 5% of the level in infants born at term. We previously reported the expression profile of APN and its receptors in neonatal rat lung homogenates during the first 3 weeks of postnatal development. Here, we characterize the expression profile of APN and its receptors in specific lung cells and the effects of exogenous recombinant APN (rAPN) on lipopolysaccharide‐(LPS)‐induced cytokine and chemokine production in total lung homogenates and specific lung cells. In vitro, rAPN added to primary cultures of pulmonary artery smooth muscle cells attenuated the expression of LPS‐induced pro‐inflammatory cytokines while increasing the expression of anti‐inflammatory cytokines. In vivo, intraperitoneal rAPN (2 mg/kg), given 4 hr prior to intrapharyngeal administration of LPS (5 mg/kg) to newborn rats at postnatal day 4, significantly reduced gene and protein expression of the pro‐inflammatory cytokine IL‐1ß and reduced protein expression of the chemokines monocyte chemoattractant protein (MCP‐1) and macrophage inflammatory protein‐1 alpha (MIP‐1α) in the lung. LPS‐induced histopathological changes in the lung were also decreased. Moreover, rAPN given 20 hr after intrapharyngeal LPS had a similar effect on lung inflammation. These findings suggest a role for APN in protecting the lung from inflammation during early stages of lung development.

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Adiponectin Protects Against Hyperoxic Lung Injury and Vascular Leak

Cited by 16 publications

References 68 publications

Oxidative stress and inflammatory markers in relation to circulating levels of adiponectin

Oxidative stress and inflammatory markers in relation to circulating levels of adiponectin

Obesity, Inflammation, and Lung Injury (OILI): The Good

Recombinant adiponectin protects the newborn rat lung from lipopolysaccharide‐induced inflammatory injury

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