Adiponectin levels, lipid proﬁle and glucose metabolism in patients with abdomi-nal obesity

Belyaeva, O.; Баженова, Е. А.; Березина, А. В.; Большакова, О. О.; Chubenko, E.; Гаранина, А Е; Баранова, Е. И.; Беркович, О. А.; Shlyakhto, E

doi:10.18705/1607-419x-2009-15-3-309-313

Cited by 8 publications

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Одной из причин увеличения ТИМ ОСА при АО является дисбаланс адипокинов, обусловленный прежде всего снижением уровня адипонектина. По нашим данным, уровень ОАН у женщин с АО был ниже, чем у здоровых женщин, что совпадает с данными других исследователей о роли висцерального жира в развитии гипоадипонектинемии [31,32].…”

Section: Discussionunclassified

Common Carotid Intima–Media Thickness, Levels of Total and High-Molecular Weight Adiponectin in Women With Abdominal Obesity

Brovin

Belyaeva

Pchelina

et al. 2018

CARDIO

Self Cite

View full text Add to dashboard Cite

Section: Discussionunclassified

Common Carotid Intima–Media Thickness, Levels of Total and High-Molecular Weight Adiponectin in Women With Abdominal Obesity

Brovin

Belyaeva

Pchelina

et al. 2018

CARDIO

Self Cite

View full text Add to dashboard Cite

Predictors of Effectiveness of Glucagon-Like Peptide-1 Receptor Agonist Therapy in Patients with Type 2 Diabetes and Obesity

Бабенко

Savitskaya

Kononova

et al. 2019

Journal of Diabetes Research

View full text Add to dashboard Cite

Rationale. It is well known that diabetes mellitus (DM) exacerbates the mechanisms underlying atherosclerosis. Currently, glucagon-like peptide-1 receptor agonists (aGLP-1) have one of the most prominent cardioprotective effects among the antidiabetic agents. However, the treatment with aGLP-1 is effective only in 50-70% of the cases. Taking into account the high cost of these medications, discovery of the predictors of optimal response to treatment is required. Purpose. To identify the predictors of the greater impact of aGLP-1 on HbA1c levels, weight reduction, and improvement in lipid profile. Methods. The study group consisted of 40 patients with type 2 DM (T2DM) and obesity who were treated with aGLP-1. The follow-up period was 24 weeks. Patients’ evaluation was conducted at baseline and after 24 weeks. In addition, it included the assessment of the hormones involved in glucose and lipid metabolism and appetite regulation. Results. Patients who have initially higher BMI (body mass index), glycemia, and triglycerides (TG) had better improvement in these parameters undergoing aGLP-1 treatment. In patients with a BMI loss≥5%, GLP-1 and fasting ghrelin levels were higher and ghrelin level in postnutritional status was lower. The HbA1c levels decreased more intensively in participants with higher GLP-1 levels. TG responders had lower baseline fasting glucose-dependent insulinotropic peptide (GIP) and postprandial ghrelin levels. Conclusion. The evaluation of the glycemic control, lipid profile, and GLP-1, GIP, and ghrelin levels are useable for estimating the expected efficacy of aGLP-1.

show abstract

Metabolic syndrome: Development of D.D.Pletnev’s and G.F.Lang’s ideas

Khalimov

Баранова

Belyaeva

et al. 2022

Pulʹmonologiâ (Mosk.)

View full text Add to dashboard Cite

Metabolic syndrome is a problem of our time due to its high prevalence (from 20 to 50% in the adult population). The aim of the work was to outline the main stages in the study of the totality of hemodynamic and metabolic disorders that was later designated “metabolic syndrome”, in Russia. The article focuses on the development of the ideas of D.D.Pletnev and G.F.Lang from the beginning of the 20th century to the present at the Department of Faculty Therapy in Petrograd Medical Institute for Women, which was later named the First Leningrad Medical Institute and is now named Federal State Budgetary Educational Institution of Higher Education Academician I.P.Pavlov First St. Petersburg State Medical University under the Ministry of Healthcare of Russian Federation. The article discusses current trends in the study of the metabolic syndrome, including data from epidemiological studies on the prevalence of the metabolic syndrome and its individual components in Russia.Results. The paper presents the results of molecular genetic and instrumental methods for examining patients with abdominal obesity, metabolic syndrome, including those with complications such as atrial fibrillation, coronary heart disease, chronic heart failure with preserved left ventricular fraction. The review presents data on the molecular and other features of subcutaneous and visceral (epicardial) adipose tissue.Conclusion. The paper outlines priority areas for studying the metabolic syndrome in the future, which will be important for preventing the development and progression of this pathological condition.

show abstract

Adiponectin levels, lipid proﬁle and glucose metabolism in patients with abdomi-nal obesity

Cited by 8 publications

References 31 publications

Common Carotid Intima–Media Thickness, Levels of Total and High-Molecular Weight Adiponectin in Women With Abdominal Obesity

Common Carotid Intima–Media Thickness, Levels of Total and High-Molecular Weight Adiponectin in Women With Abdominal Obesity

Predictors of Effectiveness of Glucagon-Like Peptide-1 Receptor Agonist Therapy in Patients with Type 2 Diabetes and Obesity

Metabolic syndrome: Development of D.D.Pletnev’s and G.F.Lang’s ideas

Contact Info

Product

Resources

About