Adiponectin mediates the additive effects of combining daily exercise with caloric restriction for treatment of non-alcoholic fatty liver

Cho, J; Koh, Yeojung; Han, Ji Min; Kim, D; Kim, T; Kang, Hyunah

doi:10.1038/ijo.2016.104

Cited by 15 publications

(23 citation statements)

References 38 publications

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“…Our results are consistent with the notion that early in obesity reversal, rapid normalization of dysglycemia is matched by a robust improvement in hepatic steatosis and metabolism (though not insulin signaling responsiveness) (Jung et al . 2013, Cho et al . 2016).…”

Section: Discussionmentioning

confidence: 99%

Adipose tissue supports normalization of macrophage and liver lipid handling in obesity reversal

Vatarescu

Bechor

Haim

et al. 2017

Journal of Endocrinology

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Adipose tissue inflammation and dysfunction are considered central in the pathogenesis of obesity-related dysmetabolism, but their role in the rapid metabolic recovery upon obesity reversal is less well defined. We hypothesized that changes in adipose tissue endocrine and paracrine mechanisms may support the rapid improvement of obesity-induced impairment in cellular lipid handling. C57Bl-6J mice were fed ad libitum either normal chow (NC) or high-fat diet (HFF) for 10 weeks. A dietary obesity reversal group was fed HFF for 8 weeks and then switched to NC for 2 weeks (HFF→NC). Whole-body glucose homeostasis rapidly nearly normalized in the HFF→NC mice (fasting glucose and insulin fully normalized, glucose and insulin tolerance tests reversed 82% to the NC group levels). During 2 weeks of the dietary reversal, the liver was significantly cleared from ectopic fat, and functionally, glucose production from pyruvate, alanine or fructose was normalized. In contrast, adipose tissue inflammation (macrophage infiltration and polarization) largely remained as in HFF, though obesity-induced adipose tissue macrophage lipid accumulation decreased by ~50%, and adipose tissue MAP kinase hyperactivation was reversed. Ex vivo, mild changes in adipose tissue adipocytokine secretion profile were noted. These corresponded to partial or full reversal of the excess cellular lipid droplet accumulation induced by HFF adipose tissue conditioned media in hepatoma or macrophage cells, respectively. We propose that early after initiating reversal of nutritional obesity, rapid metabolic normalization largely precedes resolution of adipose tissue inflammation. Nevertheless, we demonstrate a hitherto unrecognized contribution of adipose tissue to the rapid improvement in lipid handling by the liver and by macrophages.

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Section: Discussionmentioning

confidence: 99%

Adipose tissue supports normalization of macrophage and liver lipid handling in obesity reversal

Vatarescu

Bechor

Haim

et al. 2017

Journal of Endocrinology

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“…Even when the diagnosis is achieved, treatment is not easily established, as there are no approved drugs for treatment. Several treatment protocols are suggested and applied by clinicians and researchers, yet there is no consensus among experts and clinicians on medical treatment (7). Generally, a combination of modified diet and exercise is recommended for treatment (8).…”

Section: Introductionmentioning

confidence: 99%

Green Tea in Non-Alcoholic Fatty Liver Disease: A Double Blind Randomized Clinical Trial

et al. 2017

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Objectives: Antioxidant treatment with Iron chelating agents is one of the suggested treatments for fatty liver disease, which has become an important health problem in the recent decades. In this study the authors evaluated the general antioxidant, iron chelating, and sugar and fat absorption characteristics of green tea. Methods: Patients with non-alcoholic fatty liver disease were randomly assigned to 2 groups for a double blind clinical trial. Patients in the intervention group received 550 milligrams of green tea tablets daily as well as nutritional education for 3 months. The control group received the same protocol with green tea replaced with placebo tablets. Results: After 3 months, 45 participants (21 in the intervention and 24 in the placebo group) completed the follow-up. The change in body mass index (BMI), aspartate aminotransferase (AST), and fasting blood sugar (FBS) was significantly different between the 2 groups, while the change in total iron binding capacity (TIBC), ferritin, alanine transaminase (ALT), HOMA, and weight did not show a significant difference. Conclusions:The difference between the 2 groups was mainly observed in anthropometrics, liver enzyme, and metabolic indicators, although the difference might not have been highlighted due to the effectiveness of routine treatments, that both groups received.

