Adiponectin-leptin ratio: A useful estimate of insulin resistance in patients with Type 2 diabetes

Zaletel, Jelka; Barlovič, Draženka Pongrac; Preželj, Janez

doi:10.1007/bf03346639

Cited by 82 publications

(74 citation statements)

References 29 publications

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“…Adiponectin/leptin ratio may provide a reliable measure of insulin sensitivity [47]. A high carbohydrate diet promotes glucose intolerance and insulin secretion as well as reduces insulin sensitivity, therefore, increases leptin, an insulinresistance surrogate, and reduces adiponectin, an insulin sensitivity surrogate [46,48,49].…”

Section: Discussionmentioning

confidence: 99%

Exploration of micro- and macronutrient consumption and leverage of interaction with adipokines among Jordanian adults

Tayyem¹,

Hijjawi²,

Bawadi³

et al. 2017

clinical-practice

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Methods and Results:A convenient sample of 167 adults was obtained from students and employees in major hospital in Jordan. Serum concentrations of leptin, adiponectin, resistin and interleukine-6 were measured. Nutrients intakes were assessed using a validated quantitative food frequency questionnaire. Higher levels of leptin were associated with the highest consumption of energy from carbohydrate, insoluble, and soluble fiber (P=0.04). Lower levels of leptin were associated with highest consumption of energy from fat (P=0.04), monounsaturated fatty acids (P=0.04) and cholesterol (P=0.02). Lower levels of adiponectin were found among individuals with the highest consumption of carbohydrates (p=0.02) insoluble fibers (P=0.01); and copper (P=0.03). Higher levels of adiponectin were associated with higher consumption of cholesterol (P=0.03). Leptin/adiponectin ratio was positively associated with the intakes of carbohydrates (P=0.04), soluble-(P=0.01) and insoluble fibers (P=0.01) and copper (P=0.03), whereas the ratio was negatively associated with cholesterol (P=0.04), butyric acid (P=0.03) and omega-3 fatty acids (P=0.03). Levels of resistin were only associated with total fiber intake (P=0.04) and levels of interleukine-6 were only associated with cholesterol intake (P=0.01). Conclusion:Our findings suggest that intakes of carbohydrates, fat, cholesterol and fibers are the major dietary factors that may be associated with levels of leptin and adiponectin. Levels of resistin and interleukine-6 may be less associated with diet composition.

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Section: Discussionmentioning

confidence: 99%

Exploration of micro- and macronutrient consumption and leverage of interaction with adipokines among Jordanian adults

Tayyem¹,

Hijjawi²,

Bawadi³

et al. 2017

clinical-practice

View full text Add to dashboard Cite

show abstract

“…Subsequently, many investigators have reported that the adiponectin/leptin ratio (or leptin/adiponectin ratio) is a relevant and reliable marker of insulin resistance in comparison with other parameters [20]. However, the effect of adipokines on metabolic syndrome and insulin resistance seems to stem from the influence of a combination of adipokines, rather than from the effect of a single adipokine [22].…”

Section: Definition Of Metabolic Syndromementioning

confidence: 99%

“…tin are associated with obesity, and are involved in the process of insulin resistance [7,9,20]. Leptin is an adipose-specific hormone contributing to body weight and energy regulation, and it modulates insulin sensitivity and glucose disposal [11,13,22,46,47].…”

Section: Conflicts Of Interestmentioning

confidence: 99%

“…Leptin is an adipose-specific hormone contributing to body weight and energy regulation, and it modulates insulin sensitivity and glucose disposal [11,13,22,46,47]. Leptin production is influenced by nutritional status, stress, body mass, and the activation of the immune system [20,47,48]. Adiponectin enhances the action of insulin and decreases serum glucose levels [16][17][18][19].…”

Section: Conflicts Of Interestmentioning

confidence: 99%

“…High levels of circulating plasma leptin are associated with many features of metabolic syndrome, such as abdominal obesity, insulin resistance, and high blood pressure. In comparison, increased adiponectin levels cause a reduction in abdominal fat levels, and are associated with insulin sensitivity [14][15][16][17][18][19][20]. Adiponectin is an adipocyte-specific secretory protein, which possesses antidiabetic and antiatherosclerotic properties.…”

mentioning

confidence: 99%

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Association of the leptin to high-molecular-weight adiponectin ratio with metabolic syndrome

et al. 2011

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Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent-resistant membranes

et al. 2012

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Sphingolipids are important structural components of cell membranes and act as critical regulators of cell function by modulating intracellular signaling pathways. Specific sphingolipids, such as ceramide, glucosylceramide, and ganglioside GM3, have been implicated in various aspects of insulin resistance, because they have been shown to modify several steps in the insulin signaling pathway, such as phosphorylation of either protein kinase B (Akt) or of the insulin receptor. We now explore the role of the ceramide acyl chain length in insulin signaling by using a ceramide synthase 2 (CerS2) null mouse, which is unable to synthesize very long acyl chain (C22-C24) ceramides. CerS2 null mice exhibited glucose intolerance despite normal insulin secretion from the pancreas. Both insulin receptor and Akt phosphorylation were abrogated in liver, but not in adipose tissue or in skeletal muscle. The lack of insulin receptor phosphorylation in liver correlated with its inability to translocate into detergent-resistant membranes (DRMs). Moreover, DRMs in CerS2 null mice displayed properties significantly different from those in wild-type mice, suggesting that the altered sphingolipid acyl chain length directly affects insulin receptor translocation and subsequent signaling. Conclusion: We conclude that the sphingolipid acyl chain composition of liver regulates insulin signaling by modifying insulin receptor translocation into membrane microdomains. (HEPATOLOGY 2013;57:525-532)

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Adiponectin-leptin ratio: A useful estimate of insulin resistance in patients with Type 2 diabetes

Cited by 82 publications

References 29 publications

Exploration of micro- and macronutrient consumption and leverage of interaction with adipokines among Jordanian adults

Exploration of micro- and macronutrient consumption and leverage of interaction with adipokines among Jordanian adults

Association of the leptin to high-molecular-weight adiponectin ratio with metabolic syndrome

Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent-resistant membranes

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