Adiponectin multimer distribution, not absolute amount of plasma, correlates with depression severity in healthy elderly subjects

Narita, Kosuke; Murata, Tetsuhito; Hamada, Toshihiko; Takahashi, Tetsuya; Kosaka, Hirotaka; Sudo, Satoru; Mizukami, Kimiko; Yoshida, Haruyoshi; Wada, Yuji

doi:10.1016/j.pnpbp.2007.07.022

Cited by 15 publications

(6 citation statements)

References 25 publications

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“…Men with MDD also tended to have lower adiponectin than did controls 26 . Our findings contrast, however, with data from two other reports 28, 29 . Both evaluated older populations, and one utilized broad inclusion criteria for depression, and did not exclude subjects with comorbid illnesses.…”

Section: Discussioncontrasting

confidence: 99%

Low 24-Hour Adiponectin and High Nocturnal Leptin Concentrations in a Case-Control Study of Community-Dwelling Premenopausal Women With Major Depressive Disorder

Cizza

Nguyen

Eskandari

et al. 2010

J. Clin. Psychiatry

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Objective Major depressive disorder (MDD) is associated with immune system dysfunction and disruption of multiple circadian systems. Adiponectin is an adipocytokine with anti-inflammatory and anti-atherogenic effects. Circulating concentrations are inversely related to adiposity and risks of metabolic syndrome and diabetes mellitus. Our goals were to: A) establish whether premenopausal women with MDD exhibit decreased plasma adiponectin concentrations and/or disruption of circadian adiponectin rhythmicity; B) assess whether there is a relationship between adiponectin and MDD; C) explore the temporal relationships among adiponectin, leptin, ACTH and cortisol secretion. Method Case-control study of community-dwelling premenopausal women with MDD and age- and BMI-matched-control subjects (N=23/group). Main outcome measures were circulating concentrations of adiponectin, leptin, ACTH, and cortisol measured hourly for 24h. Results Women with MDD had approximately 30% lower mean 24h concentrations of adiponectin than did control subjects. Adiponectin was inversely related to depression severity and total duration of disease, suggesting a causal link. In contrast, nocturnal leptin concentrations were higher in the MDD versus control groups. Leptin was inversely related to cortisol and adiponectin both in subjects with depression and in control subjects. In cross-correlation analyses, the relationship between ACTH and cortisol was stronger in women with MDD than in control subjects, consistent with HPA-axis activation in MDD. Conclusions Reduced daily adiponectin production may increase the risk of diabetes mellitus, and elevated leptin may contribute to osteoporosis, in premenopausal women with MDD.

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Section: Discussioncontrasting

confidence: 99%

Low 24-Hour Adiponectin and High Nocturnal Leptin Concentrations in a Case-Control Study of Community-Dwelling Premenopausal Women With Major Depressive Disorder

Cizza

Nguyen

Eskandari

et al. 2010

J. Clin. Psychiatry

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“…High molecular weight adiponectin/total adiponectin was also negatively associated with the depression score (19). In addition, numerous studies had other views.…”

Section: A B C Discussionmentioning

confidence: 96%

Adiponectin and depression: A meta-analysis

Dong

Chen

2014

Biomedical Reports

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Abstract. Adiponectin has been indicated to be linked with depression. In the present study, a meta-analysis was performed to evaluate the association between adiponectin levels and depression. Six studies with a total of 4,220 subjects were selected for inclusion in the analysis. The references were retrieved via PubMed, Cochrane Central Register of Controlled Trials and Embase, and the following Chinese databases: The China National Knowledge Infrastructure, China Biology Medicine disc, VIP Database for Chinese Technical Periodicals and Wan Fang Data. The analyses were performed using Review Manager 5.2 software. The standardized mean difference (SMD) with 95% confidence intervals (CIs) was assessed following pooling the collected data for analysis. A significant association was detected between adiponectin levels and depression in European populations. In the European group of patients with depression, improvements were observed in adiponectin levels (SMD, -5.00 µg/ml, 95% CI, -7.13 to -2.88). The current meta-analysis indicates that patients with patients had a lower adiponectin level when compared to healthy patients in European groups.

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“…Larger studies, if possible, with a prospective design are needed to extend the significance of the observations made here with respect to development of obesity‐related metabolic complication in children. It would also be of interest to explore which molecular forms of adiponectin (30) that are expressed in different tissues at different ages.…”

Section: Discussionmentioning

confidence: 99%

Adiponectin and peroxisome proliferator‐activated receptor γ expression in subcutaneous and omental adipose tissue in children

Li¹,

Lindquist²,

Angsten³

et al. 2008

Acta Paediatrica

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Adiponectin multimer distribution, not absolute amount of plasma, correlates with depression severity in healthy elderly subjects

Cited by 15 publications

References 25 publications

Low 24-Hour Adiponectin and High Nocturnal Leptin Concentrations in a Case-Control Study of Community-Dwelling Premenopausal Women With Major Depressive Disorder

Low 24-Hour Adiponectin and High Nocturnal Leptin Concentrations in a Case-Control Study of Community-Dwelling Premenopausal Women With Major Depressive Disorder

Adiponectin and depression: A meta-analysis

Adiponectin and peroxisome proliferator‐activated receptor γ expression in subcutaneous and omental adipose tissue in children

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