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“…Thus, it is considered that DsbA‐L may play a key role in the development and progression of NAFLD, especially in obese populations. In the present study, the association between DsbA‐L polymorphism and the median ratio of HMW to total adiponectin, which is related to protection against adipose tissue inflammation and insulin resistance, was more pronounced in overweight subjects than in the overall study population ( Figure ). However, we did not find any direct effects of DsbA‐L polymorphism on the risk of NAFLD, even in overweight subjects (Eqs.…”

Section: Discussionmentioning

confidence: 52%

“…Adiponectin, an adipose tissue-specific hormone, has been reported to be associated with the protection against adipose tissue inflammation, insulin resistance, and mitochondrial dysfunction and to have an important role in the prevention of obesity and its related diseases. [8][9][10] Plasma adiponectin exists as a low-molecular-weight trimer, medium-molecular-weight hexamer, and high-molecularweight (HMW) oligomer. 10 HMW oligomers of adiponectin are the major relevant forms for improving insulin sensitivity, anti-inflammatory and antidiabetic activities, and low levels of HMW oligomers represent an independent risk factor for several metabolic diseases.…”

Section: What Does This Study Add To Our Knowledge?mentioning

confidence: 99%

“…Adiponectin, an adipose tissue‐specific hormone, has been reported to be associated with the protection against adipose tissue inflammation, insulin resistance, and mitochondrial dysfunction and to have an important role in the prevention of obesity and its related diseases . Plasma adiponectin exists as a low‐molecular‐weight trimer, medium‐molecular‐weight hexamer, and high‐molecular‐weight (HMW) oligomer .…”

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confidence: 99%

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Modeling of the Weight Status and Risk of Nonalcoholic Fatty Liver Disease in Elderly Individuals: The Potential Impact of the Disulfide Bond‐Forming Oxidoreductase A‐Like Protein (DsbA‐L) Polymorphism on the Weight Status

Oniki

Watanabe

Kudo

et al. 2018

CPT Pharmacom & Syst Pharma

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Nonalcoholic fatty liver disease (NAFLD) is closely associated with obesity. Disulfide bond‐forming oxidoreductase A‐like protein (DsbA‐L) is known to be a key molecule in protection against obesity and obesity‐induced inflammation. In the present study, we used a modeling and simulation approach in an attempt to develop body mass index (BMI) and BMI‐based NAFLD prediction models incorporating the DsbA‐L polymorphism to predict the BMI and NAFLD in 341 elderly subjects. A nonlinear mixed‐effect model best represented the sigmoidal relationship between the BMI and the logit function of the probability of NAFLD prevalence. The final models for BMI and NAFLD showed that DsbA‐L rs1917760 polymorphism, age, and gender were associated with the BMI, whereas gender, patatin‐like phospholipase 3 rs738409 polymorphism, HbA1c, and high‐density and low‐density lipoprotein cholesterol levels were associated with the risk of NAFLD. This information may aid in the genetic‐based prevention of obesity and NAFLD in the general elderly population.

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Adiponectin mediates the additive effects of combining daily exercise with caloric restriction for treatment of non-alcoholic fatty liver

Abstract: The current findings provide experimental evidence in favor of the combination of EX and CR as a superior strategy for NAFLD treatment than EX or CR alone.

Cited by 15 publications

References 38 publications

Adipose tissue supports normalization of macrophage and liver lipid handling in obesity reversal

Adipose tissue supports normalization of macrophage and liver lipid handling in obesity reversal

Green Tea in Non-Alcoholic Fatty Liver Disease: A Double Blind Randomized Clinical Trial

Modeling of the Weight Status and Risk of Nonalcoholic Fatty Liver Disease in Elderly Individuals: The Potential Impact of the Disulfide Bond‐Forming Oxidoreductase A‐Like Protein (DsbA‐L) Polymorphism on the Weight Status

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