Adiponectin, leptin, and lipid profile in type 1 diabetic children and adolescents

El-Maksoud, Awatif M. Abd; Hefnawy, Mohammed H. El; Abdel-Ghaffar, Abdel-Rahman B.; Eskander, Emad F.; Ahmed, Hanaa H.; Seoudi, Dina M.; Yahya, Shaymaa M. M.; Kamal, Ibrahim H.

doi:10.1016/j.jacl.2009.07.002

Cited by 2 publications

(3 citation statements)

References 20 publications

(19 reference statements)

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“…Our findings were consistent with a study done by Snell-Bergeon et al, [17] and Abd El- Maksoud et al, [13], who showed that the leptin levels were lowest among patients with higher HbA1c.…”

Section: Discussionsupporting

confidence: 94%

“…It was consistent with the findings of Kirel et al, [12], Abd EL- Maksoud et al, [13] and Kratzsch et al, [14], who stated that decompensation of metabolism in children with newly diagnosed type 1 diabetes is associated with changes in the leptin axis, with elevated soluble leptin receptors and reduced leptin levels.…”

Section: Discussionsupporting

confidence: 92%

“…In the present study, we reported that there was a statistically significant positive correlation between the mean serum leptin levels and BMI in the diabetic, overweight group and the non-diabetic, overweight group and this was by Al Maskari et al, [18] and Abd EL-Maksoud et al, [13]. Nishimura et al, [19] also revealed that serum leptin levels in school children aged from 9-13 years were positively correlated with the body mass index, irrespective of age or gender.…”

Section: Discussionsupporting

confidence: 67%

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Leptin and Lipid Profile in Overweight Patient with Type 1 Diabetes

Dayem

Kader

Ibrahim

et al. 2017

Open Access Maced J Med Sci

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AIM:To evaluate leptin and lipid profile in overweight patients with type 1 diabetes.PATIENTS AND METHODS:The study included 50 overweight patients with type 1 diabetes and 50 age and sex matched healthy controls. Blood samples were taken for evaluation of glycosylated haemoglobin, lipid profile and leptin. Also, urine samples were taken for evaluation of albumin/creatinine ratio.RESULTS:Leptin level was significantly lower in overweight with type 1 diabetes and showed a significant positive correlation with hip circumference and body mass index and negative correlation with glycosylated haemoglobin (HbA1c). Leptin level was significantly lower in overweight diabetic patients with HbA1c > 7.5 %. The best cut-off point between overweight diabetic group and control group regarding leptin levels was found at 16.9 (ng/ml) with a sensitivity of 68% and specificity of 56%, area under the curve 0.623.CONCLUSION:Leptin levels were found to be low in overweight patients with type 1 diabetes and showed correlation with the body mass index and hip circumference. LDL was significantly higher while HDL was significantly lower in the diabetic, overweight group indicating increased risk of cardiovascular disease. Leptin level in overweight diabetic patients might be related to the metabolic control.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 67%

See 1 more Smart Citation

Leptin and Lipid Profile in Overweight Patient with Type 1 Diabetes

Dayem

Kader

Ibrahim

et al. 2017

Open Access Maced J Med Sci

View full text Add to dashboard Cite

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Levels of adiponectin and leptin at onset of type 1 diabetes have changed over time in children and adolescents

Safai

Eising²,

Hougaard

et al. 2014

Acta Diabetol

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Adiponectin and leptin are proteins secreted by the adipose tissue and have an influence on insulin sensitivity and on inflammatory markers. Altered levels could play a part in the pathogenesis of type 1 diabetes mellitus. We determined adiponectin and leptin levels over a nine-year period in children with type 1 diabetes mellitus (T1D) in relation to the increasing incidence of T1D, and studied the impact of patient status, age, gender and body mass index (BMI). Data were derived from a population-based registry of diabetic children (DanDiabKids) from 1997 to 2005. Children with newly diagnosed T1D (n = 482) were included, and healthy siblings (n = 479) were chosen as a control group. Leptin levels were significantly higher in recent years (in both patients and siblings), whereas for adiponectin, the levels were lower in recent years in the patient group. Leptin levels were lower in children with T1D (RR 0.74, p = 0.003) and in males (RR 0.52, p < 0.001) and increasing with age in both groups. For adiponectin, there was a negative association between level and age in patients. Both adipokines showed a significant correlation with BMI and lower levels in children with blood samples taken within the first 2 days after initiation of insulin treatment. There has been a change in leptin and adiponectin levels in children with or without T1D from 1997 to 2005. This is not explained by changes in BMI and may reflect changes in other factors like diet or physical activity.

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Adiponectin, leptin, and lipid profile in type 1 diabetic children and adolescents

Cited by 2 publications

References 20 publications

Leptin and Lipid Profile in Overweight Patient with Type 1 Diabetes

Leptin and Lipid Profile in Overweight Patient with Type 1 Diabetes

Levels of adiponectin and leptin at onset of type 1 diabetes have changed over time in children and adolescents

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